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HAMAP rule MF_00635

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General rule information [?]

Accession MF_00635
Dates 16-APR-2003 (Created)
25-JAN-2024 (Last updated, Version 15)
Name dUTPase_arch
Scope(s) Archaea
Template(s) Q58502 (DUT_METJA); [ Recover all ]
Triggered by HAMAP; MF_00635 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DUT
Protein name RecName: Full=Probable deoxyuridine 5'-triphosphate nucleotidohydrolase;
AltName: Full=dUTP pyrophosphatase;
Gene name Name=dut;

Comments [?]

FUNCTIONThis enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
CATALYTIC ACTIVITY Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=;
PATHWAYPyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
SIMILARITYBelongs to the dCTP deaminase family. Archaeal dUTPase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004170; Molecular function:dUTP diphosphatase activity
GO:0006226; Biological process:dUMP biosynthetic process

Cross-references [?]

Pfam PF00692; dUTPase; 1;

Features [?]

Additional information [?]

Size range 150-171 amino acids
Related rules MF_00146
Fusion Nter: None Cter: None

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