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| Annotation rule MF_00608 |
General rule information
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| Accession | MF_00608 |
| Dates | 10-DEC-2002 (Created) 18-NOV-2019 (Last updated, Version 25) |
| Name | GTP_cyclohydro_3 |
| Scope | Archaea |
| Template | Q57609 (GCH3_METJA) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity. |
| Catalytic activity | RHEA:22468: GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate
EC 3.5.4.29 |
| Similarity | Belongs to the archaeal-type GTP cyclohydrolase family. |
Keywords
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Gene Ontology
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GO:0016814; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines.
Cross-references
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| Pfam | PF05165; GGDN; 1; |
| PIRSF | PIRSF009265; GTP_cyclohydro_3; 1; |
Additional information
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| Size range | 221-268 amino acids |
| Related rules | None |
| Fusion | None |