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HAMAP rule MF_00487
General rule information
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| Accession | MF_00487 |
| Dates | 22-NOV-2001 (Created)
1-JUN-2023 (Last updated, Version 37) |
| Name | Malate_dehydrog_3 |
| Scope(s) |
Bacteria |
| Template(s) | Q25QU7 (MDH_FLAFR); P80040 (MDH_CHLAA); P80039 (MDH_CHLTE); P61889 (MDH_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00487 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MDH |
| Protein name | RecName: Full=Malate dehydrogenase; EC=1.1.1.37; |
| Gene name | Name=mdh; |
Comments
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| FUNCTION | Catalyzes the reversible oxidation of malate to oxaloacetate. |
| CATALYTIC ACTIVITY | Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate; Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37; |
| SIMILARITY | Belongs to the LDH/MDH superfamily. MDH type 3 family. |
Keywords
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| NAD | |
| Oxidoreductase | |
| Tricarboxylic acid cycle | |
| case <FTTag:phospho> | |
| Phosphoprotein | |
| end case | |
Gene Ontology
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| GO:0030060; Molecular function:L-malate dehydrogenase activity |
| GO:0006099; Biological process:tricarboxylic acid cycle |
Cross-references
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| Pfam | PF02866; Ldh_1_C; 1; |
| Pfam | PF00056; Ldh_1_N; 1; |
| PRINTS | PR00086; LLDHDRGNASE; 1; |
| NCBIfam | TIGR01763; MalateDH_bact; 1; |
| PIRSF | PIRSF000102; Lac_mal_DH; 1; |
Features
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| From: MDH_CHLAA (P80040) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 9 | 14 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
G-x(1,2)-G-x-x-G | ||||||||
| BINDING | 118 | 120 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[VILT]-[GSNAT]-N | ||||||||
| ACT_SITE | 175 | 175 | /note="Proton acceptor" | H | ||||||||
| BINDING | 33 | 33 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
D | ||||||||
| BINDING | 82 | 82 | /ligand="substrate" | R | ||||||||
| BINDING | 88 | 88 | /ligand="substrate" | R | ||||||||
| BINDING | 95 | 95 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
N | ||||||||
| BINDING | 120 | 120 | /ligand="substrate" | N | ||||||||
| BINDING | 151 | 151 | /ligand="substrate" | R | ||||||||
| From: MDH_BACSU (P49814) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Bacillaceae> | ||||||||||||
| MOD_RES | 149 | 149 | /note="Phosphoserine" | phospho | S | |||||||
| end case | ||||||||||||
Additional information
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| Size range | 278-335 amino acids |
| Related rules |
MF_00488 MF_01516 MF_01517 |
| Fusion | Nter: None Cter: None |
| Comments | Also called LDH-like MDH |