Home  |  Contact
Annotation rule MF_00581
Send feedback

General rule information [?]

Accession MF_00581
Dates 17-OCT-2002 (Created)
18-NOV-2019 (Last updated, Version 37)
Name Arg_succ_synth_type2
Scope
Bacteria
Template P0A6E4 (ASSY_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ASSY
Protein name
RecName: Full=Argininosuccinate synthase;
EC 6.3.4.5;
AltName: Full=Citrulline--aspartate ligase;
Gene name
argG

Comments [?]

Catalytic activity RHEA:10932: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
EC 6.3.4.5
Pathway Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
Subunit Homotetramer.
Subcellular location Cytoplasm.
Similarity Belongs to the argininosuccinate synthase family. Type 2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004055; Molecular function: argininosuccinate synthase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00764; Arginosuc_synth; 1;
TIGRFAMs TIGR00032; ArgG; 1;
PROSITE PS00564; ARGININOSUCCIN_SYN_1; 1;
PS00565; ARGININOSUCCIN_SYN_2; 1;

Features [?]

From: ASSY_ECOLI (P0A6E4)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     17     25       ATP        
BINDING     43     43       ATP; via amide nitrogen and carbonyl oxygen     A  
BINDING     99     99       Citrulline     Y  
BINDING     129     129       ATP; via amide nitrogen     G  
BINDING     131     131       ATP     T  
BINDING     131     131       Aspartate     T  
BINDING     135     135       Citrulline     N  
BINDING     135     135       Aspartate     N  
BINDING     136     136       ATP     D  
BINDING     136     136       Aspartate     D  
BINDING     139     139       Citrulline     R  
BINDING     192     192       Citrulline     S  
BINDING     194     194       ATP     D  
BINDING     201     201       Citrulline     T  
BINDING     203     203       Citrulline     E  
BINDING     280     280       Citrulline     E  

Additional information [?]

Size range 444-482 amino acids
Related rules MF_00005 (ASSY)
Fusion None
Comments Argininosuccinate synthase type 1 subfamily in MF_00005.