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HAMAP rule MF_00605

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General rule information [?]

Accession MF_00605
Dates 29-NOV-2002 (Created)
13-OCT-2023 (Last updated, Version 30)
Name TrmD
Scope(s) Bacteria
Template(s) P0A873 (TRMD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00605 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRMD
Protein name RecName: Full=tRNA (guanine-N(1)-)-methyltransferase;
AltName: Full=M1G-methyltransferase;
AltName: Full=tRNA [GM37] methyltransferase;
Gene name Name=trmD;

Comments [?]

FUNCTIONSpecifically methylates guanosine-37 in various tRNAs.
CATALYTIC ACTIVITY Reaction=guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)- methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:36899, Rhea:RHEA-COMP:10145, Rhea:RHEA-COMP:10147, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=;
SIMILARITYBelongs to the RNA methyltransferase TrmD family.

Keywords [?]

Gene Ontology [?]

GO:0052906; Molecular function:tRNA (guanine(37)-N1)-methyltransferase activity
GO:0006400; Biological process:tRNA modification
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01746; tRNA_m1G_MT; 1;
NCBIfam TIGR00088; TrmD; 1;

Features [?]

From: TRMD_ECOLI (P0A873)
Key From To Description Tag Condition FTGroup
BINDING 133 138 /ligand="S-adenosyl-L-methionine"
BINDING 113 113 /ligand="S-adenosyl-L-methionine"

Additional information [?]

Size range 222-361 amino acids
Related rules None
Fusion Nter: None Cter: <Unknown>

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