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Annotation rule MF_00578
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General rule information [?]

Accession MF_00578
Dates 27-AUG-2002 (Created)
18-NOV-2019 (Last updated, Version 21)
Name Glu_cys_ligase
Scope
Bacteria
Template P0A6W9 (GSH1_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GSH1
Protein name
RecName: Full=Glutamate--cysteine ligase;
EC 6.3.2.2;
AltName: Full=Gamma-ECS;
Short=GCS;
AltName: Full=Gamma-glutamylcysteine synthetase;
Gene name
gshA

Comments [?]

Catalytic activity RHEA:13285: ATP + L-cysteine + L-glutamate = ADP + H(+) + L-gamma-glutamyl-L-cysteine + phosphate
EC 6.3.2.2
Pathway Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.
Similarity Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004357; Molecular function: glutamate-cysteine ligase activity.
GO:0006750; Biological process: glutathione biosynthetic process.

Cross-references [?]

Pfam PF04262; Glu_cys_ligase; 1;
TIGRFAMs TIGR01434; Glu_cys_ligase; 1;

Additional information [?]

Size range 505-535 amino acids
Related rules MF_00782 (GSHAB)
Fusion None