HAMAP rule MF_00540

General rule information [?]

Accession	MF_00540
Dates	27-FEB-2002 (Created) 19-NOV-2022 (Last updated, Version 24)

Name	A_deaminase

Scope

Bacteria

Template

P22333 (ADD_ECOLI)

Triggered by

HAMAP; MF_00540 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ADD

Protein name

RecName:		Full=Adenosine deaminase;
		EC 3.5.4.4;
AltName:		Full=Adenosine aminohydrolase;

Gene name

add

Comments [?]

Function	Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
Catalytic activity	RHEA:24408: adenosine + H(+) + H2O = inosine + NH4(+) EC 3.5.4.4 PhysiologicalDirection=left-to-right (RHEA:24409)
	RHEA:28190: 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+) EC 3.5.4.4 PhysiologicalDirection=left-to-right (RHEA:28191)

case <FTGroup:1>

Cofactor

Zn(2+)
Note: Binds 1 zinc ion per subunit.

end case

Similarity

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Keywords [?]

Hydrolase
Nucleotide metabolism

case <FTGroup:1>

Metal-binding
Zinc

end case

Gene Ontology [?]

GO:0004000; Molecular function: adenosine deaminase activity.
GO:0009168; Biological process: purine ribonucleoside monophosphate biosynthetic process.

case <FTGroup:1>

GO:0008270; Molecular function: zinc ion binding.

end case

Cross-references [?]

Pfam	PF00962; A_deaminase; 1;
TIGRFAMs	TIGR01430; Aden_deam; 1;
PROSITE	PS00485; A_DEAMINASE; 1;

Features [?]

From: ADD_ECOLI (P22333)

Key From To Description Tag Condition FTGroup

ACT_SITE 200 200 Proton donor E

BINDING 12 12 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic H 1

BINDING 14 14 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic H 1

BINDING 197 197 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic H 1

BINDING 278 278 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic D 1

BINDING (Optional) 14 14 /ligand="substrate H

BINDING (Optional) 16 16 /ligand="substrate D

BINDING (Optional) 170 170 /ligand="substrate G

BINDING (Optional) 279 279 /ligand="substrate D

SITE 221 221 Important for catalytic activity H

Additional information [?]

Size range	299-396 amino acids
Related rules	None
Fusion	None
Comments	Possible wrong start in STRCO.

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