HAMAP rule MF_00570

General rule information [?]

Accession	MF_00570
Dates	5-JUL-2002 (Created) 3-SEP-2024 (Last updated, Version 34)
Name	NAPRTase
Scope(s)	Bacteria Archaea
Template(s)	P18133 (PNCB_ECOLI); P22253 (PNCB_SALTY); [ Recover all ]
Triggered by	HAMAP; MF_00570 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PNCB
Protein name	RecName: Full=Nicotinate phosphoribosyltransferase; Short=NAPRTase; EC=6.3.4.21;
Gene name	Name=pncB;

Comments [?]

FUNCTION	Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
CATALYTIC ACTIVITY	Reaction=nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate; Xref=Rhea:RHEA:36163, ChEBI:CHEBI:15377, ChEBI:CHEBI:30616, ChEBI:CHEBI:32544, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474, ChEBI:CHEBI:57502, ChEBI:CHEBI:58017, ChEBI:CHEBI:456216; EC=6.3.4.21;
PATHWAY	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D- ribonucleotide from nicotinate: step 1/1.
case <FTTag:phospho>
PTM	Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.
end case
SIMILARITY	Belongs to the NAPRTase family.

Keywords [?]

Ligase
Pyridine nucleotide biosynthesis
case <FTTag:phospho>
Phosphoprotein
end case

Gene Ontology [?]

GO:0004516; Molecular function:nicotinate phosphoribosyltransferase activity

GO:0009435; Biological process:NAD biosynthetic process

Cross-references [?]

Features [?]

From: PNCB_SALTY (P22253)

Key

From

Description

Tag

Condition

FTGroup

MOD_RES

220

/note="Phosphohistidine; by autocatalysis"

phospho

Additional information [?]