HAMAP rule MF_00495
General rule information
[?]
Accession | MF_00495 |
Dates | 29-NOV-2001 (Created) 26-JAN-2023 (Last updated, Version 39) |
Name | GPH_hydrolase_bact |
Scope | Bacteria |
Templates | P32662 (GPH_ECOLI); P40852 (GPHC_CUPNH); P40853 (GPHP_CUPNH): [Recover all] |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
case not <Property:PHOTOSYN>
Gene name |
|
end case
case <Property:PHOTOSYN>
Gene name |
|
end case
Comments
[?]
case <OC:Pseudomonadota>
Function | Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. |
end case
case not <OC:Pseudomonadota>
Function | Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. |
end case
Catalytic activity | RHEA:14369: 2-phosphoglycolate + H2O = glycolate + phosphate
EC 3.1.3.18 |
Cofactor | Mg(2+) |
case <OC:Enterobacterales>
Cofactor | chloride |
Subunit | Monomer. |
end case
Pathway | Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1. |
Similarity | Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. |
Keywords
[?]
case <Property:PHOTOSYN>
end case
case <OC:Enterobacterales>
end case
Gene Ontology
[?]
GO:0008967; Molecular function: phosphoglycolate phosphatase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0005975; Biological process: carbohydrate metabolic process.
case <Property:PHOTOSYN>
GO:0019253; Biological process: reductive pentose-phosphate cycle.
end case
Cross-references
[?]
Features
[?]
From: GPH_ECOLI (P32662) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 13 | 13 | Nucleophile | D | ||||||||
BINDING | 13 | 13 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
BINDING | 15 | 15 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
BINDING | 192 | 192 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D |
Additional information
[?]
Size range | 212-272 amino acids |
Related rules | None |
Fusion | None |
Comments | Possible overlap with other paralogous genes in many genomes. Divergent gph in SYNE7 not shown in alignment as it could well be a paralog. |