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| Annotation rule MF_00549 |
General rule information
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| Accession | MF_00549 |
| Dates | 25-MAR-2002 (Created) 18-NOV-2019 (Last updated, Version 19) |
| Name | Methylglyoxal_synth |
| Scope | Archaea
Bacteria |
| Template | P0A731 (MGSA_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. |
| Catalytic activity | RHEA:17937: dihydroxyacetone phosphate = methylglyoxal + phosphate
EC 4.2.3.3 |
| Similarity | Belongs to the methylglyoxal synthase family. |
Keywords
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Gene Ontology
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GO:0008929; Molecular function: methylglyoxal synthase activity.
GO:0019242; Biological process: methylglyoxal biosynthetic process.
GO:0019242; Biological process: methylglyoxal biosynthetic process.
Cross-references
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| Pfam | PF02142; MGS; 1; |
| TIGRFAMs | TIGR00160; MGSA; 1; |
| PIRSF | PIRSF006614; Methylglyox_syn; 1; |
| PROSITE | PS01335; METHYLGLYOXAL_SYNTH; 1; |
| PS51855; MGS; 1; trigger=PRU01202; |
Features
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| From: MGSA_ECOLI (P0A731) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION (Optional) | 45 | 48 | Substrate binding | T-G-[TAS]-T | ||||||||
| REGION (Optional) | 65 | 66 | Substrate binding | S-G | ||||||||
| ACT_SITE | 71 | 71 | Proton donor/acceptor | D | ||||||||
| BINDING | 19 | 19 | Substrate | H | ||||||||
| BINDING | 23 | 23 | Substrate | K | ||||||||
| BINDING | 98 | 98 | Substrate | H | ||||||||
Additional information
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| Size range | 110-210 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Divergent SYNY3 with an unknown C-terminal domain not shown in alignment and not used in size range |