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HAMAP rule MF_00636

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General rule information [?]

Accession MF_00636
Dates 14-APR-2003 (Created)
19-NOV-2022 (Last updated, Version 35)
Name RapZ_like
Scope(s) Bacteria
Template(s) O06973 (YVCJ_BACSU); P0A894 (RAPZ_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00636 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Enterobacterales>
Identifier RAPZ
Protein name RecName: Full=RNase adapter protein RapZ;
Gene name Name=rapZ;
Identifier Ynnn
Protein name RecName: Full=Nucleotide-binding protein ;
end case

Comments [?]

case <OC:Enterobacterales>
FUNCTIONModulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.
SIMILARITYBelongs to the RapZ-like family. RapZ subfamily.
FUNCTIONDisplays ATPase and GTPase activities.
SIMILARITYBelongs to the RapZ-like family.
end case

Keywords [?]

case <OC:Enterobacterales>
end case

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0005525; Molecular function:GTP binding

Cross-references [?]

Pfam PF03668; ATP_bind_2; 1;
PIRSF PIRSF005052; P-loopkin; 1;

Features [?]

From: RAPZ_ECOLI (P0A894)
Key From To Description Tag Condition FTGroup
BINDING 8 15 /ligand="ATP"
BINDING 56 59 /ligand="GTP"
case <OC:Enterobacterales>
REGION 266 Cter /note="RNA-binding"
end case

Additional information [?]

Size range 261-372 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Homologs of RapZ are present in a wide range of bacteria indicating an important function. However, in bacteria that do not possess sRNAs GlmY and GlmZ, the role of RapZ homologs remains elusive. (see PubMed:24667238)

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