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HAMAP rule MF_00475

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General rule information [?]

Accession MF_00475
Dates 25-OCT-2001 (Created)
1-JUN-2023 (Last updated, Version 30)
Name Trp_repressor
Scope(s) Bacteria
Template(s) P0A881 (TRPR_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00475 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRPR
case <OC:Enterobacterales>
Protein name RecName: Full=Trp operon repressor;
else
Protein name RecName: Full=Trp operon repressor homolog;
end case
Gene name Name=trpR;

Comments [?]

case <OC:Enterobacterales>
FUNCTIONThis protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
else
FUNCTIONThis protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription.
end case
SUBUNITHomodimer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the TrpR family.

Keywords [?]


Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0045892; Biological process:negative regulation of DNA-templated transcription
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01371; Trp_repressor; 1;
NCBIfam TIGR01321; TrpR; 1;

Features [?]

From: TRPR_ECOLI (P0A881)
Key From To Description Tag Condition FTGroup
DNA_BIND 68 91

Additional information [?]

Size range 92-125 amino acids
Related rules None
Fusion Nter: None Cter: None



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