HAMAP rule MF_00581

General rule information [?]

Accession	MF_00581
Dates	17-OCT-2002 (Created) 1-JUN-2023 (Last updated, Version 40)

Name	Arg_succ_synth_type2

Scope

Bacteria

Template

P0A6E4 (ASSY_ECOLI)

Triggered by

HAMAP; MF_00581 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ASSY

Protein name

RecName:		Full=Argininosuccinate synthase;
		EC 6.3.4.5;
AltName:		Full=Citrulline--aspartate ligase;

Gene name

argG

Comments [?]

Catalytic activity	RHEA:10932: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) EC 6.3.4.5
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
Subunit	Homotetramer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the argininosuccinate synthase family. Type 2 subfamily.

Keywords [?]

Cytoplasm
Amino-acid biosynthesis
Arginine biosynthesis
Ligase
ATP-binding
Nucleotide-binding

Gene Ontology [?]

GO:0004055; Molecular function: argininosuccinate synthase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00764; Arginosuc_synth; 1;
NCBIfam	TIGR00032; ArgG; 1;
PROSITE	PS00564; ARGININOSUCCIN_SYN_1; 1;
	PS00565; ARGININOSUCCIN_SYN_2; 1;

Features [?]

From: ASSY_ECOLI (P0A6E4)

Key From To Description Tag Condition FTGroup

BINDING 17 25 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616

BINDING 43 43 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 A

BINDING 99 99 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 Y

BINDING 129 129 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G

BINDING 131 131 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 T

BINDING 131 131 /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991 T

BINDING 135 135 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 N

BINDING 135 135 /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991 N

BINDING 136 136 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 D

BINDING 136 136 /ligand="L-aspartate" /ligand_id="ChEBI:CHEBI:29991 D

BINDING 139 139 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 R

BINDING 192 192 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 S

BINDING 194 194 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 D

BINDING 201 201 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 T

BINDING 203 203 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 E

BINDING 280 280 /ligand="L-citrulline" /ligand_id="ChEBI:CHEBI:57743 E

Additional information [?]

Size range	444-482 amino acids
Related rules	MF_00005 (ASSY)
Fusion	None
Comments	Argininosuccinate synthase type 1 subfamily in MF_00005.

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