HAMAP rule MF_00492

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00492
Accession	MF_00492
Dates	28-FEB-2005 (Created) 26-NOV-2025 (Last updated, Version )
Name	Transaldolase_1
Scope(s)	Bacteria
Template(s)	P0A867; P0A870; [ Recover all ]
Triggered by	HAMAP; MF_00492 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TAL
Protein name	RecName: Full=Transaldolase; EC=2.2.1.2;
Gene name	Name=tal;

Comments [?]

FUNCTION	Transaldolase involved in the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedoheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
CATALYTIC ACTIVITY	Reaction=D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate; Xref=Rhea:RHEA:17053, ChEBI:CHEBI:16897, ChEBI:CHEBI:57483, ChEBI:CHEBI:57634, ChEBI:CHEBI:59776; EC=2.2.1.2;
PATHWAY	Carbohydrate degradation; pentose phosphate pathway; D- glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D- ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.
SUBUNIT	Homodimer.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the transaldolase family. Type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004801; Molecular function:transaldolase activity

GO:0006098; Biological process:pentose-phosphate shunt

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

From: TALB_ECOLI (P0A870)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

/note="Proton donor/acceptor"

ACT_SITE

132

/note="Nucleophile; Schiff-base intermediate with substrate"

BINDING