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Annotation rule MF_00540
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General rule information [?]

Accession MF_00540
Dates 27-FEB-2002 (Created)
14-MAY-2022 (Last updated, Version 23)
Name A_deaminase
Scope
Bacteria
Template P22333 (ADD_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ADD
Protein name
RecName: Full=Adenosine deaminase;
EC 3.5.4.4;
AltName: Full=Adenosine aminohydrolase;
Gene name
add

Comments [?]

Function Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
Catalytic activity RHEA:24408: adenosine + H(+) + H2O = inosine + NH4(+)
EC 3.5.4.4
PhysiologicalDirection=left-to-right (RHEA:24409)
RHEA:28190: 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)
EC 3.5.4.4
PhysiologicalDirection=left-to-right (RHEA:28191)
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Similarity Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Keywords [?]

Hydrolase
Nucleotide metabolism
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0004000; Molecular function: adenosine deaminase activity.
GO:0009168; Biological process: purine ribonucleoside monophosphate biosynthetic process.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF00962; A_deaminase; 1;
TIGRFAMs TIGR01430; Aden_deam; 1;
PROSITE PS00485; A_DEAMINASE; 1;

Features [?]

From: ADD_ECOLI (P22333)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     200     200       Proton donor     E  
BINDING     12     12       /ligand="Zn(2+)" /ligand_id="29105" /ligand_note="catalytic     H   1
BINDING     14     14       /ligand="Zn(2+)" /ligand_id="29105" /ligand_note="catalytic     H   1
BINDING     197     197       /ligand="Zn(2+)" /ligand_id="29105" /ligand_note="catalytic     H   1
BINDING     278     278       /ligand="Zn(2+)" /ligand_id="29105" /ligand_note="catalytic     D   1
BINDING (Optional)     14     14       /ligand="substrate     H  
BINDING (Optional)     16     16       /ligand="substrate     D  
BINDING (Optional)     170     170       /ligand="substrate     G  
BINDING (Optional)     279     279       /ligand="substrate     D  
SITE     221     221       Important for catalytic activity     H  

Additional information [?]

Size range 299-396 amino acids
Related rules None
Fusion None
Comments Possible wrong start in STRCO.


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