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HAMAP rule MF_00639

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General rule information [?]

Accession MF_00639
Dates 26-APR-2003 (Created)
1-JUN-2023 (Last updated, Version 35)
Name MurD
Scope(s) Bacteria
Template(s) P14900 (MURD_ECOLI); Q9HVZ9 (MURD_PSEAE); [ Recover all ]
Triggered by HAMAP; MF_00639 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MURD
Protein name RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase;
AltName: Full=D-glutamic acid-adding enzyme;
AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase;
Gene name Name=murD;

Comments [?]

FUNCTIONCell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
CATALYTIC ACTIVITY Reaction=ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D- glutamate; Xref=Rhea:RHEA:16429, ChEBI:CHEBI:15378, ChEBI:CHEBI:29986, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:83898, ChEBI:CHEBI:83900, ChEBI:CHEBI:456216; EC=;
PATHWAYCell wall biogenesis; peptidoglycan biosynthesis.
SIMILARITYBelongs to the MurCDEF family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0008764; Molecular function:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity
GO:0009252; Biological process:peptidoglycan biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01225; Mur_ligase; 1;
Pfam PF02875; Mur_ligase_C; 1;
NCBIfam TIGR01087; MurD; 1;

Features [?]

From: MURD_ECOLI (P14900)
Key From To Description Tag Condition FTGroup
BINDING 112 118 /ligand="ATP"

Additional information [?]

Size range 380-660 amino acids
Related rules MF_02208
Fusion Nter: None Cter: None
Comments Also matches MurD2 subfamily (MF_02208). Insertion in POLSJ (not shown in alignment and not used in size range)

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