HAMAP rule MF_00423
General rule information
[?]
Accession | MF_00423 |
Dates | 8-AUG-2001 (Created)
27-JUL-2023 (Last updated, Version 31) |
Name | SelA |
Scope(s) |
Bacteria |
Template(s) | P0A821 (SELA_ECOLI); P56372 (SELA_DESBA); O33277 (SELA_MOOTH); [ Recover all ] |
Triggered by |
HAMAP; MF_00423 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | SELA |
Protein name | RecName: Full=L-seryl-tRNA(Sec) selenium transferase; EC=2.9.1.1; AltName: Full=Selenocysteine synthase; Short=Sec synthase; AltName: Full=Selenocysteinyl-tRNA(Sec) synthase; |
Gene name | Name=selA; |
Comments
[?]
FUNCTION | Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. |
CATALYTIC ACTIVITY | Reaction=H(+) + L-seryl-tRNA(Sec) + selenophosphate = L- selenocysteinyl-tRNA(Sec) + phosphate; Xref=Rhea:RHEA:22728, Rhea:RHEA-COMP:9742, Rhea:RHEA-COMP:9743, ChEBI:CHEBI:15378, ChEBI:CHEBI:16144, ChEBI:CHEBI:43474, ChEBI:CHEBI:78533, ChEBI:CHEBI:78573; EC=2.9.1.1; |
COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
PATHWAY | Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1. |
case <OC:Enterobacterales> | |
SUBUNIT | Homodecamer; pentamer of dimers. Binds only one seryl- tRNA(Sec) per dimer. |
end case | |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the SelA family. |
Keywords
[?]
Gene Ontology
[?]
GO:0004125; Molecular function:L-seryl-tRNA(Sec) selenium transferase activity |
GO:0001514; Biological process:selenocysteine incorporation |
GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
Features
[?]
From: SELA_ECOLI (P0A821) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOD_RES | 295 | 295 | /note="N6-(pyridoxal phosphate)lysine" | K |
Additional information
[?]
Size range | 386-475 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | A divergent RHILO gene exists (mlr3804) |