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HAMAP rule MF_00423

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General rule information [?]

Accession MF_00423
Dates 8-AUG-2001 (Created)
27-JUL-2023 (Last updated, Version 31)
Name SelA
Scope(s) Bacteria
Template(s) P0A821 (SELA_ECOLI); P56372 (SELA_DESBA); O33277 (SELA_MOOTH); [ Recover all ]
Triggered by HAMAP; MF_00423 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SELA
Protein name RecName: Full=L-seryl-tRNA(Sec) selenium transferase;
AltName: Full=Selenocysteine synthase;
                 Short=Sec synthase;
AltName: Full=Selenocysteinyl-tRNA(Sec) synthase;
Gene name Name=selA;

Comments [?]

FUNCTIONConverts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
CATALYTIC ACTIVITY Reaction=H(+) + L-seryl-tRNA(Sec) + selenophosphate = L- selenocysteinyl-tRNA(Sec) + phosphate; Xref=Rhea:RHEA:22728, Rhea:RHEA-COMP:9742, Rhea:RHEA-COMP:9743, ChEBI:CHEBI:15378, ChEBI:CHEBI:16144, ChEBI:CHEBI:43474, ChEBI:CHEBI:78533, ChEBI:CHEBI:78573; EC=;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAYAminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.
case <OC:Enterobacterales>
SUBUNITHomodecamer; pentamer of dimers. Binds only one seryl- tRNA(Sec) per dimer.
end case
SIMILARITYBelongs to the SelA family.

Keywords [?]

Gene Ontology [?]

GO:0004125; Molecular function:L-seryl-tRNA(Sec) selenium transferase activity
GO:0001514; Biological process:selenocysteine incorporation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF03841; SelA; 1;
NCBIfam TIGR00474; SelA; 1;

Features [?]

From: SELA_ECOLI (P0A821)
Key From To Description Tag Condition FTGroup
MOD_RES 295 295 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 386-475 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments A divergent RHILO gene exists (mlr3804)

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