HAMAP rule MF_00451

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00451
Accession	MF_00451
Dates	28-FEB-2005 (Created) 28-JUN-2024 (Last updated, Version 37)
Name	NDP_kinase
Scope(s)	Bacteria Archaea
Template(s)	P0A763; Q59636; O85501; P61136; [ Recover all ]
Triggered by	HAMAP; MF_00451 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	NDK
Protein name	RecName: Full=Nucleoside diphosphate kinase; Short=NDK; Short=NDP kinase; EC=2.7.4.6; AltName: Full=Nucleoside-2-P kinase;
Gene name	Name=ndk;

Comments [?]

FUNCTION	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
CATALYTIC ACTIVITY	Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'- deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6;
CATALYTIC ACTIVITY	Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'- triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Bacteria>
SUBUNIT	Homotetramer.
end case
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the NDK family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0004550; Molecular function:nucleoside diphosphate kinase activity

GO:0006241; Biological process:CTP biosynthetic process

GO:0006183; Biological process:GTP biosynthetic process

GO:0006228; Biological process:UTP biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: NDK_ECOLI (P0A763)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

117

/note="Pros-phosphohistidine intermediate"

BINDING