HAMAP rule MF_00608

General rule information [?]

Accession	MF_00608
Dates	10-DEC-2002 (Created) 18-NOV-2019 (Last updated, Version 25)

Name	GTP_cyclohydro_3

Scope

Archaea

Template

Q57609 (GCH3_METJA)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GCH3

Protein name

RecName:		Full=GTP cyclohydrolase III;
		EC 3.5.4.29;

Gene name

gch3

Comments [?]

Function	Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.
Catalytic activity	RHEA:22468: GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 H(+) + 2 phosphate EC 3.5.4.29
Similarity	Belongs to the archaeal-type GTP cyclohydrolase family.

Keywords [?]

Gene Ontology [?]

GO:0016814; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines.

Cross-references [?]

Pfam	PF05165; GGDN; 1;
PIRSF	PIRSF009265; GTP_cyclohydro_3; 1;

Additional information [?]