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HAMAP rule MF_00562

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General rule information [?]

Accession MF_00562
Dates 31-MAY-2002 (Created)
6-JAN-2022 (Last updated, Version 29)
Name Deacylase_DtdA
Template Q9V2R8 (DTDA_PYRAB)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=D-aminoacyl-tRNA deacylase;
Gene name

Comments [?]

Function D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
Catalytic activity RHEA:13953: a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)
RHEA:53744: glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)
Cofactor Zn(2+)
Note: Binds 2 Zn(2+) ions per subunit.
Subunit Monomer.
Similarity Belongs to the DtdA deacylase family.

Keywords [?]

Gene Ontology [?]

GO:0008270; Molecular function: zinc ion binding.
GO:0016788; Molecular function: hydrolase activity, acting on ester bonds.
GO:0051499; Molecular function: D-aminoacyl-tRNA deacylase activity.
GO:0019478; Biological process: D-amino acid catabolic process.

Cross-references [?]

Pfam PF04414; tRNA_deacylase; 1;
PIRSF PIRSF016210; UCP016210; 1;

Additional information [?]

Size range 237-524 amino acids
Related rules None
Fusion None
Comments Divergent HALSA not shown in alignment