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Annotation rule MF_00570
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General rule information [?]

Accession MF_00570
Dates 5-JUL-2002 (Created)
18-NOV-2019 (Last updated, Version 32)
Name NAPRTase
Scope
Bacteria
Archaea
Templates P18133 (PNCB_ECOLI); P22253 (PNCB_SALTY): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PNCB
Protein name
RecName: Full=Nicotinate phosphoribosyltransferase;
Short=NAPRTase;
EC 6.3.4.21;
Gene name
pncB

Comments [?]

Function Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
Catalytic activity RHEA:36163: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate
EC 6.3.4.21
Pathway Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.
case <FTTag:phospho>
Ptm Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.
end case
Similarity Belongs to the NAPRTase family.

Keywords [?]

case <FTTag:phospho>
end case

Gene Ontology [?]

GO:0004516; Molecular function: nicotinate phosphoribosyltransferase activity.
GO:0009435; Biological process: NAD biosynthetic process.

Cross-references [?]

Pfam PF04095; NAPRTase; 1;
PIRSF PIRSF000484; NAPRT; 1;
TIGRFAMs TIGR01514; NAPRTase; 1;

Features [?]

From: PNCB_SALTY (P22253)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     220     220       Phosphohistidine; by autocatalysis   phospho   H  

Additional information [?]

Size range 389-437 amino acids
Related rules None
Fusion None