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HAMAP rule MF_00649

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General rule information [?]

Accession MF_00649
Dates 4-JUN-2003 (Created)
26-JAN-2023 (Last updated, Version 28)
Name DNA_gyrase_inhibitor_YacG
Bacteria; Pseudomonadota
Bacteria; Planctomycetota
Template P0A8H8 (YACG_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DNA gyrase inhibitor YacG;
Gene name

Comments [?]

Function Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion.
end case
Subunit Interacts with GyrB.
Similarity Belongs to the DNA gyrase inhibitor YacG family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0008657; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF03884; DUF329; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
BINDING     9     9       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     12     12       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     28     28       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     32     32       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1

Additional information [?]

Size range 48-82 amino acids
Related rules None
Fusion None