HAMAP rule MF_00635

General rule information [?]

Accession	MF_00635
Dates	16-APR-2003 (Created) 18-NOV-2019 (Last updated, Version 14)

Name	dUTPase_arch

Scope

Archaea

Template

Q58502 (DUT_METJA)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

DUT

Protein name

RecName:		Full=Probable deoxyuridine 5'-triphosphate nucleotidohydrolase;
		Short=dUTPase;
		EC 3.6.1.23;
AltName:		Full=dUTP pyrophosphatase;

Gene name

dut

Comments [?]

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Catalytic activity	RHEA:10248: dUTP + H2O = diphosphate + dUMP + H(+) EC 3.6.1.23
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
Similarity	Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004170; Molecular function: dUTP diphosphatase activity.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.

Cross-references [?]

Pfam	PF00692; dUTPase; 1;

Additional information [?]