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HAMAP rule MF_00608

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General rule information [?]

Accession MF_00608
Dates 10-DEC-2002 (Created)
18-NOV-2019 (Last updated, Version 25)
Name GTP_cyclohydro_3
Scope(s) Archaea
Template(s) Q57609 (GCH3_METJA); [ Recover all ]
Triggered by HAMAP; MF_00608 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GCH3
Protein name RecName: Full=GTP cyclohydrolase III;
Gene name Name=gch3;

Comments [?]

FUNCTIONCatalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.
CATALYTIC ACTIVITY Reaction=GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D- ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:22468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57258; EC=;
SIMILARITYBelongs to the archaeal-type GTP cyclohydrolase family.

Keywords [?]

Gene Ontology [?]

GO:0016814; Molecular function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Cross-references [?]

Pfam PF05165; GGDN; 1;
PIRSF PIRSF009265; GTP_cyclohydro_3; 1;

Features [?]

Additional information [?]

Size range 221-268 amino acids
Related rules None
Fusion Nter: None Cter: None

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