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Annotation rule MF_00639
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General rule information [?]

Accession MF_00639
Dates 26-APR-2003 (Created)
18-NOV-2019 (Last updated, Version 32)
Name MurD
Scope
Bacteria
Templates P14900 (MURD_ECOLI); Q9HVZ9 (MURD_PSEAE): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MURD
Protein name
RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase;
EC 6.3.2.9;
AltName: Full=D-glutamic acid-adding enzyme;
AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase;
Gene name
murD

Comments [?]

Function Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Catalytic activity RHEA:16429: ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
EC 6.3.2.9
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
Subcellular location Cytoplasm.
Similarity Belongs to the MurCDEF family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0008764; Molecular function: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01225; Mur_ligase; 1;
PF02875; Mur_ligase_C; 1;
TIGRFAMs TIGR01087; MurD; 1;

Features [?]

From: MURD_ECOLI (P14900)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     112     118       ATP     G-[STA]-x-[GA]-K-[GST]-[ST]  

Additional information [?]

Size range 380-660 amino acids
Related rules MF_02208 (MURD2 supersedes the current rule)
Fusion None
Comments Also matches MurD2 subfamily (MF_02208). Insertion in POLSJ (not shown in alignment and not used in size range)