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HAMAP rule MF_00454

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General rule information [?]

Accession MF_00454
Dates 24-SEP-2001 (Created)
1-JUN-2023 (Last updated, Version 61)
Name FluC
Templates Q7VYU0 (FLUC_BORPE); P37002 (FLUC_ECOLI); A0A0H2XLA2 (FLUC_ECOK1); B7LI20 (FLUC_ECO45); Q5FKD2 (FLUC1_LACAC); Q5FKD1 (FLUC2_LACAC): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Fluoride-specific ion channel FluC;
Gene name
fluC, crcB

Comments [?]

Function Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Catalytic activity RHEA:76159: fluoride(in) = fluoride(out)
PhysiologicalDirection=left-to-right (RHEA:76160)
case <FTGroup:1>
Activity regulation Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case
case <FTGroup:1>
end case

Gene Ontology [?]

GO:0062054; Molecular function: fluoride channel activity.
GO:0140114; Biological process: cellular detoxification of fluoride.
GO:1903424; Biological process: fluoride transmembrane transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF02537; CRCB; 1;
NCBIfam TIGR00494; CrcB; 1;

Computed features [?]

General Transmembrane; -; 3-7; trigger=yes;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     77     77       /ligand="Na(+)" /ligand_id="ChEBI:CHEBI:29101" /ligand_note="structural     G   1
BINDING (Optional)     80     80       /ligand="Na(+)" /ligand_id="ChEBI:CHEBI:29101" /ligand_note="structural     [TS]   1

Additional information [?]

Size range 95-290 amino acids
Related rules None
Fusion None
Comments Renamed the Fluc family to avoid confusion with the CLC-type F(-)/H(+) antiporters (see PubMed=23991286).