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HAMAP rule MF_00578

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General rule information [?]

Accession MF_00578
Dates 27-AUG-2002 (Created)
1-JUN-2023 (Last updated, Version 23)
Name Glu_cys_ligase
Scope(s) Bacteria
Template(s) P0A6W9 (GSH1_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00578 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GSH1
Protein name RecName: Full=Glutamate--cysteine ligase;
AltName: Full=Gamma-ECS;
AltName: Full=Gamma-glutamylcysteine synthetase;
Gene name Name=gshA;

Comments [?]

CATALYTIC ACTIVITY Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L- cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235, ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=;
PATHWAYSulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.
SIMILARITYBelongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004357; Molecular function:glutamate-cysteine ligase activity
GO:0006750; Biological process:glutathione biosynthetic process

Cross-references [?]

Pfam PF04262; Glu_cys_ligase; 1;
NCBIfam TIGR01434; Glu_cys_ligase; 1;

Features [?]

Additional information [?]

Size range 505-535 amino acids
Related rules MF_00782
Fusion Nter: None Cter: None

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