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| Annotation rule MF_00635 |
General rule information
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| Accession | MF_00635 |
| Dates | 16-APR-2003 (Created) 18-NOV-2019 (Last updated, Version 14) |
| Name | dUTPase_arch |
| Scope | Archaea |
| Template | Q58502 (DUT_METJA) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. |
| Catalytic activity | RHEA:10248: dUTP + H2O = diphosphate + dUMP + H(+)
EC 3.6.1.23 |
| Pathway | Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. |
| Similarity | Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily. |
Keywords
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Gene Ontology
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GO:0004170; Molecular function: dUTP diphosphatase activity.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.
Cross-references
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| Pfam | PF00692; dUTPase; 1; |
Additional information
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| Size range | 150-171 amino acids |
| Related rules | MF_00146 (DCDB) |
| Fusion | None |