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HAMAP rule MF_00440

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General rule information [?]

Accession MF_00440
Dates 22-AUG-2001 (Created)
1-JUN-2023 (Last updated, Version 39)
Name NrdR
Template O69980 (NRDR_STRCO)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Transcriptional repressor NrdR;
Gene name

Comments [?]

Function Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion.
end case
Similarity Belongs to the NrdR family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0045892; Biological process: negative regulation of DNA-templated transcription.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF03477; ATP-cone; 1;
NCBIfam TIGR00244; TIGR00244; 1;
PROSITE PS51161; ATP_CONE; 1; trigger=PRU00492;

Features [?]

From: NRDR_STRCO (O69980)
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     3     34             C-x(2)-C-x(22,24)-C-x(1,2)-C   1

Additional information [?]

Size range 140-225 amino acids
Related rules None
Fusion None
Comments The ATP cone domain can be modelled using the structures for nrdA from E.coli, see AC P00452 and PDB cross-links therein. See also: [1] PubMed=15949864 Rodionov D.A., Gelfand M.S.; "Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling."; Trends Genet. 21:385-389(2005). [2] PubMed=16950922; DOI=10.1128/JB.00903-06; Grinberg I., Shteinberg T., Gorovitz B., Aharonowitz Y., Cohen G., Borovok I.; "The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons."; J. Bacteriol. 188:7635-7644(2006).