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Annotation rule MF_00419 |
Accession | MF_00419 |
Dates | 25-JUN-2001 (Created) 23-MAR-2020 (Last updated, Version 44) |
Name | PurL_1 |
Scope | Bacteria |
Templates | P15254 (PUR4_ECOLI); P74881 (PUR4_SALTY): [Recover all] |
Triggered by |
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Protein name |
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Gene name |
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Function | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. |
Catalytic activity | RHEA:17129: ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate
EC 6.3.5.3 |
Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. |
Subunit | Monomer. |
Subcellular location | Cytoplasm. |
Similarity | In the N-terminal section; belongs to the FGAMS family. |
Pfam | PF00586; AIRS; 1; |
PROSITE | PS51273; GATASE_TYPE_1; 1; trigger=PRU00605; |
TIGRFAMs | TIGR01735; FGAM_synt; 1; |
From: PUR4_SALTY (P74881) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND (Optional) | 307 | 318 | ATP | G-A-[SA]-T-G-[SAVI]-G-G-E-I-R-D | ||||||||
NP_BIND (Optional) | 386 | 388 | ATP | T-G-Y | ||||||||
ACT_SITE | 1135 | 1135 | Nucleophile | C | ||||||||
ACT_SITE | 1260 | 1260 | H | |||||||||
ACT_SITE | 1262 | 1262 | E | |||||||||
METAL | 679 | 679 | Magnesium | D | ||||||||
METAL | 718 | 718 | Magnesium | E | ||||||||
METAL | 722 | 722 | Magnesium | N | ||||||||
METAL | 884 | 884 | Magnesium | D | ||||||||
BINDING | 678 | 678 | ATP; via carbonyl oxygen | A | ||||||||
BINDING | 886 | 886 | ATP | S |
Size range | 1293-1369 amino acids |
Related rules | MF_00420 (PURL); MF_00421 (PURQ) |
Fusion | None |
Comments | FGAM synthase can be composed of a single polypeptide (large PurL, MF_00419), or it can be composed of three separate proteins: PurL (small PurL, MF_00420), PurQ (MF_00421) and PurS (MF_01926). |