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Annotation rule MF_00564
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General rule information [?]

Accession MF_00564
Dates 27-JUN-2002 (Created)
18-NOV-2019 (Last updated, Version 22)
Name RNase_PH
Scope
Bacteria
Templates P28619 (RNPH_BACSU); P0CG18 (RNPH_ECOBW); P0CG19 (RNPH_ECOLI): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RNPH
Protein name
RecName: Full=Ribonuclease PH;
Short=RNase PH;
EC 2.7.7.56;
AltName: Full=tRNA nucleotidyltransferase;
Gene name
rph

Comments [?]

Function Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
Catalytic activity RHEA:10628: phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)
EC 2.7.7.56
Subunit Homohexameric ring arranged as a trimer of dimers.
Similarity Belongs to the RNase PH family.

Keywords [?]

Transferase
Nucleotidyltransferase
rRNA processing
tRNA processing
tRNA-binding

Gene Ontology [?]

GO:0000049; Molecular function: tRNA binding.
GO:0009022; Molecular function: tRNA nucleotidyltransferase activity.
GO:0008033; Biological process: tRNA processing.
GO:0000175; Molecular function: 3'-5'-exoribonuclease activity.
GO:0016075; Biological process: rRNA catabolic process.

Cross-references [?]

Pfam PF01138; RNase_PH; 1;
PF03725; RNase_PH_C; 1;
PROSITE PS01277; RIBONUCLEASE_PH; 1;
TIGRFAMs TIGR01966; RNasePH; 1;

Features [?]

From: RNPH_PSEAE (P50597)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     125     127       Phosphate (substrate) binding     [GS]-T-R  
BINDING     87     87       Phosphate (substrate) binding     R  

Additional information [?]

Size range 221-261 amino acids
Related rules MF_00591 (RRP41); MF_00622 (RRP42)
Fusion None


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