HAMAP rule MF_00427

General rule information [?]

Accession	MF_00427
Dates	16-JUL-2001 (Created) 3-SEP-2024 (Last updated, Version 43)
Name	NqrC
Scope(s)	Bacteria
Template(s)	Q56582 (NQRC_VIBAL); A5F5Y7 (NQRC_VIBC3); [ Recover all ]
Triggered by	HAMAP; MF_00427 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	NQRC
Protein name	RecName: Full=Na(+)-translocating NADH-quinone reductase subunit C; Short=Na(+)-NQR subunit C; Short=Na(+)-translocating NQR subunit C; EC=7.2.1.1; AltName: Full=NQR complex subunit C; AltName: Full=NQR-1 subunit C;
Gene name	Name=nqrC;

Comments [?]

FUNCTION	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
CATALYTIC ACTIVITY	Reaction=a ubiquinone + n Na(+)(in) + NADH + H(+) = a ubiquinol + n Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.2.1.1;
COFACTOR	Name=FMN; Xref=ChEBI:CHEBI:58210;
SUBUNIT	Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Single-pass membrane protein.
end case
case <FT:1>
CAUTION	The residue potentially involved in the covalent binding of FMN is a Ser instead of a Thr.
end case
SIMILARITY	Belongs to the NqrC family.

Keywords [?]

<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>
NAD
Ubiquinone
Transport
Ion transport
Sodium
Sodium transport
Flavoprotein
FMN
Membrane
Transmembrane
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
case <FT:1> or <FT:2>
Phosphoprotein
end case
Transmembrane helix

Gene Ontology [?]

GO:0010181; Molecular function:FMN binding

GO:0016655; Molecular function:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

GO:0006814; Biological process:sodium ion transport

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

From: NQRC_VIBAL (Q56582)

Key

From

Description

Tag

Condition

FTGroup

MOD_RES

224

/note="FMN phosphoryl serine"

MOD_RES

224

/note="FMN phosphoryl threonine"

Additional information [?]