HAMAP rule MF_00469
General rule information
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Accession | MF_00469 |
Dates | 24-OCT-2001 (Created) 22-MAY-2020 (Last updated, Version 27) |
Name | TrhO |
Scope | Bacteria |
Template | P24188 (TRHO_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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case <OC:Escherichia>
Function | Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5-carboxymethoxyuridine (cmo5U) biosynthesis. May be part of an alternate pathway, which is able to bypass cmo5U biogenesis in a subset of tRNAs under aerobic conditions. |
else
Function | Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. |
end case
Catalytic activity | RHEA:64224: AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O |
Similarity | Belongs to the TrhO family. |
Keywords
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Gene Ontology
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GO:0006400; Biological process: tRNA modification.
GO:0016705; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.
GO:0016705; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.
Cross-references
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Additional information
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Size range | 239-367 amino acids |
Related rules | None |
Fusion | None |