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HAMAP rule MF_00588

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General rule information [?]

Accession MF_00588
Dates 22-OCT-2002 (Created)
1-JUN-2023 (Last updated, Version 21)
Name GatE
Scope(s) Archaea
Template(s) O26803 (GATE_METTH); [ Recover all ]
Triggered by HAMAP; MF_00588 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GATE
Protein name RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit E;
                 Short=Glu-ADT subunit E;
Gene name Name=gatE;

Comments [?]

FUNCTIONAllows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
CATALYTIC ACTIVITY Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate; Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216;
SUBUNITHeterodimer of GatD and GatE.
SIMILARITYBelongs to the GatB/GatE family. GatE subfamily.

Keywords [?]

Gene Ontology [?]

GO:0050567; Molecular function:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
GO:0006412; Biological process:translation

Cross-references [?]

Pfam PF02938; GAD; 1;
Pfam PF02934; GatB_N; 1;
Pfam PF02637; GatB_Yqey; 1;
NCBIfam TIGR00134; GatE_arch; 1;

Features [?]

Additional information [?]

Size range 598-642 amino acids
Related rules MF_00121
Fusion Nter: None Cter: None

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