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Annotation rule MF_00641
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General rule information [?]

Accession MF_00641
Dates 26-APR-2003 (Created)
18-NOV-2019 (Last updated, Version 26)
Name Malate_synth_G
Templates P42450 (MASZ_CORGL); P37330 (MASZ_ECOLI); P9WK17 (MASZ_MYCTU): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Malate synthase G;
Gene name

Comments [?]

Function Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
Catalytic activity RHEA:18181: acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)
Cofactor Mg(2+)
Pathway Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.
Subunit Monomer.
Subcellular location Cytoplasm.
Similarity Belongs to the malate synthase family. GlcB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004474; Molecular function: malate synthase activity.
GO:0006097; Biological process: glyoxylate cycle.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01274; Malate_synthase; 1;
TIGRFAMs TIGR01345; Malate_syn_G; 1;

Features [?]

From: MASZ_ECOLI (P37330)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     125     126       Acetyl-CoA binding        
REGION     452     455       Glyoxylate binding        
ACT_SITE     338     338       Proton acceptor     R  
ACT_SITE     631     631       Proton donor     D  
METAL     427     427       Magnesium     E  
METAL     455     455       Magnesium     D  
BINDING     118     118       Acetyl-CoA; via carbonyl oxygen     V  
BINDING     274     274       Acetyl-CoA     S  
BINDING     311     311       Acetyl-CoA     R  
BINDING     338     338       Glyoxylate     R  
BINDING     427     427       Glyoxylate     E  
BINDING     536     536       Acetyl-CoA; via carbonyl oxygen     P  
MOD_RES     617     617       Cysteine sulfenic acid (-SOH)     C  
MOD_RES     688     688       Cysteine sulfenic acid (-SOH)     C  

Additional information [?]

Size range 721-748 amino acids
Related rules None
Fusion None