HAMAP rule MF_00568
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00568 |
| Accession | MF_00568 |
| Dates | 28-FEB-2005 (Created)
12-JUN-2025 (Last updated, Version 34) |
| Name | NadA_type2 |
| Scope(s) |
Bacteria Archaea Plastid |
| Template(s) | O57767; Q9X1X7; Q8TZL3; [ Recover all ] |
| Triggered by |
HAMAP; MF_00568 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NADA |
| Protein name | RecName: Full=Quinolinate synthase; EC=2.5.1.72; |
| Gene name | Name=nadA; |
Comments
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| FUNCTION | Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. |
| CATALYTIC ACTIVITY | Reaction=iminosuccinate + dihydroxyacetone phosphate = quinolinate + phosphate + 2 H2O + H(+); Xref=Rhea:RHEA:25888, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29959, ChEBI:CHEBI:43474, ChEBI:CHEBI:57642, ChEBI:CHEBI:77875; EC=2.5.1.72; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25889; |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; |
| PATHWAY | Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1. |
| case not <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| case <OG:Chloroplast> | |
| SUBCELLULAR LOCATION | Plastid, chloroplast. |
| end case | |
| SIMILARITY | Belongs to the quinolinate synthase family. Type 2 subfamily. |
Keywords
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| 4Fe-4S | |
| case not <OG:Chloroplast> | |
| Cytoplasm | |
| end case | |
| Iron | |
| Iron-sulfur | |
| Metal-binding | |
| Pyridine nucleotide biosynthesis | |
| Transferase | |
Gene Ontology
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| GO:0008987; Molecular function:quinolinate synthetase A activity | |
| GO:0009435; Biological process:NAD+ biosynthetic process | |
| case not <OG:Chloroplast> | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
| case <OG:Chloroplast> | |
| GO:0009507; Cellular component:chloroplast | |
| end case | |
Cross-references
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Features
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| From: NADA_PYRHO (O57767) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 109 | 111 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
Y-[VIF]-N | ||||||||
| BINDING | 196 | 198 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
H-P-E | ||||||||
| BINDING | 83 | 83 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 170 | 170 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 256 | 256 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 21 | 21 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
H | ||||||||
| BINDING | 38 | 38 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
S | ||||||||
| BINDING | 126 | 126 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
S | ||||||||
| BINDING | 213 | 213 | /ligand="iminosuccinate" /ligand_id="ChEBI:CHEBI:77875" |
T | ||||||||
Additional information
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| Size range | 298-377 amino acids |
| Related rules |
MF_00567 MF_00569 |
| Fusion | Nter: None Cter: None |