HAMAP rule MF_00454
General rule information
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Accession | MF_00454 |
Dates | 24-SEP-2001 (Created) 1-JUN-2023 (Last updated, Version 61) |
Name | FluC |
Scope | Bacteria
Archaea |
Templates | Q7VYU0 (FLUC_BORPE); P37002 (FLUC_ECOLI); A0A0H2XLA2 (FLUC_ECOK1); B7LI20 (FLUC_ECO45); Q5FKD2 (FLUC1_LACAC); Q5FKD1 (FLUC2_LACAC): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
Gene name |
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Comments
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Function | Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity. |
Catalytic activity | RHEA:76159: fluoride(in) = fluoride(out)
PhysiologicalDirection=left-to-right (RHEA:76160) |
case <FTGroup:1>
Activity regulation | Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity | Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
case <FTGroup:1>
end case
Gene Ontology
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GO:0062054; Molecular function: fluoride channel activity.
GO:0140114; Biological process: cellular detoxification of fluoride.
GO:1903424; Biological process: fluoride transmembrane transport.
GO:0005886; Cellular component: plasma membrane.
GO:0140114; Biological process: cellular detoxification of fluoride.
GO:1903424; Biological process: fluoride transmembrane transport.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Computed features
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General | Transmembrane; -; 3-7; trigger=yes; |
Features
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From: FLUC_BORPE (Q7VYU0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 77 | 77 | /ligand="Na(+)" /ligand_id="ChEBI:CHEBI:29101" /ligand_note="structural | G | 1 | |||||||
BINDING (Optional) | 80 | 80 | /ligand="Na(+)" /ligand_id="ChEBI:CHEBI:29101" /ligand_note="structural | [TS] | 1 |
Additional information
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Size range | 95-290 amino acids |
Related rules | None |
Fusion | None |
Comments | Renamed the Fluc family to avoid confusion with the CLC-type F(-)/H(+) antiporters (see PubMed=23991286). |