HAMAP rule MF_00427
General rule information
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Accession | MF_00427 |
Dates | 16-JUL-2001 (Created)
3-SEP-2024 (Last updated, Version 43) |
Name | NqrC |
Scope(s) |
Bacteria |
Template(s) | Q56582 (NQRC_VIBAL); A5F5Y7 (NQRC_VIBC3); [ Recover all ] |
Triggered by |
HAMAP; MF_00427 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | NQRC |
Protein name | RecName: Full=Na(+)-translocating NADH-quinone reductase subunit C; Short=Na(+)-NQR subunit C; Short=Na(+)-translocating NQR subunit C; EC=7.2.1.1; AltName: Full=NQR complex subunit C; AltName: Full=NQR-1 subunit C; |
Gene name | Name=nqrC; |
Comments
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FUNCTION | NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. |
CATALYTIC ACTIVITY | Reaction=a ubiquinone + n Na(+)(in) + NADH + H(+) = a ubiquinol + n Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.2.1.1; |
COFACTOR | Name=FMN; Xref=ChEBI:CHEBI:58210; |
SUBUNIT | Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF. |
case not defined <Property:Membrane> or <Property:Membrane=1> | |
SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
else case <Property:Membrane=2> | |
SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
end case | |
case <FT:1> | |
CAUTION | The residue potentially involved in the covalent binding of FMN is a Ser instead of a Thr. |
end case | |
SIMILARITY | Belongs to the NqrC family. |
Keywords
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<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
NAD | |
Ubiquinone | |
Transport | |
Ion transport | |
Sodium | |
Sodium transport | |
Flavoprotein | |
FMN | |
Membrane | |
Transmembrane | |
Cell membrane | |
case defined <Property:Membrane> and <Property:Membrane=2> | |
Cell inner membrane | |
end case | |
case <FT:1> or <FT:2> | |
Phosphoprotein | |
end case | |
Transmembrane helix |
Gene Ontology
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GO:0010181; Molecular function:FMN binding |
GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
GO:0006814; Biological process:sodium ion transport |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF04205; FMN_bind; 1; |
PIRSF | PIRSF009437; NQR-1_subunit_C; 1; |
NCBIfam | TIGR01938; NqrC; 1; |
General | Transmembrane; -; 1; |
Features
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From: NQRC_VIBAL (Q56582) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOD_RES | 224 | 224 | /note="FMN phosphoryl serine" | S | ||||||||
MOD_RES | 224 | 224 | /note="FMN phosphoryl threonine" | T |
Additional information
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Size range | 220-320 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |