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Annotation rule MF_00488 |
General rule information
[?]
Accession |
MF_00488 |
Dates |
23-NOV-2001 (Created) 14-MAY-2022 (Last updated, Version 47) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=L-lactate dehydrogenase;
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Short=L-LDH;
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EC 1.1.1.27;
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Function |
Catalyzes the conversion of lactate to pyruvate. |
Catalytic activity |
RHEA:23444: (S)-lactate + NAD(+) = H(+) + NADH + pyruvate
EC 1.1.1.27
|
case <FTGroup:1>
Activity regulation |
Allosterically activated by fructose 1,6-bisphosphate (FBP). |
end case
Pathway |
Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. |
Subunit |
Homotetramer. |
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the LDH/MDH superfamily. LDH family. |
case <FTGroup:1>
end case
case <FTTag:Phosphotyrosine>
end case
case <OS:Staphylococcus aureus>
end case
GO:0004459; Molecular function: L-lactate dehydrogenase activity.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.
From: LDH_GEOSE (P00344) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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BINDING
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83
|
|
84
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/ligand="NAD(+)" /ligand_id="57540
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|
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G-[AVL]
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BINDING
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122
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|
124
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/ligand="NAD(+)" /ligand_id="57540
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|
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[AIV]-x-N
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BINDING
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124
|
|
127
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/ligand="substrate
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|
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N-x-x-D
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BINDING
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152
|
|
155
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/ligand="substrate
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D-x-x-R
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ACT_SITE
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179
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179
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Proton acceptor
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H
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BINDING
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17
|
|
17
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/ligand="NAD(+)" /ligand_id="57540
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V
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BINDING
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38
|
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38
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/ligand="NAD(+)" /ligand_id="57540
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|
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[DNE]
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BINDING
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43
|
|
43
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/ligand="NAD(+)" /ligand_id="57540
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|
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[RK]
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BINDING
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69
|
|
69
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/ligand="NAD(+)" /ligand_id="57540
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Y
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|
|
BINDING
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86
|
|
86
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/ligand="substrate
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Q
|
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BINDING
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92
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92
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/ligand="substrate
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R
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BINDING
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105
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105
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/ligand="NAD(+)" /ligand_id="57540
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[ST]
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BINDING
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147
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147
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/ligand="NAD(+)" /ligand_id="57540
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[ST]
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BINDING (Optional)
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157
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157
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/ligand="beta-D-fructose 1,6-bisphosphate" /ligand_id="32966" /ligand_note="allosteric activator
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[RK]
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1
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BINDING (Optional)
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172
|
|
172
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/ligand="beta-D-fructose 1,6-bisphosphate" /ligand_id="32966" /ligand_note="allosteric activator
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H
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1
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BINDING
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|
233
|
|
233
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/ligand="substrate
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T
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From: LDH_BACSU (P13714) |
MOD_RES (Optional)
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223
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223
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Phosphotyrosine
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Phosphotyrosine
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Y
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Additional information
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