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HAMAP rule MF_00600

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General rule information [?]

Accession MF_00600
Dates 15-NOV-2002 (Created)
1-JUN-2023 (Last updated, Version 76)
Name CH60
Scope
Bacteria
Archaea; Methanococcales
Archaea; Methanomicrobiales
Archaea; Methanosarcinaceae
Archaea; Methanospirillaceae
Plastid
Templates P0A6F5 (CH60_ECOLI); P61491 (CH60_THETH); P31293 (CH60_ALLVI); Q60024 (CH60_THEBR): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CH60
case not <OG:Chloroplast>
Protein name
RecName: Full=Chaperonin GroEL;
EC 5.6.1.7;
AltName: Full=60 kDa chaperonin;
AltName: Full=Chaperonin-60;
Short=Cpn60;
else case <OG:Chloroplast>
Protein name
RecName: Full=Chaperonin GroEL, chloroplastic;
EC 5.6.1.7;
AltName: Full=60 kDa chaperonin;
AltName: Full=Chaperonin-60;
Short=Cpn60;
end case
Gene name
groEL, groL

Comments [?]

Function Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Catalytic activity Reaction=ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.; EC=5.6.1.7;
Subunit Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
case <OC:Bacteria> or <OC:Archaea>
Subcellular location Cytoplasm.
end case
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast.
end case
Similarity Belongs to the chaperonin (HSP60) family.

Keywords [?]

case <OC:Bacteria> or <OC:Archaea>
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0051082; Molecular function: unfolded protein binding.
GO:0042026; Biological process: protein refolding.
case <OC:Bacteria> or <OC:Archaea>
GO:0005737; Cellular component: cytoplasm.
end case
case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Cross-references [?]

Pfam PF00118; Cpn60_TCP1; 1;
PRINTS PR00298; CHAPERONIN60; 1;
NCBIfam TIGR02348; GroEL; 1;
PROSITE PS00296; CHAPERONINS_CPN60; 1;

Features [?]

From: CH60_ECOLI (P0A6F5)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     30     33       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     T-x-[GA]-P  
BINDING (Optional)     87     91       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     D-G-T-T-T  
BINDING (Optional)     479     481       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [ND]-[AV]-[AVL]  
BINDING (Optional)     51     51       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     K  
BINDING (Optional)     415     415       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G  
BINDING (Optional)     495     495       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     D  

Additional information [?]

Size range 470-620 amino acids
Related rules None
Fusion None