HAMAP rule MF_00570

General rule information [?]

Accession	MF_00570
Dates	5-JUL-2002 (Created) 1-JUN-2023 (Last updated, Version 33)

Name

NAPRTase

Scope

Bacteria

Archaea

Templates

P18133 (PNCB_ECOLI); P22253 (PNCB_SALTY): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PNCB

Protein name

RecName:		Full=Nicotinate phosphoribosyltransferase;
		Short=NAPRTase;
		EC 6.3.4.21;

Gene name

pncB

Comments [?]

Function	Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
Catalytic activity	RHEA:36163: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate EC 6.3.4.21
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.

case <FTTag:phospho>

Ptm	Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

end case

Similarity

Belongs to the NAPRTase family.

Keywords [?]

case <FTTag:phospho>

end case

Gene Ontology [?]

GO:0004516; Molecular function: nicotinate phosphoribosyltransferase activity.
GO:0009435; Biological process: NAD biosynthetic process.

Cross-references [?]