HAMAP rule MF_00423
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00423 |
| Accession | MF_00423 |
| Dates | 28-FEB-2005 (Created)
03-SEP-2024 (Last updated, Version 24) |
| Name | SelA |
| Scope(s) |
Bacteria |
| Template(s) | P0A821; P56372; O33277; [ Recover all ] |
| Triggered by |
HAMAP; MF_00423 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SELA |
| Protein name | RecName: Full=L-seryl-tRNA(Sec) selenium transferase; EC=2.9.1.1; AltName: Full=Selenocysteine synthase; Short=Sec synthase; AltName: Full=Selenocysteinyl-tRNA(Sec) synthase; |
| Gene name | Name=selA; |
Comments
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| FUNCTION | Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. |
| CATALYTIC ACTIVITY | Reaction=L-seryl-tRNA(Sec) + selenophosphate + H(+) = L- selenocysteinyl-tRNA(Sec) + phosphate; Xref=Rhea:RHEA:22728, Rhea:RHEA-COMP:9742, Rhea:RHEA-COMP:9743, ChEBI:CHEBI:15378, ChEBI:CHEBI:16144, ChEBI:CHEBI:43474, ChEBI:CHEBI:78533, ChEBI:CHEBI:78573; EC=2.9.1.1; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| PATHWAY | Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1. |
| case <OC:Enterobacterales> | |
| SUBUNIT | Homodecamer; pentamer of dimers. Binds only one seryl- tRNA(Sec) per dimer. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the SelA family. |
Keywords
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Gene Ontology
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| GO:0004125; Molecular function:L-seryl-tRNA(Sec) selenium transferase activity |
| GO:0001514; Biological process:selenocysteine incorporation |
| GO:0001717; Biological process:conversion of seryl-tRNAsec to selenocys-tRNAsec |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: SELA_ECOLI (P0A821) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 295 | 295 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 386-475 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | A divergent RHILO gene exists (mlr3804) |