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Annotation rule MF_00430
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General rule information [?]

Accession MF_00430
Dates 19-JUL-2001 (Created)
11-JAN-2021 (Last updated, Version 46)
Name NqrF
Templates Q56584 (NQRF_VIBAL); A5F5Y4 (NQRF_VIBC3): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Na(+)-translocating NADH-quinone reductase subunit F;
Short=Na(+)-NQR subunit F;
Short=Na(+)-translocating NQR subunit F;
AltName: Full=NQR complex subunit F;
AltName: Full=NQR-1 subunit F;
Gene name

Comments [?]

Function NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.
Catalytic activity RHEA:47748: a ubiquinone + H(+) + n Na(+)(in) + NADH = a ubiquinol + n Na(+)(out) + NAD(+)
Cofactor [2Fe-2S] cluster
Note: Binds 1 [2Fe-2S] cluster.
Subunit Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Single-pass membrane protein.
end case
Similarity Belongs to the NqrF family.

Keywords [?]

case <Feature:PS51085>
end case
case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0009055; Molecular function: electron transfer activity.
GO:0006814; Biological process: sodium ion transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF00970; FAD_binding_6; 1;
PF00111; Fer2; 1;
PF00175; NAD_binding_1; 1;
TIGRFAMs TIGR01941; NqrF; 1;
PROSITE PS00197; 2FE2S_FER_1; 1;
PS51085; 2FE2S_FER_2; 1; trigger=PRU00465;
PS51384; FAD_FR; 1; trigger=PRU00716;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;

Features [?]

From: NQRF_VIBAL (Q56584)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     69     69       Iron-sulfur (2Fe-2S)     C  
METAL     75     75       Iron-sulfur (2Fe-2S)     C  
METAL     78     78       Iron-sulfur (2Fe-2S)     C  
METAL     110     110       Iron-sulfur (2Fe-2S)     C  

Additional information [?]

Size range 388-452 amino acids
Related rules None
Fusion None