HAMAP rule MF_00451
General rule information
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Accession | MF_00451 |
Dates | 18-SEP-2001 (Created) 19-NOV-2022 (Last updated, Version 43) |
Name | NDP_kinase |
Scope | Bacteria
Archaea |
Templates | P0A763 (NDK_ECOLI); Q59636 (NDK_PSEAE); O85501 (NDK_MYCS2); P61136 (NDK_HALSA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. |
Catalytic activity | RHEA:44640: a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
EC 2.7.4.6 |
RHEA:18113: a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP
EC 2.7.4.6 |
|
Cofactor | Mg(2+) |
case <OC:Bacteria>
Subunit | Homotetramer. |
end case
Subcellular location | Cytoplasm. |
Similarity | Belongs to the NDK family. |
Keywords
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Cytoplasm
Magnesium
Metal-binding
Nucleotide metabolism
Nucleotide-binding
Phosphoprotein
Transferase
Kinase
ATP-binding
Magnesium
Metal-binding
Nucleotide metabolism
Nucleotide-binding
Phosphoprotein
Transferase
Kinase
ATP-binding
case <FT:8> or <FT:9>
end case
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0004550; Molecular function: nucleoside diphosphate kinase activity.
GO:0006241; Biological process: CTP biosynthetic process.
GO:0006183; Biological process: GTP biosynthetic process.
GO:0006228; Biological process: UTP biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0004550; Molecular function: nucleoside diphosphate kinase activity.
GO:0006241; Biological process: CTP biosynthetic process.
GO:0006183; Biological process: GTP biosynthetic process.
GO:0006228; Biological process: UTP biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: NDK_ECOLI (P0A763) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 117 | 117 | Pros-phosphohistidine intermediate | H | ||||||||
BINDING | 11 | 11 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | K | ||||||||
BINDING | 59 | 59 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [FY] | ||||||||
BINDING | 87 | 87 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | R | ||||||||
BINDING | 93 | 93 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | T | ||||||||
BINDING | 104 | 104 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | R | ||||||||
BINDING | 114 | 114 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | N |
case <OC:Bacillaceae>
From: NDK_BACSU (P31103) | ||||||||||||
MOD_RES | 92 | 92 | Phosphothreonine | T | ||||||||
MOD_RES | 123 | 123 | Phosphoserine | S |
end case
Additional information
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Size range | 133-174 amino acids |
Related rules | None |
Fusion | None |
Comments | BORBU and PYRAE are divergent; not shown in alignment |