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Annotation rule MF_00581 |
Accession | MF_00581 |
Dates | 17-OCT-2002 (Created) 18-NOV-2019 (Last updated, Version 37) |
Name | Arg_succ_synth_type2 |
Scope | Bacteria |
Template | P0A6E4 (ASSY_ECOLI) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Catalytic activity | RHEA:10932: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
EC 6.3.4.5 |
Pathway | Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. |
Subunit | Homotetramer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the argininosuccinate synthase family. Type 2 subfamily. |
Pfam | PF00764; Arginosuc_synth; 1; |
TIGRFAMs | TIGR00032; ArgG; 1; |
PROSITE | PS00564; ARGININOSUCCIN_SYN_1; 1; |
PS00565; ARGININOSUCCIN_SYN_2; 1; |
From: ASSY_ECOLI (P0A6E4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 17 | 25 | ATP | |||||||||
BINDING | 43 | 43 | ATP; via amide nitrogen and carbonyl oxygen | A | ||||||||
BINDING | 99 | 99 | Citrulline | Y | ||||||||
BINDING | 129 | 129 | ATP; via amide nitrogen | G | ||||||||
BINDING | 131 | 131 | ATP | T | ||||||||
BINDING | 131 | 131 | Aspartate | T | ||||||||
BINDING | 135 | 135 | Citrulline | N | ||||||||
BINDING | 135 | 135 | Aspartate | N | ||||||||
BINDING | 136 | 136 | ATP | D | ||||||||
BINDING | 136 | 136 | Aspartate | D | ||||||||
BINDING | 139 | 139 | Citrulline | R | ||||||||
BINDING | 192 | 192 | Citrulline | S | ||||||||
BINDING | 194 | 194 | ATP | D | ||||||||
BINDING | 201 | 201 | Citrulline | T | ||||||||
BINDING | 203 | 203 | Citrulline | E | ||||||||
BINDING | 280 | 280 | Citrulline | E |
Size range | 444-482 amino acids |
Related rules | MF_00005 (ASSY) |
Fusion | None |
Comments | Argininosuccinate synthase type 1 subfamily in MF_00005. |