HAMAP rule MF_00608
General rule information
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Accession | MF_00608 |
Dates | 10-DEC-2002 (Created)
2-SEP-2024 (Last updated, Version 26) |
Name | GTP_cyclohydro_3 |
Scope(s) |
Archaea |
Template(s) | Q57609 (GCH3_METJA); [ Recover all ] |
Triggered by |
HAMAP; MF_00608 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GCH3 |
Protein name | RecName: Full=GTP cyclohydrolase III; EC=3.5.4.29; |
Gene name | Name=gch3; |
Comments
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FUNCTION | Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity. |
CATALYTIC ACTIVITY | Reaction=GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D- ribosylamino)pyrimidin-4(3H)-one + 2 phosphate + 2 H(+); Xref=Rhea:RHEA:22468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57258; EC=3.5.4.29; |
SIMILARITY | Belongs to the archaeal-type GTP cyclohydrolase family. |
Keywords
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Gene Ontology
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GO:0016814; Molecular function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines |
Cross-references
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Pfam | PF05165; GGDN; 1; |
PIRSF | PIRSF009265; GTP_cyclohydro_3; 1; |
Features
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Additional information
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Size range | 221-268 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |