HAMAP rule MF_00469

General rule information [?]

Accession	MF_00469
Dates	24-OCT-2001 (Created) 22-MAY-2020 (Last updated, Version 27)

Name

TrhO

Scope

Bacteria

Template

P24188 (TRHO_ECOLI)

Triggered by

HAMAP; MF_00469 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TRHO

Protein name

RecName:		Full=tRNA uridine(34) hydroxylase;
		EC 1.14.-.-;
AltName:		Full=tRNA hydroxylation protein O;

Gene name

trhO

Comments [?]

case <OC:Escherichia>

Function

Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis. May be part of an alternate pathway, which is able to bypass cmo5U biogenesis in a subset of tRNAs under aerobic conditions.

else

Function

Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

end case

Catalytic activity	RHEA:64224: AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O
Similarity	Belongs to the TrhO family.

Keywords [?]

Oxidoreductase
tRNA processing

Gene Ontology [?]

GO:0006400; Biological process: tRNA modification.
GO:0016705; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.

Cross-references [?]

Pfam	PF00581; Rhodanese; 1;
PROSITE	PS50206; RHODANESE_3; 1; trigger=PRU00173;

Additional information [?]

Size range	239-367 amino acids
Related rules	None
Fusion	None

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