HAMAP logo

HAMAP rule MF_00495

Send feedback

General rule information [?]

Accession MF_00495
Dates 29-NOV-2001 (Created)
26-JAN-2023 (Last updated, Version 39)
Name GPH_hydrolase_bact
Scope
Bacteria
Templates P32662 (GPH_ECOLI); P40852 (GPHC_CUPNH); P40853 (GPHP_CUPNH): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GPH
Protein name
RecName: Full=Phosphoglycolate phosphatase;
Short=PGP;
Short=PGPase;
EC 3.1.3.18;
case not <Property:PHOTOSYN>
Gene name
gph
end case
case <Property:PHOTOSYN>
Gene name
cbbZ
end case

Comments [?]

case <OC:Pseudomonadota>
Function Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
end case
case not <OC:Pseudomonadota>
Function Specifically catalyzes the dephosphorylation of 2-phosphoglycolate.
end case
Catalytic activity RHEA:14369: 2-phosphoglycolate + H2O = glycolate + phosphate
EC 3.1.3.18
Cofactor Mg(2+)
case <OC:Enterobacterales>
Cofactor chloride
Subunit Monomer.
end case
Pathway Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1.
Similarity Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.

Keywords [?]

Carbohydrate metabolism
case <Property:PHOTOSYN>
Calvin cycle
Photosynthesis
end case
Hydrolase
Magnesium
Metal-binding
case <OC:Enterobacterales>
Chloride
end case

Gene Ontology [?]

GO:0008967; Molecular function: phosphoglycolate phosphatase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
case <Property:PHOTOSYN>
GO:0019253; Biological process: reductive pentose-phosphate cycle.
end case

Cross-references [?]

Pfam PF00702; Hydrolase; 1;
PRINTS PR00413; HADHALOGNASE; 1;

Features [?]

From: GPH_ECOLI (P32662)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     13     13       Nucleophile     D  
BINDING     13     13       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D  
BINDING     15     15       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D  
BINDING     192     192       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D  

Additional information [?]

Size range 212-272 amino acids
Related rules None
Fusion None
Comments Possible overlap with other paralogous genes in many genomes. Divergent gph in SYNE7 not shown in alignment as it could well be a paralog.


View rule in raw text format (no links)