HAMAP rule MF_00588

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00588
Accession	MF_00588
Dates	28-FEB-2005 (Created) 03-SEP-2024 (Last updated, Version 17)
Name	GatE
Scope(s)	Archaea
Template(s)	O26803; [ Recover all ]
Triggered by	HAMAP; MF_00588 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GATE
Protein name	RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit E; Short=Glu-ADT subunit E; EC=6.3.5.-;
Gene name	Name=gatE;

Comments [?]

FUNCTION	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
CATALYTIC ACTIVITY	Reaction=L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl- tRNA(Gln) + L-glutamate + ADP + phosphate + H(+); Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216;
SUBUNIT	Heterodimer of GatD and GatE.
SIMILARITY	Belongs to the GatB/GatE family. GatE subfamily.

Keywords [?]

Gene Ontology [?]

GO:0050567; Molecular function:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

GO:0006412; Biological process:translation

Cross-references [?]

Features [?]

Additional information [?]