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Annotation rule MF_00469
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General rule information [?]

Accession MF_00469
Dates 24-OCT-2001 (Created)
22-MAY-2020 (Last updated, Version 27)
Name TrhO
Scope
Bacteria
Template P24188 (TRHO_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TRHO
Protein name
RecName: Full=tRNA uridine(34) hydroxylase;
EC 1.14.-.-;
AltName: Full=tRNA hydroxylation protein O;
Gene name
trhO

Comments [?]

case <OC:Escherichia>
Function Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis. May be part of an alternate pathway, which is able to bypass cmo5U biogenesis in a subset of tRNAs under aerobic conditions.
else
Function Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
end case
Catalytic activity RHEA:64224: AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O
Similarity Belongs to the TrhO family.

Keywords [?]


Gene Ontology [?]

GO:0006400; Biological process: tRNA modification.
GO:0016705; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.

Cross-references [?]

Pfam PF00581; Rhodanese; 1;
PROSITE PS50206; RHODANESE_3; 1; trigger=PRU00173;

Additional information [?]

Size range 239-367 amino acids
Related rules None
Fusion None