HAMAP rule MF_00562
General rule information
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| Accession | MF_00562 |
| Dates | 31-MAY-2002 (Created) 6-JAN-2022 (Last updated, Version 29) |
| Name | Deacylase_DtdA |
| Scope | Archaea |
| Template | Q9V2R8 (DTDA_PYRAB) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. |
| Catalytic activity | RHEA:13953: a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)
EC 3.1.1.96 |
| RHEA:53744: glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)
EC 3.1.1.96 |
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| Cofactor | Zn(2+) Note: Binds 2 Zn(2+) ions per subunit. |
| Subunit | Monomer. |
| Similarity | Belongs to the DtdA deacylase family. |
Keywords
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Gene Ontology
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GO:0008270; Molecular function: zinc ion binding.
GO:0016788; Molecular function: hydrolase activity, acting on ester bonds.
GO:0051499; Molecular function: D-aminoacyl-tRNA deacylase activity.
GO:0019478; Biological process: D-amino acid catabolic process.
GO:0016788; Molecular function: hydrolase activity, acting on ester bonds.
GO:0051499; Molecular function: D-aminoacyl-tRNA deacylase activity.
GO:0019478; Biological process: D-amino acid catabolic process.
Cross-references
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| Pfam | PF04414; tRNA_deacylase; 1; |
| PIRSF | PIRSF016210; UCP016210; 1; |
Additional information
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| Size range | 237-524 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Divergent HALSA not shown in alignment |