HAMAP rule MF_00568
General rule information
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Accession | MF_00568 |
Dates | 2-JUL-2002 (Created)
1-JUN-2023 (Last updated, Version 39) |
Name | NadA_type2 |
Scope(s) |
Bacteria Archaea Plastid |
Template(s) | O57767 (NADA_PYRHO); Q9X1X7 (NADA_THEMA); Q8TZL3 (NADA_PYRFU); [ Recover all ] |
Triggered by |
HAMAP; MF_00568 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | NADA |
Protein name | RecName: Full=Quinolinate synthase; EC=2.5.1.72; |
Gene name | Name=nadA; |
Comments
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FUNCTION | Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. |
CATALYTIC ACTIVITY | Reaction=dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate; Xref=Rhea:RHEA:25888, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29959, ChEBI:CHEBI:43474, ChEBI:CHEBI:57642, ChEBI:CHEBI:77875; EC=2.5.1.72; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25889; |
COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; |
PATHWAY | Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1. |
case not <OG:Chloroplast> | |
SUBCELLULAR LOCATION | Cytoplasm. |
end case | |
case <OG:Chloroplast> | |
SUBCELLULAR LOCATION | Plastid, chloroplast. |
end case | |
SIMILARITY | Belongs to the quinolinate synthase family. Type 2 subfamily. |
Keywords
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4Fe-4S | |
case not <OG:Chloroplast> | |
Cytoplasm | |
end case | |
Iron | |
Iron-sulfur | |
Metal-binding | |
Pyridine nucleotide biosynthesis | |
Transferase |
Gene Ontology
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GO:0008987; Molecular function:quinolinate synthetase A activity | |
GO:0009435; Biological process:NAD biosynthetic process | |
case not <OG:Chloroplast> | |
GO:0005737; Cellular component:cytoplasm | |
end case | |
case <OG:Chloroplast> | |
GO:0009507; Cellular component:chloroplast | |
end case |
Cross-references
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Features
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From: NADA_PYRHO (O57767) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 109 | 111 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
Y-[VIF]-N | ||||||||
BINDING | 196 | 198 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
H-P-E | ||||||||
BINDING | 83 | 83 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
BINDING | 170 | 170 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
BINDING | 256 | 256 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
BINDING | 21 | 21 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
H | ||||||||
BINDING | 38 | 38 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
S | ||||||||
BINDING | 126 | 126 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
S | ||||||||
BINDING | 213 | 213 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
T |
Additional information
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Size range | 298-377 amino acids |
Related rules |
MF_00567 MF_00569 |
Fusion | Nter: None Cter: None |