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HAMAP rule MF_00430

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General rule information [?]

Accession MF_00430
Dates 19-JUL-2001 (Created)
1-JUN-2023 (Last updated, Version 50)
Name NqrF
Scope(s) Bacteria
Template(s) Q56584 (NQRF_VIBAL); A5F5Y4 (NQRF_VIBC3); [ Recover all ]
Triggered by HAMAP; MF_00430 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NQRF
Protein name RecName: Full=Na(+)-translocating NADH-quinone reductase subunit F;
                 Short=Na(+)-NQR subunit F;
                 Short=Na(+)-translocating NQR subunit F;
                 EC=7.2.1.1;
AltName: Full=NQR complex subunit F;
AltName: Full=NQR-1 subunit F;
Gene name Name=nqrF;

Comments [?]

FUNCTIONNQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
CATALYTIC ACTIVITY Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.2.1.1;
COFACTOR Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 [2Fe-2S] cluster.;
COFACTOR Name=FAD; Xref=ChEBI:CHEBI:57692;
SUBUNITComposed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Single-pass membrane protein.
end case
SIMILARITYBelongs to the NqrF family.

Keywords [?]

<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>
NAD
Ubiquinone
Transport
Ion transport
Sodium
Sodium transport
Flavoprotein
FAD
case <Feature:PS51085>
Metal-binding
Iron-sulfur
Iron
2Fe-2S
end case
Membrane
Transmembrane
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Transmembrane helix

Gene Ontology [?]

GO:0009055; Molecular function:electron transfer activity
GO:0006814; Biological process:sodium ion transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00970; FAD_binding_6; 1;
Pfam PF00111; Fer2; 1;
Pfam PF00175; NAD_binding_1; 1;
PRINTS PR00371; FPNCR; 1;
NCBIfam TIGR01941; NqrF; 1;
PROSITE PS00197; 2FE2S_FER_1; 1;
PROSITE PS51085; 2FE2S_FER_2; 1;
PROSITE PS51384; FAD_FR; 1;
General Transmembrane; -; 1;

Features [?]

From: NQRF_VIBAL (Q56584)
Key From To Description Tag Condition FTGroup
BINDING 69 69 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C
BINDING 75 75 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C
BINDING 78 78 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C
BINDING 110 110 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C

Additional information [?]

Size range 388-452 amino acids
Related rules None
Fusion Nter: None Cter: None



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