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HAMAP rule MF_00549

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General rule information [?]

Accession MF_00549
Dates 25-MAR-2002 (Created)
1-JUN-2023 (Last updated, Version 22)
Name Methylglyoxal_synth
Scope(s) Archaea
Template(s) P0A731 (MGSA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00549 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MGSA
Protein name RecName: Full=Methylglyoxal synthase;
Gene name Name=mgsA;

Comments [?]

FUNCTIONCatalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
CATALYTIC ACTIVITY Reaction=dihydroxyacetone phosphate = methylglyoxal + phosphate; Xref=Rhea:RHEA:17937, ChEBI:CHEBI:17158, ChEBI:CHEBI:43474, ChEBI:CHEBI:57642; EC=;
SIMILARITYBelongs to the methylglyoxal synthase family.

Keywords [?]

Gene Ontology [?]

GO:0008929; Molecular function:methylglyoxal synthase activity
GO:0019242; Biological process:methylglyoxal biosynthetic process

Cross-references [?]

Pfam PF02142; MGS; 1;
NCBIfam TIGR00160; MGSA; 1;
PIRSF PIRSF006614; Methylglyox_syn; 1;
PROSITE PS51855; MGS; 1;

Features [?]

From: MGSA_ECOLI (P0A731)
Key From To Description Tag Condition FTGroup
BINDING 45 48 /ligand="substrate" T-G-[TAS]-T
BINDING 65 66 /ligand="substrate" S-G
ACT_SITE 71 71 /note="Proton donor/acceptor" D
BINDING 19 19 /ligand="substrate" H
BINDING 23 23 /ligand="substrate" K
BINDING 98 98 /ligand="substrate" H

Additional information [?]

Size range 110-210 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Divergent SYNY3 with an unknown C-terminal domain not shown in alignment and not used in size range

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