HAMAP rule MF_00635

General rule information [?]

Accession	MF_00635
Dates	16-APR-2003 (Created) 2-SEP-2024 (Last updated, Version 16)
Name	dUTPase_arch
Scope(s)	Archaea
Template(s)	Q58502 (DUT_METJA); [ Recover all ]
Triggered by	HAMAP; MF_00635 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DUT
Protein name	RecName: Full=Probable deoxyuridine 5'-triphosphate nucleotidohydrolase; Short=dUTPase; EC=3.6.1.23; AltName: Full=dUTP pyrophosphatase;
Gene name	Name=dut;

Comments [?]

FUNCTION	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
CATALYTIC ACTIVITY	Reaction=dUTP + H2O = dUMP + diphosphate + H(+); Xref=Rhea:RHEA:10248, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23;
PATHWAY	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.
SIMILARITY	Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004170; Molecular function:dUTP diphosphatase activity

GO:0006226; Biological process:dUMP biosynthetic process

Cross-references [?]

Pfam	PF00692; dUTPase; 1;

Features [?]

Additional information [?]