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HAMAP rule MF_00487

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General rule information [?]

Accession MF_00487
Dates 22-NOV-2001 (Created)
1-JUN-2023 (Last updated, Version 37)
Name Malate_dehydrog_3
Scope(s) Bacteria
Template(s) Q25QU7 (MDH_FLAFR); P80040 (MDH_CHLAA); P80039 (MDH_CHLTE); P61889 (MDH_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00487 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MDH
Protein name RecName: Full=Malate dehydrogenase;
Gene name Name=mdh;

Comments [?]

FUNCTIONCatalyzes the reversible oxidation of malate to oxaloacetate.
CATALYTIC ACTIVITY Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate; Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
SIMILARITYBelongs to the LDH/MDH superfamily. MDH type 3 family.

Keywords [?]

Gene Ontology [?]

GO:0030060; Molecular function:L-malate dehydrogenase activity
GO:0006099; Biological process:tricarboxylic acid cycle

Cross-references [?]

Pfam PF02866; Ldh_1_C; 1;
Pfam PF00056; Ldh_1_N; 1;
NCBIfam TIGR01763; MalateDH_bact; 1;
PIRSF PIRSF000102; Lac_mal_DH; 1;

Features [?]

From: MDH_CHLAA (P80040)
Key From To Description Tag Condition FTGroup
BINDING 9 14 /ligand="NAD(+)"
BINDING 118 120 /ligand="NAD(+)"
ACT_SITE 175 175 /note="Proton acceptor" H
BINDING 33 33 /ligand="NAD(+)"
BINDING 82 82 /ligand="substrate" R
BINDING 88 88 /ligand="substrate" R
BINDING 95 95 /ligand="NAD(+)"
BINDING 120 120 /ligand="substrate" N
BINDING 151 151 /ligand="substrate" R
From: MDH_BACSU (P49814)
Key From To Description Tag Condition FTGroup
case <OC:Bacillaceae>
MOD_RES 149 149 /note="Phosphoserine" phospho S
end case

Additional information [?]

Size range 278-335 amino acids
Related rules MF_00488
Fusion Nter: None Cter: None
Comments Also called LDH-like MDH

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