HAMAP rule MF_00570
General rule information
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Accession | MF_00570 |
Dates | 5-JUL-2002 (Created) 1-JUN-2023 (Last updated, Version 33) |
Name | NAPRTase |
Scope | Bacteria
Archaea |
Templates | P18133 (PNCB_ECOLI); P22253 (PNCB_SALTY): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. |
Catalytic activity | RHEA:36163: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate
EC 6.3.4.21 |
Pathway | Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. |
case <FTTag:phospho>
Ptm | Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. |
end case
Similarity | Belongs to the NAPRTase family. |
Keywords
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case <FTTag:phospho>
end case
Gene Ontology
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GO:0004516; Molecular function: nicotinate phosphoribosyltransferase activity.
GO:0009435; Biological process: NAD biosynthetic process.
GO:0009435; Biological process: NAD biosynthetic process.
Cross-references
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Pfam | PF04095; NAPRTase; 1; |
PIRSF | PIRSF000484; NAPRT; 1; |
NCBIfam | TIGR01514; NAPRTase; 1; |
Features
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From: PNCB_SALTY (P22253) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOD_RES | 220 | 220 | Phosphohistidine; by autocatalysis | phospho | H |
Additional information
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Size range | 389-437 amino acids |
Related rules | None |
Fusion | None |