HAMAP rule MF_00430
General rule information
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Accession | MF_00430 |
Dates | 19-JUL-2001 (Created)
1-JUN-2023 (Last updated, Version 50) |
Name | NqrF |
Scope(s) |
Bacteria |
Template(s) | Q56584 (NQRF_VIBAL); A5F5Y4 (NQRF_VIBC3); [ Recover all ] |
Triggered by |
HAMAP; MF_00430 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | NQRF |
Protein name | RecName: Full=Na(+)-translocating NADH-quinone reductase subunit F; Short=Na(+)-NQR subunit F; Short=Na(+)-translocating NQR subunit F; EC=7.2.1.1; AltName: Full=NQR complex subunit F; AltName: Full=NQR-1 subunit F; |
Gene name | Name=nqrF; |
Comments
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FUNCTION | NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway. |
CATALYTIC ACTIVITY | Reaction=a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+); Xref=Rhea:RHEA:47748, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:29101, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.2.1.1; |
COFACTOR | Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 [2Fe-2S] cluster.; |
COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
SUBUNIT | Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF. |
case not defined <Property:Membrane> or <Property:Membrane=1> | |
SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
else case <Property:Membrane=2> | |
SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the NqrF family. |
Keywords
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<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
NAD | |
Ubiquinone | |
Transport | |
Ion transport | |
Sodium | |
Sodium transport | |
Flavoprotein | |
FAD | |
case <Feature:PS51085> | |
Metal-binding | |
Iron-sulfur | |
Iron | |
2Fe-2S | |
end case | |
Membrane | |
Transmembrane | |
Cell membrane | |
case defined <Property:Membrane> and <Property:Membrane=2> | |
Cell inner membrane | |
end case | |
Transmembrane helix |
Gene Ontology
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GO:0009055; Molecular function:electron transfer activity |
GO:0006814; Biological process:sodium ion transport |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF00970; FAD_binding_6; 1; |
Pfam | PF00111; Fer2; 1; |
Pfam | PF00175; NAD_binding_1; 1; |
PRINTS | PR00371; FPNCR; 1; |
NCBIfam | TIGR01941; NqrF; 1; |
PROSITE | PS00197; 2FE2S_FER_1; 1; |
PROSITE | PS51085; 2FE2S_FER_2; 1; |
PROSITE | PS51384; FAD_FR; 1; |
General | Transmembrane; -; 1; |
Features
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From: NQRF_VIBAL (Q56584) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 69 | 69 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | ||||||||
BINDING | 75 | 75 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | ||||||||
BINDING | 78 | 78 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | ||||||||
BINDING | 110 | 110 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C |
Additional information
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Size range | 388-452 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |