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Annotation rule MF_00423
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General rule information [?]

Accession MF_00423
Dates 8-AUG-2001 (Created)
18-NOV-2019 (Last updated, Version 29)
Name SelA
Templates P0A821 (SELA_ECOLI); P56372 (SELA_DESBA); O33277 (SELA_MOOTH): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=L-seryl-tRNA(Sec) selenium transferase;
AltName: Full=Selenocysteine synthase;
Short=Sec synthase;
AltName: Full=Selenocysteinyl-tRNA(Sec) synthase;
Gene name

Comments [?]

Function Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Catalytic activity RHEA:22728: H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate
Cofactor pyridoxal 5'-phosphate
Pathway Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.
case <OC:Enterobacterales>
Subunit Homodecamer; pentamer of dimers. Binds only one seryl-tRNA(Sec) per dimer.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the SelA family.

Keywords [?]

Gene Ontology [?]

GO:0004125; Molecular function: L-seryl-tRNASec selenium transferase activity.
GO:0001514; Biological process: selenocysteine incorporation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF03841; SelA; 1;
TIGRFAMs TIGR00474; SelA; 1;

Features [?]

From: SELA_ECOLI (P0A821)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     295     295       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 386-475 amino acids
Related rules None
Fusion None
Comments A divergent RHILO gene exists (mlr3804)