HAMAP rule MF_00636
General rule information
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| Accession | MF_00636 |
| Dates | 14-APR-2003 (Created)
19-NOV-2022 (Last updated, Version 35) |
| Name | RapZ_like |
| Scope(s) |
Bacteria |
| Template(s) | O06973 (YVCJ_BACSU); P0A894 (RAPZ_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00636 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Enterobacterales> | |
| Identifier | RAPZ |
| Protein name | RecName: Full=RNase adapter protein RapZ; |
| Gene name | Name=rapZ; |
| else | |
| Identifier | Ynnn |
| Protein name | RecName: Full=Nucleotide-binding protein |
| end case | |
Comments
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| case <OC:Enterobacterales> | |
| FUNCTION | Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS. |
| SUBUNIT | Homotrimer. |
| SIMILARITY | Belongs to the RapZ-like family. RapZ subfamily. |
| else | |
| FUNCTION | Displays ATPase and GTPase activities. |
| SIMILARITY | Belongs to the RapZ-like family. |
| end case | |
Keywords
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| case <OC:Enterobacterales> | |
| RNA-binding | |
| end case | |
| ATP-binding | |
| GTP-binding | |
| Nucleotide-binding | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0005525; Molecular function:GTP binding |
Cross-references
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| Pfam | PF03668; ATP_bind_2; 1; |
| PIRSF | PIRSF005052; P-loopkin; 1; |
Features
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| From: RAPZ_ECOLI (P0A894) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 8 | 15 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x(2)-G-[SAG]-G-[KR]-x | ||||||||
| BINDING | 56 | 59 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
D-x-R-x | ||||||||
| case <OC:Enterobacterales> | ||||||||||||
| REGION | 266 | Cter | /note="RNA-binding" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 261-372 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Homologs of RapZ are present in a wide range of bacteria indicating an important function. However, in bacteria that do not possess sRNAs GlmY and GlmZ, the role of RapZ homologs remains elusive. (see PubMed:24667238) |