HAMAP rule MF_00475
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00475 |
| Accession | MF_00475 |
| Dates | 28-FEB-2005 (Created)
01-JUN-2023 (Last updated, Version 21) |
| Name | Trp_repressor |
| Scope(s) |
Bacteria |
| Template(s) | P0A881; [ Recover all ] |
| Triggered by |
HAMAP; MF_00475 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TRPR |
| case <OC:Enterobacterales> | |
| Protein name | RecName: Full=Trp operon repressor; |
| else | |
| Protein name | RecName: Full=Trp operon repressor homolog; |
| end case | |
| Gene name | Name=trpR; |
Comments
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| case <OC:Enterobacterales> | |
| FUNCTION | This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. |
| else | |
| FUNCTION | This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription. |
| end case | |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the TrpR family. |
Keywords
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Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0045892; Biological process:negative regulation of DNA-templated transcription |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: TRPR_ECOLI (P0A881) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DNA_BIND | 68 | 91 | ||||||||||
Additional information
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| Size range | 92-125 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |