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HAMAP rule MF_00454

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General rule information [?]

Accession MF_00454
Dates 24-SEP-2001 (Created)
28-NOV-2023 (Last updated, Version 62)
Name FluC
Scope(s) Bacteria
Template(s) Q7VYU0 (FLUC_BORPE); P37002 (FLUC_ECOLI); A0A0H2XLA2 (FLUC_ECOK1); B7LI20 (FLUC_ECO45); Q5FKD2 (FLUC1_LACAC); Q5FKD1 (FLUC2_LACAC); [ Recover all ]
Triggered by HAMAP; MF_00454 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FLUC
Protein name RecName: Full=Fluoride-specific ion channel FluC;
Gene name Name=fluC; Synonyms=crcB;

Comments [?]

FUNCTIONFluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
CATALYTIC ACTIVITY Reaction=fluoride(in) = fluoride(out); Xref=Rhea:RHEA:76159, ChEBI:CHEBI:17051; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76160;
case <FTGroup:1>
ACTIVITY REGULATIONNa(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Ion channel
Ion transport
case <FTGroup:1>
end case
Transmembrane helix

Gene Ontology [?]

GO:0062054; Molecular function:fluoride channel activity
GO:0140114; Biological process:cellular detoxification of fluoride
GO:1903424; Biological process:fluoride transmembrane transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF02537; CRCB; 1;
NCBIfam TIGR00494; CrcB; 1;
General Transmembrane; -; 3-7;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 77 77 /ligand="Na(+)"
G 1
BINDING 80 80 /ligand="Na(+)"
[TS] 1

Additional information [?]

Size range 95-290 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Renamed the Fluc family to avoid confusion with the CLC-type F(-)/H(+) antiporters (see PubMed=23991286).

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