HAMAP rule MF_00469

General rule information [?]

Accession	MF_00469
Dates	24-OCT-2001 (Created) 3-SEP-2024 (Last updated, Version 28)
Name	TrhO
Scope(s)	Bacteria
Template(s)	P24188 (TRHO_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00469 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TRHO
Protein name	RecName: Full=tRNA uridine(34) hydroxylase; EC=1.14.-.-; AltName: Full=tRNA hydroxylation protein O;
Gene name	Name=trhO;

Comments [?]

case <OC:Escherichia>
FUNCTION	Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5- carboxymethoxyuridine (cmo5U) biosynthesis. May be part of an alternate pathway, which is able to bypass cmo5U biogenesis in a subset of tRNAs under aerobic conditions.
else
FUNCTION	Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
end case
CATALYTIC ACTIVITY	Reaction=uridine(34) in tRNA + AH2 + O2 = 5-hydroxyuridine(34) in tRNA + A + H2O; Xref=Rhea:RHEA:64224, Rhea:RHEA-COMP:11727, Rhea:RHEA- COMP:13381, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:65315, ChEBI:CHEBI:136877;
SIMILARITY	Belongs to the TrhO family.

Keywords [?]

Gene Ontology [?]

GO:0006400; Biological process:tRNA modification

GO:0016705; Molecular function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Cross-references [?]

Pfam	PF00581; Rhodanese; 1;
PROSITE	PS50206; RHODANESE_3; 1;

Features [?]

Additional information [?]