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HAMAP rule MF_00637

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General rule information [?]

Accession MF_00637
Dates 17-APR-2003 (Created)
1-JUN-2023 (Last updated, Version 20)
Name Anti_sigma_F
Scope(s) Bacteria
Template(s) P10728 (SP2AB_BACSU); [ Recover all ]
Triggered by HAMAP; MF_00637 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SP2AB
Protein name RecName: Full=Anti-sigma F factor;
AltName: Full=Stage II sporulation protein AB;
Gene name Name=spoIIAB;

Comments [?]

FUNCTIONBinds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
CATALYTIC ACTIVITY Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=;
CATALYTIC ACTIVITY Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=;
SIMILARITYBelongs to the anti-sigma-factor family.

Keywords [?]

Gene Ontology [?]

GO:0004672; Molecular function:protein kinase activity
GO:0010468; Biological process:regulation of gene expression
GO:0030436; Biological process:asexual sporulation

Cross-references [?]

Pfam PF02518; HATPase_c; 1;
NCBIfam TIGR01925; spIIAB; 1;

Features [?]

Additional information [?]

Size range 140-151 amino acids
Related rules MF_00638
Fusion Nter: None Cter: None

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