HAMAP rule MF_00608

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00608
Accession	MF_00608
Dates	10-DEC-2002 (Created) 2-SEP-2024 (Last updated, Version 26)
Name	GTP_cyclohydro_3
Scope(s)	Archaea
Template(s)	Q57609 (GCH3_METJA); [ Recover all ]
Triggered by	HAMAP; MF_00608 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GCH3
Protein name	RecName: Full=GTP cyclohydrolase III; EC=3.5.4.29;
Gene name	Name=gch3;

Comments [?]

FUNCTION	Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.
CATALYTIC ACTIVITY	Reaction=GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D- ribosylamino)pyrimidin-4(3H)-one + 2 phosphate + 2 H(+); Xref=Rhea:RHEA:22468, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:57258; EC=3.5.4.29;
SIMILARITY	Belongs to the archaeal-type GTP cyclohydrolase family.

Keywords [?]

Gene Ontology [?]

GO:0016814; Molecular function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

Cross-references [?]

Pfam	PF05165; GGDN; 1;
PIRSF	PIRSF009265; GTP_cyclohydro_3; 1;

Features [?]

Additional information [?]