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HAMAP rule MF_00570

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General rule information [?]

Accession MF_00570
Dates 5-JUL-2002 (Created)
1-JUN-2023 (Last updated, Version 33)
Name NAPRTase
Scope(s) Bacteria
Template(s) P18133 (PNCB_ECOLI); P22253 (PNCB_SALTY); [ Recover all ]
Triggered by HAMAP; MF_00570 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PNCB
Protein name RecName: Full=Nicotinate phosphoribosyltransferase;
Gene name Name=pncB;

Comments [?]

FUNCTIONCatalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
CATALYTIC ACTIVITY Reaction=5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate; Xref=Rhea:RHEA:36163, ChEBI:CHEBI:15377, ChEBI:CHEBI:30616, ChEBI:CHEBI:32544, ChEBI:CHEBI:33019, ChEBI:CHEBI:43474, ChEBI:CHEBI:57502, ChEBI:CHEBI:58017, ChEBI:CHEBI:456216; EC=;
PATHWAYCofactor biosynthesis; NAD(+) biosynthesis; nicotinate D- ribonucleotide from nicotinate: step 1/1.
case <FTTag:phospho>
PTMTransiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.
end case
SIMILARITYBelongs to the NAPRTase family.

Keywords [?]

Gene Ontology [?]

GO:0004516; Molecular function:nicotinate phosphoribosyltransferase activity
GO:0009435; Biological process:NAD biosynthetic process

Cross-references [?]

Pfam PF04095; NAPRTase; 1;
NCBIfam TIGR01514; NAPRTase; 1;

Features [?]

From: PNCB_SALTY (P22253)
Key From To Description Tag Condition FTGroup
MOD_RES 220 220 /note="Phosphohistidine; by autocatalysis" phospho H

Additional information [?]

Size range 389-437 amino acids
Related rules None
Fusion Nter: None Cter: None

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