HAMAP rule MF_00632
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00632 |
| Accession | MF_00632 |
| Dates | 28-FEB-2005 (Created)
21-FEB-2025 (Last updated, Version 16) |
| Name | YajQ |
| Scope(s) |
Bacteria |
| Template(s) | Q4UQD0; Q8ZRC9; P0A8E7; [ Recover all ] |
| Triggered by |
HAMAP; MF_00632 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | |
| Identifier | YAJQ |
| Protein name | RecName: Full=Nucleotide-binding protein YajQ; |
| Gene name | Name=yajQ; |
| else | |
| Identifier | Ynnn |
| Protein name | RecName: Full=Nucleotide-binding protein |
| end case | |
Comments
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| FUNCTION | Nucleotide-binding protein. |
| SIMILARITY | Belongs to the YajQ family. |
Keywords
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Gene Ontology
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| GO:0000166; Molecular function:nucleotide binding |
Cross-references
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| Pfam | PF04461; DUF520; 1; |
Features
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Additional information
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| Size range | 159-169 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Some members have been shown to bind cyclic di-GMP and are involved in the regulation of cellular functions, including virulence. However, An et al. show that not all members of the YajQ family preferentially bind cyclic di-GMP, suggesting that they have other cellular roles. This contention is supported by the observation that YajQ family members are found in bacteria that do not apparently have cyclic di-GMP signaling, such as H.influenzae. Further work will be required to identify residues that are critical for cyclic di-GMP binding, which may then allow bioinformatic discrimination of those family members that have this capability. (see PubMed:25329577). |