HAMAP rule MF_00635
General rule information
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Accession |
MF_00635 |
Dates |
16-APR-2003 (Created) 18-NOV-2019 (Last updated, Version 14) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Probable deoxyuridine 5'-triphosphate nucleotidohydrolase;
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Short=dUTPase;
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EC 3.6.1.23;
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AltName:
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Full=dUTP pyrophosphatase;
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Function |
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. |
Catalytic activity |
RHEA:10248: dUTP + H2O = diphosphate + dUMP + H(+)
EC 3.6.1.23
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Pathway |
Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. |
Similarity |
Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily. |
GO:0004170; Molecular function: dUTP diphosphatase activity.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.
Additional information
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Size range |
150-171 amino acids |
Related rules |
MF_00146 (DCDB) |
Fusion |
None |