HAMAP rule MF_00440
General rule information
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| Accession | MF_00440 |
| Dates | 22-AUG-2001 (Created) 1-JUN-2023 (Last updated, Version 39) |
| Name | NrdR |
| Scope | Bacteria
Archaea |
| Template | O69980 (NRDR_STRCO) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. |
case <FTGroup:1>
| Cofactor | Zn(2+) Note: Binds 1 zinc ion. |
end case
| Similarity | Belongs to the NrdR family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0045892; Biological process: negative regulation of DNA-templated transcription.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
Cross-references
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| Pfam | PF03477; ATP-cone; 1; |
| NCBIfam | TIGR00244; TIGR00244; 1; |
| PROSITE | PS51161; ATP_CONE; 1; trigger=PRU00492; |
Features
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| From: NRDR_STRCO (O69980) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ZN_FING | 3 | 34 | C-x(2)-C-x(22,24)-C-x(1,2)-C | 1 | ||||||||
Additional information
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| Size range | 140-225 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | The ATP cone domain can be modelled using the structures for nrdA from E.coli, see AC P00452 and PDB cross-links therein. See also: [1] PubMed=15949864 Rodionov D.A., Gelfand M.S.; "Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling."; Trends Genet. 21:385-389(2005). [2] PubMed=16950922; DOI=10.1128/JB.00903-06; Grinberg I., Shteinberg T., Gorovitz B., Aharonowitz Y., Cohen G., Borovok I.; "The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons."; J. Bacteriol. 188:7635-7644(2006). |