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HAMAP rule MF_00636

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General rule information [?]

Accession MF_00636
Dates 14-APR-2003 (Created)
19-NOV-2022 (Last updated, Version 35)
Name RapZ_like
Templates O06973 (YVCJ_BACSU); P0A894 (RAPZ_ECOLI): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Enterobacterales>
Protein name
RecName: Full=RNase adapter protein RapZ;
Gene name
Protein name
RecName: Full=Nucleotide-binding protein ;
end case

Comments [?]

case <OC:Enterobacterales>
Function Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.
Subunit Homotrimer.
Similarity Belongs to the RapZ-like family. RapZ subfamily.
Function Displays ATPase and GTPase activities.
Similarity Belongs to the RapZ-like family.
end case

Keywords [?]

case <OC:Enterobacterales>
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0005525; Molecular function: GTP binding.

Cross-references [?]

Pfam PF03668; ATP_bind_2; 1;
PIRSF PIRSF005052; P-loopkin; 1;

Features [?]

From: RAPZ_ECOLI (P0A894)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     8     15       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-x(2)-G-[SAG]-G-[KR]-x  
BINDING     56     59       /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565     D-x-R-x  
case <OC:Enterobacterales>
REGION     266     Cter       RNA-binding        
end case

Additional information [?]

Size range 261-372 amino acids
Related rules None
Fusion None
Comments Homologs of RapZ are present in a wide range of bacteria indicating an important function. However, in bacteria that do not possess sRNAs GlmY and GlmZ, the role of RapZ homologs remains elusive. (see PubMed:24667238)