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Annotation rule MF_00540 |
General rule information
[?]
Accession |
MF_00540 |
Dates |
27-FEB-2002 (Created) 14-MAY-2022 (Last updated, Version 23) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Adenosine deaminase;
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EC 3.5.4.4;
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AltName:
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Full=Adenosine aminohydrolase;
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Function |
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. |
Catalytic activity |
RHEA:24408: adenosine + H(+) + H2O = inosine + NH4(+)
EC 3.5.4.4
PhysiologicalDirection=left-to-right
(RHEA:24409)
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RHEA:28190: 2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)
EC 3.5.4.4
PhysiologicalDirection=left-to-right
(RHEA:28191)
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case <FTGroup:1>
Cofactor |
Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
Similarity |
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. |
case <FTGroup:1>
end case
GO:0004000; Molecular function: adenosine deaminase activity.
GO:0009168; Biological process: purine ribonucleoside monophosphate biosynthetic process.
case <FTGroup:1>
end case
From: ADD_ECOLI (P22333) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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200
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200
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Proton donor
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E
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BINDING
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12
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12
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/ligand="Zn(2+)" /ligand_id="29105" /ligand_note="catalytic
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H
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1
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BINDING
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14
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14
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/ligand="Zn(2+)" /ligand_id="29105" /ligand_note="catalytic
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H
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1
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BINDING
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197
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197
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/ligand="Zn(2+)" /ligand_id="29105" /ligand_note="catalytic
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H
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1
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BINDING
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278
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278
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/ligand="Zn(2+)" /ligand_id="29105" /ligand_note="catalytic
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D
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1
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BINDING (Optional)
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14
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14
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/ligand="substrate
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H
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BINDING (Optional)
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16
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16
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/ligand="substrate
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D
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BINDING (Optional)
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170
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170
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/ligand="substrate
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G
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BINDING (Optional)
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279
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279
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/ligand="substrate
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D
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SITE
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221
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221
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Important for catalytic activity
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H
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Additional information
[?]
Size range |
299-396 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Possible wrong start in STRCO. |