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HAMAP rule MF_00600

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General rule information [?]

Accession MF_00600
Dates 15-NOV-2002 (Created)
1-JUN-2023 (Last updated, Version 76)
Name CH60
Scope(s) Bacteria
Archaea
Methanococcales
Methanomicrobiales
Methanosarcinaceae
Methanospirillaceae
Plastid
Template(s) P0A6F5 (CH60_ECOLI); P61491 (CH60_THETH); P31293 (CH60_ALLVI); Q60024 (CH60_THEBR); [ Recover all ]
Triggered by HAMAP; MF_00600 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CH60
case not <OG:Chloroplast>
Protein name RecName: Full=Chaperonin GroEL;
                 EC=5.6.1.7;
AltName: Full=60 kDa chaperonin;
AltName: Full=Chaperonin-60;
                 Short=Cpn60;
else case <OG:Chloroplast>
Protein name RecName: Full=Chaperonin GroEL, chloroplastic;
                 EC=5.6.1.7;
AltName: Full=60 kDa chaperonin;
AltName: Full=Chaperonin-60;
                 Short=Cpn60;
end case
Gene name Name=groEL; Synonyms=groL;

Comments [?]

FUNCTIONTogether with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano- cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
CATALYTIC ACTIVITY Reaction=ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.; EC=5.6.1.7;
SUBUNITForms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
case <OC:Bacteria> or <OC:Archaea>
SUBCELLULAR LOCATIONCytoplasm.
end case
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
SIMILARITYBelongs to the chaperonin (HSP60) family.

Keywords [?]

ATP-binding
Chaperone
case <OC:Bacteria> or <OC:Archaea>
Cytoplasm
end case
Isomerase
Nucleotide-binding

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0051082; Molecular function:unfolded protein binding
GO:0042026; Biological process:protein refolding
case <OCellular component:Bacteria> or <OC:Archaea>
GO:0005737; Cellular component:cytoplasm
end case
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

Pfam PF00118; Cpn60_TCP1; 1;
PRINTS PR00298; CHAPERONIN60; 1;
NCBIfam TIGR02348; GroEL; 1;
PROSITE PS00296; CHAPERONINS_CPN60; 1;

Features [?]

From: CH60_ECOLI (P0A6F5)
Key From To Description Tag Condition FTGroup
BINDING 30 33 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
T-x-[GA]-P
BINDING 87 91 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
D-G-T-T-T
BINDING 479 481 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
[ND]-[AV]-[AVL]
BINDING 51 51 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
K
BINDING 415 415 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G
BINDING 495 495 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
D

Additional information [?]

Size range 470-620 amino acids
Related rules None
Fusion Nter: None Cter: None



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