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HAMAP rule MF_00427

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General rule information [?]

Accession MF_00427
Dates 16-JUL-2001 (Created)
1-JUN-2023 (Last updated, Version 42)
Name NqrC
Scope
Bacteria
Templates Q56582 (NQRC_VIBAL); A5F5Y7 (NQRC_VIBC3): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NQRC
Protein name
RecName: Full=Na(+)-translocating NADH-quinone reductase subunit C;
Short=Na(+)-NQR subunit C;
Short=Na(+)-translocating NQR subunit C;
EC 7.2.1.1;
AltName: Full=NQR complex subunit C;
AltName: Full=NQR-1 subunit C;
Gene name
nqrC

Comments [?]

Function NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
Catalytic activity RHEA:47748: a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)
EC 7.2.1.1
Cofactor FMN
Subunit Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Single-pass membrane protein.
end case
case <FT:1>
Caution The residue potentially involved in the covalent binding of FMN is a Ser instead of a Thr.
end case
Similarity Belongs to the NqrC family.

Keywords [?]

Translocase
NAD
Ubiquinone
Transport
Ion transport
Sodium
Sodium transport
Flavoprotein
FMN
Membrane
Transmembrane
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
case <FT:1> or <FT:2>
Phosphoprotein
end case
Transmembrane helix

Gene Ontology [?]

GO:0010181; Molecular function: FMN binding.
GO:0016655; Molecular function: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor.
GO:0006814; Biological process: sodium ion transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF04205; FMN_bind; 1;
PIRSF PIRSF009437; NQR-1_subunit_C; 1;
NCBIfam TIGR01938; NqrC; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;

Features [?]

From: NQRC_VIBAL (Q56582)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES (Optional)     224     224       FMN phosphoryl serine     S  
MOD_RES (Optional)     224     224       FMN phosphoryl threonine     T  

Additional information [?]

Size range 220-320 amino acids
Related rules None
Fusion None


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