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HAMAP rule MF_00451

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General rule information [?]

Accession MF_00451
Dates 18-SEP-2001 (Created)
19-NOV-2022 (Last updated, Version 43)
Name NDP_kinase
Scope
Bacteria
Archaea
Templates P0A763 (NDK_ECOLI); Q59636 (NDK_PSEAE); O85501 (NDK_MYCS2); P61136 (NDK_HALSA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NDK
Protein name
RecName: Full=Nucleoside diphosphate kinase;
Short=NDK;
Short=NDP kinase;
EC 2.7.4.6;
AltName: Full=Nucleoside-2-P kinase;
Gene name
ndk

Comments [?]

Function Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity RHEA:44640: a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
EC 2.7.4.6
RHEA:18113: a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP
EC 2.7.4.6
Cofactor Mg(2+)
case <OC:Bacteria>
Subunit Homotetramer.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the NDK family.

Keywords [?]

Cytoplasm
Magnesium
Metal-binding
Nucleotide metabolism
Nucleotide-binding
Phosphoprotein
Transferase
Kinase
ATP-binding
case <FT:8> or <FT:9>
Phosphoprotein
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004550; Molecular function: nucleoside diphosphate kinase activity.
GO:0006241; Biological process: CTP biosynthetic process.
GO:0006183; Biological process: GTP biosynthetic process.
GO:0006228; Biological process: UTP biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00334; NDK; 1;
PRINTS PR01243; NUCDPKINASE; 1;
PROSITE PS00469; NDP_KINASES; 1;

Features [?]

From: NDK_ECOLI (P0A763)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     117     117       Pros-phosphohistidine intermediate     H  
BINDING     11     11       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     K  
BINDING     59     59       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [FY]  
BINDING     87     87       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     R  
BINDING     93     93       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     T  
BINDING     104     104       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     R  
BINDING     114     114       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     N  
case <OC:Bacillaceae>
From: NDK_BACSU (P31103)
MOD_RES     92     92       Phosphothreonine     T  
MOD_RES     123     123       Phosphoserine     S  
end case

Additional information [?]

Size range 133-174 amino acids
Related rules None
Fusion None
Comments BORBU and PYRAE are divergent; not shown in alignment


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