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| Annotation rule MF_00578 |
General rule information
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| Accession | MF_00578 |
| Dates | 27-AUG-2002 (Created) 18-NOV-2019 (Last updated, Version 21) |
| Name | Glu_cys_ligase |
| Scope | Bacteria |
| Template | P0A6W9 (GSH1_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Catalytic activity | RHEA:13285: ATP + L-cysteine + L-glutamate = ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate
EC 6.3.2.2 |
| Pathway | Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. |
| Similarity | Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. |
Keywords
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Gene Ontology
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GO:0004357; Molecular function: glutamate-cysteine ligase activity.
GO:0006750; Biological process: glutathione biosynthetic process.
GO:0006750; Biological process: glutathione biosynthetic process.
Cross-references
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Additional information
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| Size range | 505-535 amino acids |
| Related rules | MF_00782 (GSHAB) |
| Fusion | None |