HAMAP rule MF_00488
General rule information
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Accession | MF_00488 |
Dates | 23-NOV-2001 (Created) 19-NOV-2022 (Last updated, Version 48) |
Name | Lactate_dehydrog |
Scope | Bacteria |
Templates | P0CW93 (LDH2_BIFLO); P00344 (LDH_GEOSE); P00343 (LDH_LACCA); O32765 (LDH_LACHE); P16115 (LDH_THEMA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the conversion of lactate to pyruvate. |
Catalytic activity | RHEA:23444: (S)-lactate + NAD(+) = H(+) + NADH + pyruvate
EC 1.1.1.27 |
case <FTGroup:1>
Activity regulation | Allosterically activated by fructose 1,6-bisphosphate (FBP). |
end case
Pathway | Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. |
Subunit | Homotetramer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the LDH/MDH superfamily. LDH family. |
Keywords
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case <FTGroup:1>
end case
case <FTTag:Phosphotyrosine>
end case
case <OS:Staphylococcus aureus>
end case
Gene Ontology
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GO:0004459; Molecular function: L-lactate dehydrogenase activity.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF02866; Ldh_1_C; 1; |
PF00056; Ldh_1_N; 1; | |
PRINTS | PR00086; LLDHDRGNASE; 1; |
TIGRFAMs | TIGR01771; L-LDH-NAD; 1; |
TIGR01763; MalateDH_bact; 1; | |
PROSITE | PS00064; L_LDH; 1; |
Features
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From: LDH_GEOSE (P00344) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 83 | 84 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | G-[AVL] | ||||||||
BINDING | 122 | 124 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [AIV]-x-N | ||||||||
BINDING | 124 | 127 | /ligand="substrate | N-x-x-D | ||||||||
BINDING | 152 | 155 | /ligand="substrate | D-x-x-R | ||||||||
ACT_SITE | 179 | 179 | Proton acceptor | H | ||||||||
BINDING | 17 | 17 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | V | ||||||||
BINDING | 38 | 38 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [DNE] | ||||||||
BINDING | 43 | 43 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [RK] | ||||||||
BINDING | 69 | 69 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | Y | ||||||||
BINDING | 86 | 86 | /ligand="substrate | Q | ||||||||
BINDING | 92 | 92 | /ligand="substrate | R | ||||||||
BINDING | 105 | 105 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [ST] | ||||||||
BINDING | 147 | 147 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [ST] | ||||||||
BINDING (Optional) | 157 | 157 | /ligand="beta-D-fructose 1,6-bisphosphate" /ligand_id="ChEBI:CHEBI:32966" /ligand_note="allosteric activator | [RK] | 1 | |||||||
BINDING (Optional) | 172 | 172 | /ligand="beta-D-fructose 1,6-bisphosphate" /ligand_id="ChEBI:CHEBI:32966" /ligand_note="allosteric activator | H | 1 | |||||||
BINDING | 233 | 233 | /ligand="substrate | T | ||||||||
From: LDH_BACSU (P13714) | ||||||||||||
MOD_RES (Optional) | 223 | 223 | Phosphotyrosine | Phosphotyrosine | Y |
Additional information
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Size range | 304-330 amino acids |
Related rules | MF_00487 (MDH); MF_01516 (MDH); MF_01517 (MDH) |
Fusion | None |