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Annotation rule MF_00559
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General rule information [?]

Accession MF_00559
Dates 25-MAY-2002 (Created)
18-NOV-2019 (Last updated, Version 26)
Name G3P_dehdrog_arch
Scope
Archaea
Templates P10618 (G3P_METFE); P39460 (G3P_SACS2); O59494 (G3P_PYRHO): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
G3P
Protein name
RecName: Full=Glyceraldehyde-3-phosphate dehydrogenase;
Short=GAPDH;
EC 1.2.1.59;
AltName: Full=NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase;
Gene name
gap

Comments [?]

Catalytic activity RHEA:10296: D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH
EC 1.2.1.59
RHEA:10300: D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH
EC 1.2.1.59
Pathway Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.
Subunit Homotetramer.
Subcellular location Cytoplasm.
Similarity Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Keywords [?]


Gene Ontology [?]

GO:0004365; Molecular function: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity.
GO:0006096; Biological process: glycolytic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00071; GAPDH; 1;
Pfam PF02800; Gp_dh_C; 1;
PF00044; Gp_dh_N; 1;
TIGRFAMs TIGR01546; GAPDH-II_archae; 1;

Features [?]

From: G3P_PYRHO (O59494)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     12     13       NAD     [TS]-[IV]  
REGION     140     142       Glyceraldehyde 3-phosphate binding     S-C-N  
REGION     192     193       Glyceraldehyde 3-phosphate binding     H-[AG]  
ACT_SITE     141     141       Nucleophile     C  
BINDING     111     111       NAD; via amide nitrogen     G  
BINDING     167     167       NAD     R  
BINDING     298     298       NAD; via carbonyl oxygen     Q  

Additional information [?]

Size range 334-354 amino acids
Related rules None
Fusion None