HAMAP rule MF_00540
General rule information
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| Accession | MF_00540 |
| Dates | 27-FEB-2002 (Created)
1-JUN-2023 (Last updated, Version 25) |
| Name | A_deaminase |
| Scope(s) |
Bacteria |
| Template(s) | P22333 (ADD_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00540 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ADD |
| Protein name | RecName: Full=Adenosine deaminase; EC=3.5.4.4; AltName: Full=Adenosine aminohydrolase; |
| Gene name | Name=add; |
Comments
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| FUNCTION | Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. |
| CATALYTIC ACTIVITY | Reaction=adenosine + H(+) + H2O = inosine + NH4(+); Xref=Rhea:RHEA:24408, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16335, ChEBI:CHEBI:17596, ChEBI:CHEBI:28938; EC=3.5.4.4; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24409; |
| CATALYTIC ACTIVITY | Reaction=2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+); Xref=Rhea:RHEA:28190, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17256, ChEBI:CHEBI:28938, ChEBI:CHEBI:28997; EC=3.5.4.4; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28191; |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| SIMILARITY | Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. |
Keywords
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| Hydrolase | |
| Nucleotide metabolism | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0004000; Molecular function:adenosine deaminase activity | |
| GO:0009168; Biological process:purine ribonucleoside monophosphate biosynthetic process | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
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Features
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| From: ADD_ECOLI (P22333) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 200 | 200 | /note="Proton donor" | E | ||||||||
| BINDING | 12 | 12 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 14 | 14 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 197 | 197 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 278 | 278 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
D | 1 | |||||||
| BINDING | 14 | 14 | /ligand="substrate" | H | ||||||||
| BINDING | 16 | 16 | /ligand="substrate" | D | ||||||||
| BINDING | 170 | 170 | /ligand="substrate" | G | ||||||||
| BINDING | 279 | 279 | /ligand="substrate" | D | ||||||||
| SITE | 221 | 221 | /note="Important for catalytic activity" | H | ||||||||
Additional information
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| Size range | 299-396 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Possible wrong start in STRCO. |