HAMAP rule MF_00540
General rule information
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Accession | MF_00540 |
Dates | 27-FEB-2002 (Created) 19-NOV-2022 (Last updated, Version 24) |
Name | A_deaminase |
Scope | Bacteria |
Template | P22333 (ADD_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. |
Catalytic activity | RHEA:24408: adenosine + H(+) + H2O = inosine + NH4(+)
EC 3.5.4.4 PhysiologicalDirection=left-to-right (RHEA:24409) |
RHEA:28190: 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)
EC 3.5.4.4 PhysiologicalDirection=left-to-right (RHEA:28191) |
case <FTGroup:1>
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
Similarity | Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0004000; Molecular function: adenosine deaminase activity.
GO:0009168; Biological process: purine ribonucleoside monophosphate biosynthetic process.
GO:0009168; Biological process: purine ribonucleoside monophosphate biosynthetic process.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
Cross-references
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Features
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From: ADD_ECOLI (P22333) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 200 | 200 | Proton donor | E | ||||||||
BINDING | 12 | 12 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 14 | 14 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 197 | 197 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 278 | 278 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | D | 1 | |||||||
BINDING (Optional) | 14 | 14 | /ligand="substrate | H | ||||||||
BINDING (Optional) | 16 | 16 | /ligand="substrate | D | ||||||||
BINDING (Optional) | 170 | 170 | /ligand="substrate | G | ||||||||
BINDING (Optional) | 279 | 279 | /ligand="substrate | D | ||||||||
SITE | 221 | 221 | Important for catalytic activity | H |
Additional information
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Size range | 299-396 amino acids |
Related rules | None |
Fusion | None |
Comments | Possible wrong start in STRCO. |