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| Annotation rule MF_00581 |
General rule information
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| Accession | MF_00581 |
| Dates | 17-OCT-2002 (Created) 18-NOV-2019 (Last updated, Version 37) |
| Name | Arg_succ_synth_type2 |
| Scope | Bacteria |
| Template | P0A6E4 (ASSY_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Catalytic activity | RHEA:10932: ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)
EC 6.3.4.5 |
| Pathway | Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. |
| Subunit | Homotetramer. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the argininosuccinate synthase family. Type 2 subfamily. |
Keywords
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Gene Ontology
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GO:0004055; Molecular function: argininosuccinate synthase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF00764; Arginosuc_synth; 1; |
| TIGRFAMs | TIGR00032; ArgG; 1; |
| PROSITE | PS00564; ARGININOSUCCIN_SYN_1; 1; |
| PS00565; ARGININOSUCCIN_SYN_2; 1; |
Features
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| From: ASSY_ECOLI (P0A6E4) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND | 17 | 25 | ATP | |||||||||
| BINDING | 43 | 43 | ATP; via amide nitrogen and carbonyl oxygen | A | ||||||||
| BINDING | 99 | 99 | Citrulline | Y | ||||||||
| BINDING | 129 | 129 | ATP; via amide nitrogen | G | ||||||||
| BINDING | 131 | 131 | ATP | T | ||||||||
| BINDING | 131 | 131 | Aspartate | T | ||||||||
| BINDING | 135 | 135 | Citrulline | N | ||||||||
| BINDING | 135 | 135 | Aspartate | N | ||||||||
| BINDING | 136 | 136 | ATP | D | ||||||||
| BINDING | 136 | 136 | Aspartate | D | ||||||||
| BINDING | 139 | 139 | Citrulline | R | ||||||||
| BINDING | 192 | 192 | Citrulline | S | ||||||||
| BINDING | 194 | 194 | ATP | D | ||||||||
| BINDING | 201 | 201 | Citrulline | T | ||||||||
| BINDING | 203 | 203 | Citrulline | E | ||||||||
| BINDING | 280 | 280 | Citrulline | E | ||||||||
Additional information
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| Size range | 444-482 amino acids |
| Related rules | MF_00005 (ASSY) |
| Fusion | None |
| Comments | Argininosuccinate synthase type 1 subfamily in MF_00005. |