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HAMAP rule MF_00486

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General rule information [?]

Accession MF_00486
Dates 22-NOV-2001 (Created)
1-JUN-2023 (Last updated, Version 33)
Name McH
Scope
Bacteria
Archaea
Templates P94954 (MCH_METKA); O28344 (MCH_ARCFU); O85014 (MCH_METEA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MCH
Protein name
RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
EC 3.5.4.27;
AltName: Full=Methenyl-H4MPT cyclohydrolase;
Gene name
mch

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Function Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
else
Function Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
end case
Catalytic activity RHEA:19053: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin
EC 3.5.4.27
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Pathway One-carbon metabolism; methanogenesis from CO(2); 5,10-methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
end case
case <OC:Archaeoglobales>
Pathway Metabolic intermediate metabolism; lactate oxidation.
end case
case <OC:Bacteria>
Pathway One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (H(4)MPT route): step 3/5.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the MCH family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Methanogenesis
end case
Cytoplasm
One-carbon metabolism
Hydrolase

Gene Ontology [?]

GO:0018759; Molecular function: methenyltetrahydromethanopterin cyclohydrolase activity.
GO:0006730; Biological process: one-carbon metabolic process.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0015948; Biological process: methanogenesis.
end case
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF02289; MCH; 1;
NCBIfam TIGR03120; One_C_mch; 1;

Additional information [?]

Size range 311-337 amino acids
Related rules None
Fusion None


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