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Annotation rule MF_00497
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General rule information [?]

Accession MF_00497
Dates 4-DEC-2001 (Created)
18-NOV-2019 (Last updated, Version 29)
Name G1P_dehydrogenase
Scope
Bacteria; Bacillales
Archaea
Templates P72010 (G1PDH_METTH); Q9YER2 (G1PDH_AERPE); P94527 (G1PDH_BACSU): [Recover all]
case <OC:Bacteria>
end case

case <OC:Archaea>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
G1PDH
Protein name
RecName: Full=Glycerol-1-phosphate dehydrogenase [NAD(P)+];
Short=G1P dehydrogenase;
Short=G1PDH;
EC 1.1.1.261;
AltName: Full=Enantiomeric glycerophosphate synthase;
AltName: Full=sn-glycerol-1-phosphate dehydrogenase;
Gene name
egsA

Comments [?]

case <OC:Archaea>
Function Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
Catalytic activity RHEA:21412: NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH
EC 1.1.1.261
RHEA:21416: NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH
EC 1.1.1.261
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
Pathway Membrane lipid metabolism; glycerophospholipid metabolism.
end case
case <OC:Methanobacteria>
Subunit Homooctamer.
end case
case <OC:Thermoprotei>
Subunit Homodimer.
end case
case <OC:Bacillales>
Function Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species.
Catalytic activity RHEA:21412: NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH
EC 1.1.1.261
RHEA:21416: NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH
EC 1.1.1.261
Cofactor Ni(2+)
Note: Binds 1 nickel ion per subunit.
Subunit Homodimer.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the glycerol-1-phosphate dehydrogenase family.

Keywords [?]

case <OC:Bacillales>
end case
case <OC:Archaea>
end case

Gene Ontology [?]

GO:0050492; Molecular function: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01761; DHQ_synthase; 1;

Features [?]

case <OC:Archaea>
From: G1PDH_METTH (P72010)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     94     98       NAD     G-x-x-x-D  
NP_BIND     116     119       NAD     T-x-x-S  
METAL     168     168       Zinc; catalytic     [DE]  
METAL     248     248       Zinc; catalytic     H  
METAL     264     264       Zinc; catalytic     H  
BINDING     121     121       Substrate     D  
BINDING     125     125       NAD     S  
BINDING     168     168       Substrate     [DE]  
BINDING     252     252       Substrate     H  
end case
case <OC:Bacillales>
From: G1PDH_BACSU (P94527)
NP_BIND     116     120       NAD     G-x-x-x-D  
NP_BIND     138     141       NAD     T-x-x-S  
METAL     190     190       Nickel; catalytic     D  
METAL     270     270       Nickel; catalytic     H  
METAL     290     290       Nickel; catalytic     H  
BINDING     54     54       NAD     D  
BINDING     143     143       Substrate     D  
BINDING     147     147       NAD     S  
BINDING     190     190       Substrate     D  
BINDING     274     274       Substrate     H  
end case

Additional information [?]

case <OC:Bacteria>
Size range 394-404 amino acids
end case
case <OC:Archaea>
Size range 314-360 amino acids
end case
Related rules None
Fusion None