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HAMAP rule MF_00495

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General rule information [?]

Accession MF_00495
Dates 29-NOV-2001 (Created)
26-JAN-2023 (Last updated, Version 39)
Name GPH_hydrolase_bact
Scope(s) Bacteria
Template(s) P32662 (GPH_ECOLI); P40852 (GPHC_CUPNH); P40853 (GPHP_CUPNH); [ Recover all ]
Triggered by HAMAP; MF_00495 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GPH
Protein name RecName: Full=Phosphoglycolate phosphatase;
case not <Property:PHOTOSYN>
Gene name Name=gph;
end case
case <Property:PHOTOSYN>
Gene name Name=cbbZ;
end case

Comments [?]

case <OC:Pseudomonadota>
FUNCTIONSpecifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
end case
case not <OC:Pseudomonadota>
FUNCTIONSpecifically catalyzes the dephosphorylation of 2- phosphoglycolate.
end case
CATALYTIC ACTIVITY Reaction=2-phosphoglycolate + H2O = glycolate + phosphate; Xref=Rhea:RHEA:14369, ChEBI:CHEBI:15377, ChEBI:CHEBI:29805, ChEBI:CHEBI:43474, ChEBI:CHEBI:58033; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Enterobacterales>
COFACTOR Name=chloride; Xref=ChEBI:CHEBI:17996;
end case
PATHWAYOrganic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1.
SIMILARITYBelongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.

Keywords [?]

Carbohydrate metabolism
case <Property:PHOTOSYN>
Calvin cycle
end case
case <OC:Enterobacterales>
end case

Gene Ontology [?]

GO:0008967; Molecular function:phosphoglycolate phosphatase activity
GO:0005975; Biological process:carbohydrate metabolic process
case <Property:PHOTOSYN>
GO:0019253; Biological process:reductive pentose-phosphate cycle
end case

Cross-references [?]

Pfam PF00702; Hydrolase; 1;

Features [?]

From: GPH_ECOLI (P32662)
Key From To Description Tag Condition FTGroup
ACT_SITE 13 13 /note="Nucleophile" D
BINDING 13 13 /ligand="Mg(2+)"
BINDING 15 15 /ligand="Mg(2+)"
BINDING 192 192 /ligand="Mg(2+)"

Additional information [?]

Size range 212-272 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible overlap with other paralogous genes in many genomes. Divergent gph in SYNE7 not shown in alignment as it could well be a paralog.

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