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HAMAP rule MF_00469

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General rule information [?]

Accession MF_00469
Dates 24-OCT-2001 (Created)
22-MAY-2020 (Last updated, Version 27)
Name TrhO
Scope(s) Bacteria
Template(s) P24188 (TRHO_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00469 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRHO
Protein name RecName: Full=tRNA uridine(34) hydroxylase;
AltName: Full=tRNA hydroxylation protein O;
Gene name Name=trhO;

Comments [?]

case <OC:Escherichia>
FUNCTIONCatalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs, the first step in 5- carboxymethoxyuridine (cmo5U) biosynthesis. May be part of an alternate pathway, which is able to bypass cmo5U biogenesis in a subset of tRNAs under aerobic conditions.
FUNCTIONCatalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
end case
CATALYTIC ACTIVITY Reaction=AH2 + O2 + uridine(34) in tRNA = 5-hydroxyuridine(34) in tRNA + A + H2O; Xref=Rhea:RHEA:64224, Rhea:RHEA-COMP:11727, Rhea:RHEA- COMP:13381, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:17499, ChEBI:CHEBI:65315, ChEBI:CHEBI:136877;
SIMILARITYBelongs to the TrhO family.

Keywords [?]

Gene Ontology [?]

GO:0006400; Biological process:tRNA modification
GO:0016705; Molecular function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

Cross-references [?]

Pfam PF00581; Rhodanese; 1;

Features [?]

Additional information [?]

Size range 239-367 amino acids
Related rules None
Fusion Nter: None Cter: None

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