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HAMAP rule MF_00540

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General rule information [?]

Accession MF_00540
Dates 27-FEB-2002 (Created)
1-JUN-2023 (Last updated, Version 25)
Name A_deaminase
Scope(s) Bacteria
Template(s) P22333 (ADD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00540 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ADD
Protein name RecName: Full=Adenosine deaminase;
AltName: Full=Adenosine aminohydrolase;
Gene name Name=add;

Comments [?]

FUNCTIONCatalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine.
CATALYTIC ACTIVITY Reaction=adenosine + H(+) + H2O = inosine + NH4(+); Xref=Rhea:RHEA:24408, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16335, ChEBI:CHEBI:17596, ChEBI:CHEBI:28938; EC=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24409;
CATALYTIC ACTIVITY Reaction=2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+); Xref=Rhea:RHEA:28190, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17256, ChEBI:CHEBI:28938, ChEBI:CHEBI:28997; EC=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28191;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
SIMILARITYBelongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004000; Molecular function:adenosine deaminase activity
GO:0009168; Biological process:purine ribonucleoside monophosphate biosynthetic process
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Pfam PF00962; A_deaminase; 1;
NCBIfam TIGR01430; Aden_deam; 1;

Features [?]

From: ADD_ECOLI (P22333)
Key From To Description Tag Condition FTGroup
ACT_SITE 200 200 /note="Proton donor" E
BINDING 12 12 /ligand="Zn(2+)"
H 1
BINDING 14 14 /ligand="Zn(2+)"
H 1
BINDING 197 197 /ligand="Zn(2+)"
H 1
BINDING 278 278 /ligand="Zn(2+)"
D 1
BINDING 14 14 /ligand="substrate" H
BINDING 16 16 /ligand="substrate" D
BINDING 170 170 /ligand="substrate" G
BINDING 279 279 /ligand="substrate" D
SITE 221 221 /note="Important for catalytic activity" H

Additional information [?]

Size range 299-396 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Possible wrong start in STRCO.

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