HAMAP rule MF_00646
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00646 |
| Accession | MF_00646 |
| Dates | 28-FEB-2005 (Created)
25-JUL-2025 (Last updated, Version 14) |
| Name | EFPL |
| Scope(s) |
Bacteria |
| Template(s) | P0A6N8; [ Recover all ] |
| Triggered by |
HAMAP; MF_00646 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | EFPL |
| Protein name | RecName: Full=Elongation factor protein EfpL; |
| Gene name | Name=efpL; |
Comments
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| FUNCTION | Involved in peptide bond synthesis. Alleviates ribosome stalling at di-proline-containing sequences; in rare cases stalled nascent peptides lacking di-Pro can also be rescued. |
| PATHWAY | Protein biosynthesis; polypeptide chain elongation. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| case <OC:Enterobacteriaceae> and <FTTag:acetyl> | |
| PTM | Acetylation of #{Lys-51} inactivates rescue of stalled ribosomes. |
| end case | |
| SIMILARITY | Belongs to the elongation factor P family. EfpL subfamily. |
Keywords
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| Cytoplasm | |
| Protein biosynthesis | |
| Elongation factor | |
| tRNA-binding | |
| RNA-binding | |
| case <OC:Enterobacteriaceae> and <FTTag:acetyl> | |
| Acetylation | |
| end case | |
Gene Ontology
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| GO:0072344; Biological process:rescue of stalled ribosome |
| GO:0003746; Molecular function:translation elongation factor activity |
| GO:0006414; Biological process:translational elongation |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01132; EFP; 1; |
| Pfam | PF08207; EFP_N; 1; |
| Pfam | PF09285; Elong-fact-P_C; 1; |
| NCBIfam | NF001810; PRK00529.1; 0-1; |
| NCBIfam | NF003392; PRK04542.1; 1; |
| NCBIfam | TIGR02178; yeiP; 0-1; |
| PROSITE | PS01275; EFP; 1; |
Features
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| From: EFPL_ECOLI (P0A6N8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| SITE | 33 | 33 | /note="Probably interacts with 3' end of the P-site tRNA" | R | ||||||||
| case <OC:Enterobacteriaceae> | ||||||||||||
| MOD_RES | 51 | 51 | /note="N6-acetyllysine" | acetyl | K | |||||||
| end case | ||||||||||||
Additional information
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| Size range | 170-210 amino acids |
| Related rules |
MF_00141 |
| Fusion | Nter: None Cter: None |