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HAMAP rule MF_00521

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General rule information [?]

Accession MF_00521
Dates 8-JAN-2002 (Created)
25-SEP-2022 (Last updated, Version 29)
Name KDO_kinase
Scope
Bacteria
Template O86224 (KDKA_HAEIN)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KDKA
Protein name
RecName: Full=3-deoxy-D-manno-octulosonic acid kinase;
Short=Kdo kinase;
EC 2.7.1.166;
Gene name
kdkA

Comments [?]

Function Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position.
case <OC:Escherichia>
Catalytic activity RHEA:28506: alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP = 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+)
EC 2.7.1.166
else
Catalytic activity RHEA:74271: an alpha-Kdo-(2->6)-lipid IVA + ATP = a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)
EC 2.7.1.166
end case
Pathway Bacterial outer membrane biogenesis; LPS core biosynthesis.
Subcellular location Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.
Similarity Belongs to the protein kinase superfamily. KdkA/RfaP family.

Keywords [?]

ATP-binding
Cell inner membrane
Cell membrane
Kinase
Lipopolysaccharide biosynthesis
Membrane
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0016773; Molecular function: phosphotransferase activity, alcohol group as acceptor.
GO:0009103; Biological process: lipopolysaccharide biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF06293; Kdo; 1;

Features [?]

From: KDKA_HAEIN (O86224)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     171     171             D  

Additional information [?]

Size range 235-259 amino acids
Related rules None
Fusion None


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