HAMAP rule MF_00564

Accession	MF_00564
Dates	27-JUN-2002 (Created) 1-JUN-2023 (Last updated, Version 29)

Name

RNase_PH

Scope

Bacteria

Templates

P28619 (RNPH_BACSU); P0CG18 (RNPH_ECOBW); P0CG19 (RNPH_ECOLI): [Recover all]

Triggered by

HAMAP; MF_00564 (Get profile general information and statistics)

Identifier

RNPH

Protein name

RecName: Full=Ribonuclease PH; Short=RNase PH; EC 2.7.7.56; AltName: Full=tRNA nucleotidyltransferase;

Gene name

rph

Function	Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
Catalytic activity	RHEA:10628: phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n) EC 2.7.7.56
Subunit	Homohexameric ring arranged as a trimer of dimers.
Similarity	Belongs to the RNase PH family.

Transferase
Nucleotidyltransferase
rRNA processing
tRNA processing
tRNA-binding

GO:0000049; Molecular function: tRNA binding.
GO:0009022; Molecular function: phosphate-dependent exonuclease activity.
GO:0008033; Biological process: tRNA processing.
GO:0000175; Molecular function: 3'-5'-RNA exonuclease activity.
GO:0016075; Biological process: rRNA catabolic process.

Pfam	PF01138; RNase_PH; 1;
	PF03725; RNase_PH_C; 1;
PROSITE	PS01277; RIBONUCLEASE_PH; 1;
NCBIfam	TIGR01966; RNasePH; 1;

From: RNPH_PSEAE (P50597)

Key

From

To

Description

Tag

Condition

FTGroup

BINDING

125

127

/ligand="phosphate" /ligand_id="ChEBI:CHEBI:43474" /ligand_note="substrate

[GS]-T-R

BINDING

87

87

/ligand="phosphate" /ligand_id="ChEBI:CHEBI:43474" /ligand_note="substrate

R

Size range	221-261 amino acids
Related rules	MF_00591 (RRP41); MF_00622 (RRP42)
Fusion	None

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