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Annotation rule MF_00487
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General rule information [?]

Accession MF_00487
Dates 22-NOV-2001 (Created)
18-NOV-2019 (Last updated, Version 34)
Name Malate_dehydrog_3
Scope
Bacteria
Templates Q25QU7 (MDH_FLAFR); P80040 (MDH_CHLAA); P80039 (MDH_CHLTE); P61889 (MDH_ECOLI): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MDH
Protein name
RecName: Full=Malate dehydrogenase;
EC 1.1.1.37;
Gene name
mdh

Comments [?]

Function Catalyzes the reversible oxidation of malate to oxaloacetate.
Catalytic activity RHEA:21432: (S)-malate + NAD(+) = H(+) + NADH + oxaloacetate
EC 1.1.1.37
Similarity Belongs to the LDH/MDH superfamily. MDH type 3 family.

Keywords [?]

NAD
Oxidoreductase
Tricarboxylic acid cycle
case <FTTag:phospho>
Phosphoprotein
end case

Gene Ontology [?]

GO:0030060; Molecular function: L-malate dehydrogenase activity.
GO:0006099; Biological process: tricarboxylic acid cycle.

Cross-references [?]

Pfam PF02866; Ldh_1_C; 1;
PF00056; Ldh_1_N; 1;
PRINTS PR00086; LLDHDRGNASE; 1;
TIGRFAMs TIGR01763; MalateDH_bact; 1;
PIRSF PIRSF000102; Lac_mal_DH; 1;

Features [?]

From: MDH_CHLAA (P80040)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     9     14       NAD     G-x(1,2)-G-x-x-G  
NP_BIND     118     120       NAD     [VILT]-[GSNAT]-N  
ACT_SITE     175     175       Proton acceptor     H  
BINDING     33     33       NAD     D  
BINDING     82     82       Substrate     R  
BINDING     88     88       Substrate     R  
BINDING     95     95       NAD     N  
BINDING     120     120       Substrate     N  
BINDING     151     151       Substrate     R  
case <OC:Bacillaceae>
From: MDH_BACSU (P49814)
MOD_RES     149     149       Phosphoserine   phospho   S  
end case

Additional information [?]

Size range 278-335 amino acids
Related rules MF_00488 (LDH supersedes the current rule); MF_01516 (MDH); MF_01517 (MDH)
Fusion None
Comments Also called LDH-like MDH


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