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| Annotation rule MF_00572 |
General rule information
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| Accession | MF_00572 |
| Dates | 12-JUL-2002 (Created) 18-NOV-2019 (Last updated, Version 30) |
| Name | LeuA_type2 |
| Scope | Bacteria |
| Templates | P42455 (LEU1_CORGL); P9WQB3 (LEU1_MYCTU): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). |
| Catalytic activity | RHEA:21524: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)
EC 2.3.3.13 |
| Pathway | Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4. |
| Subunit | Homotetramer. |
| Similarity | Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. |
Keywords
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Gene Ontology
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GO:0003852; Molecular function: 2-isopropylmalate synthase activity.
GO:0009098; Biological process: leucine biosynthetic process.
GO:0009098; Biological process: leucine biosynthetic process.
Cross-references
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| Pfam | PF00682; HMGL-like; 1; |
| TIGRFAMs | TIGR00970; LeuA_yeast; 1; |
| PROSITE | PS00815; AIPM_HOMOCIT_SYNTH_1; 1; |
| PS00816; AIPM_HOMOCIT_SYNTH_2; 1; | |
| PS50991; PYR_CT; 1; trigger=PRU01151; |
Additional information
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| Size range | 530-675 amino acids |
| Related rules | MF_01025 (LEU1); MF_01028 (CIMA) |
| Fusion | None |
| Comments | Weird insertion in MYCBO and MYCTU (not shown in alignment and not used in size range) |