HAMAP rule MF_00549
General rule information
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| Accession | MF_00549 |
| Dates | 25-MAR-2002 (Created)
1-JUN-2023 (Last updated, Version 22) |
| Name | Methylglyoxal_synth |
| Scope(s) |
Archaea Bacteria |
| Template(s) | P0A731 (MGSA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00549 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MGSA |
| Protein name | RecName: Full=Methylglyoxal synthase; Short=MGS; EC=4.2.3.3; |
| Gene name | Name=mgsA; |
Comments
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| FUNCTION | Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. |
| CATALYTIC ACTIVITY | Reaction=dihydroxyacetone phosphate = methylglyoxal + phosphate; Xref=Rhea:RHEA:17937, ChEBI:CHEBI:17158, ChEBI:CHEBI:43474, ChEBI:CHEBI:57642; EC=4.2.3.3; |
| SIMILARITY | Belongs to the methylglyoxal synthase family. |
Keywords
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Gene Ontology
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| GO:0008929; Molecular function:methylglyoxal synthase activity |
| GO:0019242; Biological process:methylglyoxal biosynthetic process |
Cross-references
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| Pfam | PF02142; MGS; 1; |
| NCBIfam | TIGR00160; MGSA; 1; |
| PIRSF | PIRSF006614; Methylglyox_syn; 1; |
| PROSITE | PS01335; METHYLGLYOXAL_SYNTH; 1; |
| PROSITE | PS51855; MGS; 1; |
Features
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| From: MGSA_ECOLI (P0A731) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 45 | 48 | /ligand="substrate" | T-G-[TAS]-T | ||||||||
| BINDING | 65 | 66 | /ligand="substrate" | S-G | ||||||||
| ACT_SITE | 71 | 71 | /note="Proton donor/acceptor" | D | ||||||||
| BINDING | 19 | 19 | /ligand="substrate" | H | ||||||||
| BINDING | 23 | 23 | /ligand="substrate" | K | ||||||||
| BINDING | 98 | 98 | /ligand="substrate" | H | ||||||||
Additional information
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| Size range | 110-210 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Divergent SYNY3 with an unknown C-terminal domain not shown in alignment and not used in size range |