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HAMAP rule MF_00440

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General rule information [?]

Accession MF_00440
Dates 22-AUG-2001 (Created)
1-JUN-2023 (Last updated, Version 39)
Name NrdR
Scope(s) Bacteria
Template(s) O69980 (NRDR_STRCO); [ Recover all ]
Triggered by HAMAP; MF_00440 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NRDR
Protein name RecName: Full=Transcriptional repressor NrdR;
Gene name Name=nrdR;

Comments [?]

FUNCTIONNegatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes.
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion.;
end case
SIMILARITYBelongs to the NrdR family.

Keywords [?]

Gene Ontology [?]

GO:0045892; Biological process:negative regulation of DNA-templated transcription
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Pfam PF03477; ATP-cone; 1;
NCBIfam TIGR00244; TIGR00244; 1;

Features [?]

From: NRDR_STRCO (O69980)
Key From To Description Tag Condition FTGroup
ZN_FING 3 34 C-x(2)-C-x(22,24)-C-x(1,2)-C 1

Additional information [?]

Size range 140-225 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The ATP cone domain can be modelled using the structures for nrdA from E.coli, see AC P00452 and PDB cross-links therein. See also: [1] PubMed=15949864 Rodionov D.A., Gelfand M.S.; "Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling."; Trends Genet. 21:385-389(2005). [2] PubMed=16950922; DOI=10.1128/JB.00903-06; Grinberg I., Shteinberg T., Gorovitz B., Aharonowitz Y., Cohen G., Borovok I.; "The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons."; J. Bacteriol. 188:7635-7644(2006).

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