HAMAP logo
Due to maintenance work, this service will be unavailable Tuesday 16 between 06:00 and 06:30 - CEST. Apologies for the inconvenience.

HAMAP rule MF_00486

Send feedback

General rule information [?]

Accession MF_00486
Dates 22-NOV-2001 (Created)
12-MAR-2024 (Last updated, Version 34)
Name McH
Scope(s) Bacteria
Archaea
Template(s) P94954 (MCH_METKA); O28344 (MCH_ARCFU); O85014 (MCH_METEA); [ Recover all ]
Triggered by HAMAP; MF_00486 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MCH
Protein name RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
                 EC=3.5.4.27;
AltName: Full=Methenyl-H4MPT cyclohydrolase;
Gene name Name=mch;

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
FUNCTIONCatalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
else
FUNCTIONCatalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT.
end case
CATALYTIC ACTIVITY Reaction=5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = H(+) + N(5)-formyl-5,6,7,8-tetrahydromethanopterin; Xref=Rhea:RHEA:19053, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58018, ChEBI:CHEBI:58337; EC=3.5.4.27;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
PATHWAYOne-carbon metabolism; methanogenesis from CO(2); 5,10- methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 3/3.
end case
case <OC:Archaeoglobales>
PATHWAYMetabolic intermediate metabolism; lactate oxidation.
end case
case <OC:Bacteria>
PATHWAYOne-carbon metabolism; formaldehyde degradation; formate from formaldehyde (H(4)MPT route): step 3/5.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the MCH family.

Keywords [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Methanogenesis
end case
Cytoplasm
One-carbon metabolism
Hydrolase

Gene Ontology [?]

GO:0018759; Molecular function:methenyltetrahydromethanopterin cyclohydrolase activity
GO:0006730; Biological process:one-carbon metabolic process
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0019386; Biological process:methanogenesis, from carbon dioxide
end case
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF02289; MCH; 1;
NCBIfam TIGR03120; One_C_mch; 1;

Features [?]


Additional information [?]

Size range 311-337 amino acids
Related rules None
Fusion Nter: None Cter: None



View rule in raw text format (no links)