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Annotation rule MF_00453 |
General rule information
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Accession |
MF_00453 |
Dates |
25-SEP-2001 (Created) 18-NOV-2019 (Last updated, Version 30) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Phosphoenolpyruvate carboxykinase (ATP);
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Short=PEP carboxykinase;
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Short=PEPCK;
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EC 4.1.1.49;
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Short=PCK;
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Function |
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. |
Catalytic activity |
RHEA:18617: ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate
EC 4.1.1.49
|
Cofactor |
Mn(2+) Note: Binds 1 Mn(2+) ion per subunit. |
Pathway |
Carbohydrate biosynthesis; gluconeogenesis. |
case <OC:Gammaproteobacteria>
end case
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. |
case <FT:15> or <FT:16>
end case
GO:0005524; Molecular function: ATP binding.
GO:0004612; Molecular function: phosphoenolpyruvate carboxykinase (ATP) activity.
GO:0006094; Biological process: gluconeogenesis.
GO:0005737; Cellular component: cytoplasm.
From: PCKA_ECOLI (P22259) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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248
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256
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ATP
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|
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G-L-S-G-T-G-K-T-T
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NP_BIND
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449
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450
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ATP
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[RK]-[IV]
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METAL
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213
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213
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Manganese
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|
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K
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METAL
|
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232
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232
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Manganese; via tele nitrogen
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|
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H
|
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METAL
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269
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269
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Manganese
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|
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D
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BINDING
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65
|
|
65
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|
Substrate
|
|
|
|
R
|
|
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BINDING
|
|
207
|
|
207
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|
Substrate
|
|
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[YF]
|
|
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BINDING
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|
213
|
|
213
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|
ATP
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|
|
|
K
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|
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BINDING
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|
213
|
|
213
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|
Substrate
|
|
|
|
K
|
|
|
BINDING
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|
232
|
|
232
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ATP
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|
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|
H
|
|
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BINDING
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|
297
|
|
297
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|
ATP
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[ED]
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BINDING
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333
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333
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|
ATP
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|
|
|
R
|
|
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BINDING
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333
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333
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Substrate
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|
|
|
R
|
|
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BINDING
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455
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455
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ATP
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[TS]
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case <OC:Escherichia> or <OC:Shigella>
MOD_RES
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87
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87
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N6-acetyllysine
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K
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MOD_RES
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523
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523
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N6-acetyllysine
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K
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end case
Additional information
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Size range |
493-542 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Probable C-terminally frameshifted DEIRA not taken into alignment and size range. Allosteric regulation by calcium ions is showed only in E.coli, S. typhimurium and T.thermophilus. |