HAMAP rule MF_00492
General rule information
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| Accession | MF_00492 |
| Dates | 28-NOV-2001 (Created) 26-OCT-2021 (Last updated, Version 36) |
| Name | Transaldolase_1 |
| Scope | Bacteria |
| Templates | P0A867 (TALA_ECOLI); P0A870 (TALB_ECOLI): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. |
| Catalytic activity | RHEA:17053: D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate
EC 2.2.1.2 |
| Pathway | Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the transaldolase family. Type 1 subfamily. |
Keywords
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Gene Ontology
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GO:0004801; Molecular function: transaldolase activity.
GO:0006098; Biological process: pentose-phosphate shunt.
GO:0005737; Cellular component: cytoplasm.
GO:0006098; Biological process: pentose-phosphate shunt.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF00923; Transaldolase; 1; |
| PROSITE | PS01054; TRANSALDOLASE_1; 1; |
| PS00958; TRANSALDOLASE_2; 1; | |
| TIGRFAMs | TIGR00874; talAB; 1; |
Features
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| From: TALB_ECOLI (P0A870) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 132 | 132 | Schiff-base intermediate with substrate | K | ||||||||
Additional information
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| Size range | 307-397 amino acids |
| Related rules | MF_00493 (TAL); MF_00494 (TAL); MF_00496 (FSA) |
| Fusion | Nter: None; Cter: <Unknown> |
| Comments | C-terminal domain that contains 2 EF-hands in GLOVI, PROMM, THEVB, PARMW, SYNY3 |