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HAMAP rule MF_00553

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General rule information [?]

Accession MF_00553
Dates 9-MAY-2002 (Created)
1-JUN-2023 (Last updated, Version 31)
Name PAN
Scope(s) Archaea
Template(s) Q58576 (PAN_METJA); O28303 (PAN_ARCFU); D4GUJ7 (PAN1_HALVD); Q5UT56 (PAN2_HALVD); [ Recover all ]
Triggered by HAMAP; MF_00553 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PAN
Protein name RecName: Full=Proteasome-activating nucleotidase;
AltName: Full=Proteasomal ATPase;
AltName: Full=Proteasome regulatory ATPase;
AltName: Full=Proteasome regulatory particle;
Gene name Name=pan;

Comments [?]

FUNCTIONATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
SUBUNITHomohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha- rings of the proteasome core by binding to the intersubunit pockets.
DOMAINConsists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
SIMILARITYBelongs to the AAA ATPase family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0016887; Molecular function:ATP hydrolysis activity
GO:0010498; Biological process:proteasomal protein catabolic process
GO:0043335; Biological process:protein unfolding
GO:0000502; Cellular component:proteasome complex
GO:0005737; Cellular component:cytoplasm
GO:0022623; Cellular component:proteasome-activating nucleotidase complex

Cross-references [?]

PROSITE PS00674; AAA; 1;
Pfam PF00004; AAA; 1;
NCBIfam TIGR01242; 26Sp45; 1;
General Coiled_coil; -; 0-unlimited;

Features [?]

From: PAN_METJA (Q58576)
Key From To Description Tag Condition FTGroup
BINDING 214 219 /ligand="ATP"
REGION 428 430 /note="Docks into pockets in the proteasome alpha-ring to cause gate opening" x-[YF]-x
BINDING 353 353 /ligand="ATP"

Additional information [?]

Size range 392-436 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The protein performing the same function in bacteria (called ARC) is in MF_02112.

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