HAMAP rule MF_00637

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00637
Accession	MF_00637
Dates	28-FEB-2005 (Created) 02-SEP-2024 (Last updated, Version 19)
Name	Anti_sigma_F
Scope(s)	Bacteria Bacillales Clostridia
Template(s)	P10728; [ Recover all ]
Triggered by	HAMAP; MF_00637 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SP2AB
Protein name	RecName: Full=Anti-sigma F factor; EC=2.7.11.1; AltName: Full=Stage II sporulation protein AB;
Gene name	Name=spoIIAB;

Comments [?]

FUNCTION	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
CATALYTIC ACTIVITY	Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CATALYTIC ACTIVITY	Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;
SIMILARITY	Belongs to the anti-sigma-factor family.

Keywords [?]

Gene Ontology [?]

GO:0004672; Molecular function:protein kinase activity

GO:0010468; Biological process:regulation of gene expression

GO:0030436; Biological process:asexual sporulation

Cross-references [?]

Pfam	PF02518; HATPase_c; 1;
NCBIfam	TIGR01925; spIIAB; 1;

Features [?]

Additional information [?]