HAMAP rule MF_00454
General rule information
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| Accession | MF_00454 |
| Dates | 24-SEP-2001 (Created)
28-NOV-2023 (Last updated, Version 62) |
| Name | FluC |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q7VYU0 (FLUC_BORPE); P37002 (FLUC_ECOLI); A0A0H2XLA2 (FLUC_ECOK1); B7LI20 (FLUC_ECO45); Q5FKD2 (FLUC1_LACAC); Q5FKD1 (FLUC2_LACAC); [ Recover all ] |
| Triggered by |
HAMAP; MF_00454 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FLUC |
| Protein name | RecName: Full=Fluoride-specific ion channel FluC; |
| Gene name | Name=fluC; Synonyms=crcB; |
Comments
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| FUNCTION | Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. |
| CATALYTIC ACTIVITY | Reaction=fluoride(in) = fluoride(out); Xref=Rhea:RHEA:76159, ChEBI:CHEBI:17051; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76160; |
| case <FTGroup:1> | |
| ACTIVITY REGULATION | Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. |
| end case | |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family. |
Keywords
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| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Ion channel | |
| Ion transport | |
| Membrane | |
| case <FTGroup:1> | |
| Sodium | |
| Metal-binding | |
| end case | |
| Transmembrane | |
| Transmembrane helix | |
| Transport | |
Gene Ontology
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| GO:0062054; Molecular function:fluoride channel activity |
| GO:0140114; Biological process:cellular detoxification of fluoride |
| GO:1903424; Biological process:fluoride transmembrane transport |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF02537; CRCB; 1; |
| NCBIfam | TIGR00494; CrcB; 1; |
| General | Transmembrane; -; 3-7; |
Features
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| From: FLUC_BORPE (Q7VYU0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 77 | 77 | /ligand="Na(+)" /ligand_id="ChEBI:CHEBI:29101" /ligand_note="structural" |
G | 1 | |||||||
| BINDING | 80 | 80 | /ligand="Na(+)" /ligand_id="ChEBI:CHEBI:29101" /ligand_note="structural" |
[TS] | 1 | |||||||
Additional information
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| Size range | 95-290 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Renamed the Fluc family to avoid confusion with the CLC-type F(-)/H(+) antiporters (see PubMed=23991286). |