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HAMAP rule MF_00562

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General rule information [?]

Accession MF_00562
Dates 31-MAY-2002 (Created)
6-JAN-2022 (Last updated, Version 29)
Name Deacylase_DtdA
Scope(s) Archaea
Template(s) Q9V2R8 (DTDA_PYRAB); [ Recover all ]
Triggered by HAMAP; MF_00562 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DTDA
Protein name RecName: Full=D-aminoacyl-tRNA deacylase;
Gene name Name=dtdA;

Comments [?]

FUNCTIOND-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
CATALYTIC ACTIVITY Reaction=a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+); Xref=Rhea:RHEA:13953, Rhea:RHEA-COMP:10123, Rhea:RHEA-COMP:10124, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59871, ChEBI:CHEBI:78442, ChEBI:CHEBI:79333; EC=;
CATALYTIC ACTIVITY Reaction=glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala); Xref=Rhea:RHEA:53744, Rhea:RHEA-COMP:9657, Rhea:RHEA-COMP:13640, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57305, ChEBI:CHEBI:78442, ChEBI:CHEBI:78522; EC=;
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
SIMILARITYBelongs to the DtdA deacylase family.

Keywords [?]

Gene Ontology [?]

GO:0008270; Molecular function:zinc ion binding
GO:0016788; Molecular function:hydrolase activity, acting on ester bonds
GO:0051499; Molecular function:D-aminoacyl-tRNA deacylase activity
GO:0019478; Biological process:D-amino acid catabolic process

Cross-references [?]

Pfam PF04414; tRNA_deacylase; 1;
PIRSF PIRSF016210; UCP016210; 1;

Features [?]

Additional information [?]

Size range 237-524 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Divergent HALSA not shown in alignment

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