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Annotation rule MF_00635 |
Accession | MF_00635 |
Dates | 16-APR-2003 (Created) 18-NOV-2019 (Last updated, Version 14) |
Name | dUTPase_arch |
Scope | Archaea |
Template | Q58502 (DUT_METJA) |
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Function | This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. |
Catalytic activity | RHEA:10248: dUTP + H2O = diphosphate + dUMP + H(+)
EC 3.6.1.23 |
Pathway | Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. |
Similarity | Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily. |
Pfam | PF00692; dUTPase; 1; |
Size range | 150-171 amino acids |
Related rules | MF_00146 (DCDB) |
Fusion | None |