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Annotation rule MF_00564 |
Accession | MF_00564 |
Dates | 27-JUN-2002 (Created) 18-NOV-2019 (Last updated, Version 22) |
Name | RNase_PH |
Scope | Bacteria |
Templates | P28619 (RNPH_BACSU); P0CG18 (RNPH_ECOBW); P0CG19 (RNPH_ECOLI): [Recover all] |
Triggered by |
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Protein name |
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Gene name |
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Function | Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. |
Catalytic activity | RHEA:10628: phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)
EC 2.7.7.56 |
Subunit | Homohexameric ring arranged as a trimer of dimers. |
Similarity | Belongs to the RNase PH family. |
Pfam | PF01138; RNase_PH; 1; |
PF03725; RNase_PH_C; 1; | |
PROSITE | PS01277; RIBONUCLEASE_PH; 1; |
TIGRFAMs | TIGR01966; RNasePH; 1; |
From: RNPH_PSEAE (P50597) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 125 | 127 | Phosphate (substrate) binding | [GS]-T-R | ||||||||
BINDING | 87 | 87 | Phosphate (substrate) binding | R |