HAMAP rule MF_00521
General rule information
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| Accession | MF_00521 |
| Dates | 8-JAN-2002 (Created)
1-MAR-2024 (Last updated, Version 30) |
| Name | KDO_kinase |
| Scope(s) |
Bacteria |
| Template(s) | O86224 (KDKA_HAEIN); [ Recover all ] |
| Triggered by |
HAMAP; MF_00521 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KDKA |
| Protein name | RecName: Full=3-deoxy-D-manno-octulosonic acid kinase; Short=Kdo kinase; EC=2.7.1.166; |
| Gene name | Name=kdkA; |
Comments
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| FUNCTION | Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position. |
| case <OC:Escherichia> | |
| CATALYTIC ACTIVITY | Reaction=alpha-Kdo-(2->6)-lipid IVA (E. coli) + ATP = 4-O-phospho- alpha-Kdo-(2->6)-lipid IVA (E. coli) + ADP + H(+); Xref=Rhea:RHEA:28506, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:60364, ChEBI:CHEBI:61589, ChEBI:CHEBI:456216; EC=2.7.1.166; |
| else | |
| CATALYTIC ACTIVITY | Reaction=an alpha-Kdo-(2->6)-lipid IVA + ATP = a 4-O-phospho-alpha-Kdo- (2->6)-lipid IVA + ADP + H(+); Xref=Rhea:RHEA:74271, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:176428, ChEBI:CHEBI:193140, ChEBI:CHEBI:456216; EC=2.7.1.166; |
| end case | |
| PATHWAY | Bacterial outer membrane biogenesis; LPS core biosynthesis. |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein; Cytoplasmic side. |
| SIMILARITY | Belongs to the protein kinase superfamily. KdkA/RfaP family. |
Keywords
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| ATP-binding |
| Cell inner membrane |
| Cell membrane |
| Kinase |
| Lipopolysaccharide biosynthesis |
| Membrane |
| Nucleotide-binding |
| Transferase |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0016773; Molecular function:phosphotransferase activity, alcohol group as acceptor |
| GO:0009244; Biological process:lipopolysaccharide core region biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF06293; Kdo; 1; |
Features
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| From: KDKA_HAEIN (O86224) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 171 | 171 | D | |||||||||
Additional information
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| Size range | 235-259 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |