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Annotation rule MF_00440 |
Accession | MF_00440 |
Dates | 22-AUG-2001 (Created) 18-NOV-2019 (Last updated, Version 37) |
Name | NrdR |
Scope | Bacteria
Archaea |
Template | O69980 (NRDR_STRCO) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. |
Cofactor | Zn(2+) Note: Binds 1 zinc ion. |
Similarity | Belongs to the NrdR family. |
Pfam | PF03477; ATP-cone; 1; |
TIGRFAMs | TIGR00244; TIGR00244; 1; |
PROSITE | PS51161; ATP_CONE; 1; trigger=PRU00492; |
From: NRDR_STRCO (O69980) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ZN_FING | 3 | 34 | C-x(2)-C-x(22,24)-C-x(1,2)-C | 1 |
Size range | 140-225 amino acids |
Related rules | None |
Fusion | None |
Comments | The ATP cone domain can be modelled using the structures for nrdA from E.coli, see AC P00452 and PDB cross-links therein. See also: [1] PubMed=15949864 Rodionov D.A., Gelfand M.S.; "Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling."; Trends Genet. 21:385-389(2005). [2] PubMed=16950922; DOI=10.1128/JB.00903-06; Grinberg I., Shteinberg T., Gorovitz B., Aharonowitz Y., Cohen G., Borovok I.; "The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons."; J. Bacteriol. 188:7635-7644(2006). |