HAMAP rule MF_00554
General rule information
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Accession | MF_00554 |
Dates | 9-MAY-2002 (Created) 19-NOV-2022 (Last updated, Version 28) |
Name | NEP1 |
Scope | Archaea |
Templates | Q57977 (NEP1_METJA); Q06287 (NEP1_YEAST): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. |
Catalytic activity | RHEA:46696: a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine |
Subunit | Homodimer. |
Similarity | Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. |
Keywords
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Methyltransferase
Ribosome biogenesis
RNA-binding
rRNA-binding
rRNA processing
S-adenosyl-L-methionine
Transferase
Ribosome biogenesis
RNA-binding
rRNA-binding
rRNA processing
S-adenosyl-L-methionine
Transferase
Gene Ontology
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GO:0019843; Molecular function: rRNA binding.
GO:0070037; Molecular function: rRNA (pseudouridine) methyltransferase activity.
GO:0042254; Biological process: ribosome biogenesis.
GO:0006364; Biological process: rRNA processing.
GO:0070037; Molecular function: rRNA (pseudouridine) methyltransferase activity.
GO:0042254; Biological process: ribosome biogenesis.
GO:0006364; Biological process: rRNA processing.
Cross-references
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Pfam | PF03587; EMG1; 1; |
Features
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From: NEP1_METJA (Q57977) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 185 | 190 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | |||||||||
BINDING | 162 | 162 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | G | ||||||||
BINDING | 167 | 167 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | G | ||||||||
SITE | 54 | 54 | Interaction with substrate rRNA | R | ||||||||
SITE | 56 | 56 | Stabilizes Arg-xx | D | ||||||||
SITE | 95 | 95 | Interaction with substrate rRNA | R | ||||||||
SITE | 98 | 98 | Interaction with substrate rRNA | [RK] | ||||||||
SITE | 102 | 102 | Interaction with substrate rRNA | [RN] |
Additional information
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Size range | 205-232 amino acids |
Related rules | None |
Fusion | None |