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HAMAP rule MF_00427

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General rule information [?]

Accession MF_00427
Dates 16-JUL-2001 (Created)
1-JUN-2023 (Last updated, Version 42)
Name NqrC
Scope(s) Bacteria
Template(s) Q56582 (NQRC_VIBAL); A5F5Y7 (NQRC_VIBC3); [ Recover all ]
Triggered by HAMAP; MF_00427 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NQRC
Protein name RecName: Full=Na(+)-translocating NADH-quinone reductase subunit C;
                 Short=Na(+)-NQR subunit C;
                 Short=Na(+)-translocating NQR subunit C;
AltName: Full=NQR complex subunit C;
AltName: Full=NQR-1 subunit C;
Gene name Name=nqrC;

Comments [?]

FUNCTIONNQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
CATALYTIC ACTIVITY Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
SUBUNITComposed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Single-pass membrane protein.
end case
case <FT:1>
CAUTIONThe residue potentially involved in the covalent binding of FMN is a Ser instead of a Thr.
end case
SIMILARITYBelongs to the NqrC family.

Keywords [?]

<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>
Ion transport
Sodium transport
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
case <FT:1> or <FT:2>
end case
Transmembrane helix

Gene Ontology [?]

GO:0010181; Molecular function:FMN binding
GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0006814; Biological process:sodium ion transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF04205; FMN_bind; 1;
PIRSF PIRSF009437; NQR-1_subunit_C; 1;
NCBIfam TIGR01938; NqrC; 1;
General Transmembrane; -; 1;

Features [?]

From: NQRC_VIBAL (Q56582)
Key From To Description Tag Condition FTGroup
MOD_RES 224 224 /note="FMN phosphoryl serine" S
MOD_RES 224 224 /note="FMN phosphoryl threonine" T

Additional information [?]

Size range 220-320 amino acids
Related rules None
Fusion Nter: None Cter: None

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