HAMAP rule MF_00592

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00592
Accession	MF_00592
Dates	28-FEB-2005 (Created) 03-SEP-2024 (Last updated, Version 25)
Name	DeoC_type2
Scope(s)	Bacteria
Template(s)	P0A6L0; Q8ZJV8; [ Recover all ]
Triggered by	HAMAP; MF_00592 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DEOC
Protein name	RecName: Full=Deoxyribose-phosphate aldolase; Short=DERA; EC=4.1.2.4; AltName: Full=2-deoxy-D-ribose 5-phosphate aldolase; AltName: Full=Phosphodeoxyriboaldolase; Short=Deoxyriboaldolase;
Gene name	Name=deoC;

Comments [?]

FUNCTION	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate.
CATALYTIC ACTIVITY	Reaction=2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde; Xref=Rhea:RHEA:12821, ChEBI:CHEBI:15343, ChEBI:CHEBI:59776, ChEBI:CHEBI:62877; EC=4.1.2.4;
PATHWAY	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate: step 2/2.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004139; Molecular function:deoxyribose-phosphate aldolase activity

GO:0006018; Biological process:2-deoxyribose 1-phosphate catabolic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam	PF01791; DeoC; 1;
NCBIfam	TIGR00126; deoC; 1;

Features [?]

From: DEOC_ECOLI (P0A6L0)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

102

/note="Proton donor/acceptor"

[DE]

ACT_SITE

167

/note="Schiff-base intermediate with acetaldehyde"

ACT_SITE

201

/note="Proton donor/acceptor"

Additional information [?]