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HAMAP rule MF_00521

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General rule information [?]

Accession MF_00521
Dates 8-JAN-2002 (Created)
25-SEP-2022 (Last updated, Version 29)
Name KDO_kinase
Scope(s) Bacteria
Template(s) O86224 (KDKA_HAEIN); [ Recover all ]
Triggered by HAMAP; MF_00521 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier KDKA
Protein name RecName: Full=3-deoxy-D-manno-octulosonic acid kinase;
                 Short=Kdo kinase;
Gene name Name=kdkA;

Comments [?]

FUNCTIONCatalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
case <OC:Escherichia>
CATALYTIC ACTIVITY Reaction=alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP = 4-O-phospho- alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+); Xref=Rhea:RHEA:28506, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:60364, ChEBI:CHEBI:61589, ChEBI:CHEBI:456216; EC=;
CATALYTIC ACTIVITY Reaction=an alpha-Kdo-(2->6)-lipid IVA + ATP = a 4-O-phospho-alpha-Kdo- (2->6)-lipid IVA + ADP + H(+); Xref=Rhea:RHEA:74271, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:176428, ChEBI:CHEBI:193140, ChEBI:CHEBI:456216; EC=;
end case
PATHWAYBacterial outer membrane biogenesis; LPS core biosynthesis.
SUBCELLULAR LOCATIONCell inner membrane; Peripheral membrane protein; Cytoplasmic side.
SIMILARITYBelongs to the protein kinase superfamily. KdkA/RfaP family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0016773; Molecular function:phosphotransferase activity, alcohol group as acceptor
GO:0009103; Biological process:lipopolysaccharide biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF06293; Kdo; 1;

Features [?]

From: KDKA_HAEIN (O86224)
Key From To Description Tag Condition FTGroup
ACT_SITE 171 171 D

Additional information [?]

Size range 235-259 amino acids
Related rules None
Fusion Nter: None Cter: None

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