HAMAP rule MF_00440
General rule information
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| Accession | MF_00440 |
| Dates | 22-AUG-2001 (Created)
1-JUN-2023 (Last updated, Version 39) |
| Name | NrdR |
| Scope(s) |
Bacteria Archaea |
| Template(s) | O69980 (NRDR_STRCO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00440 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NRDR |
| Protein name | RecName: Full=Transcriptional repressor NrdR; |
| Gene name | Name=nrdR; |
Comments
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| FUNCTION | Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes. |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion.; |
| end case | |
| SIMILARITY | Belongs to the NrdR family. |
Keywords
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| ATP-binding | |
| DNA-binding | |
| Nucleotide-binding | |
| Repressor | |
| Transcription | |
| Transcription regulation | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| Zinc-finger | |
| end case | |
Gene Ontology
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| GO:0045892; Biological process:negative regulation of DNA-templated transcription | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
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Features
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| From: NRDR_STRCO (O69980) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ZN_FING | 3 | 34 | C-x(2)-C-x(22,24)-C-x(1,2)-C | 1 | ||||||||
Additional information
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| Size range | 140-225 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The ATP cone domain can be modelled using the structures for nrdA from E.coli, see AC P00452 and PDB cross-links therein. See also: [1] PubMed=15949864 Rodionov D.A., Gelfand M.S.; "Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling."; Trends Genet. 21:385-389(2005). [2] PubMed=16950922; DOI=10.1128/JB.00903-06; Grinberg I., Shteinberg T., Gorovitz B., Aharonowitz Y., Cohen G., Borovok I.; "The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons."; J. Bacteriol. 188:7635-7644(2006). |