HAMAP rule MF_00559
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00559 |
| Accession | MF_00559 |
| Dates | 25-MAY-2002 (Created)
3-SEP-2024 (Last updated, Version 31) |
| Name | G3P_dehdrog_arch |
| Scope(s) |
Archaea |
| Template(s) | P10618 (G3P_METFE); P39460 (G3P_SACS2); O59494 (G3P_PYRHO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00559 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | G3P |
| Protein name | RecName: Full=Glyceraldehyde-3-phosphate dehydrogenase; Short=GAPDH; EC=1.2.1.59; AltName: Full=NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase; |
| Gene name | Name=gap; |
Comments
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| CATALYTIC ACTIVITY | Reaction=D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3- phospho-glyceroyl phosphate + NADPH + H(+); Xref=Rhea:RHEA:10296, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57604, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:59776; EC=1.2.1.59; |
| CATALYTIC ACTIVITY | Reaction=D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3- phospho-glyceroyl phosphate + NADH + H(+); Xref=Rhea:RHEA:10300, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57540, ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, ChEBI:CHEBI:59776; EC=1.2.1.59; |
| PATHWAY | Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 1/5. |
| SUBUNIT | Homotetramer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. |
Keywords
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Gene Ontology
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| GO:0004365; Molecular function:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| GO:0006096; Biological process:glycolytic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| PROSITE | PS00071; GAPDH; 1; |
| Pfam | PF02800; Gp_dh_C; 1; |
| Pfam | PF00044; Gp_dh_N; 1; |
| NCBIfam | TIGR01546; GAPDH-II_archae; 1; |
Features
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| From: G3P_PYRHO (O59494) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 12 | 13 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[TS]-[IV] | ||||||||
| BINDING | 140 | 142 | /ligand="D-glyceraldehyde 3-phosphate" /ligand_id="ChEBI:CHEBI:59776" |
S-C-N | ||||||||
| BINDING | 192 | 193 | /ligand="D-glyceraldehyde 3-phosphate" /ligand_id="ChEBI:CHEBI:59776" |
H-[AG] | ||||||||
| ACT_SITE | 141 | 141 | /note="Nucleophile" | C | ||||||||
| BINDING | 111 | 111 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
G | ||||||||
| BINDING | 167 | 167 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
R | ||||||||
| BINDING | 298 | 298 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
Q | ||||||||
Additional information
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| Size range | 334-354 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |