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HAMAP rule MF_00592

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General rule information [?]

Accession MF_00592
Dates 1-NOV-2002 (Created)
24-JAN-2024 (Last updated, Version 35)
Name DeoC_type2
Scope(s) Bacteria
Template(s) P0A6L0 (DEOC_ECOLI); Q8ZJV8 (DEOC_SALTY); [ Recover all ]
Triggered by HAMAP; MF_00592 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DEOC
Protein name RecName: Full=Deoxyribose-phosphate aldolase;
AltName: Full=2-deoxy-D-ribose 5-phosphate aldolase;
AltName: Full=Phosphodeoxyriboaldolase;
Gene name Name=deoC;

Comments [?]

FUNCTIONCatalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate.
CATALYTIC ACTIVITY Reaction=2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate; Xref=Rhea:RHEA:12821, ChEBI:CHEBI:15343, ChEBI:CHEBI:59776, ChEBI:CHEBI:62877; EC=;
PATHWAYCarbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate: step 2/2.
SIMILARITYBelongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004139; Molecular function:deoxyribose-phosphate aldolase activity
GO:0006018; Biological process:2-deoxyribose 1-phosphate catabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01791; DeoC; 1;
NCBIfam TIGR00126; deoC; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 102 102 /note="Proton donor/acceptor" [DE]
ACT_SITE 167 167 /note="Schiff-base intermediate with acetaldehyde" K
ACT_SITE 201 201 /note="Proton donor/acceptor" K

Additional information [?]

Size range 210-325 amino acids
Related rules MF_00114
Fusion Nter: None Cter: None

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