HAMAP rule MF_00649
General rule information
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| Accession | MF_00649 |
| Dates | 4-JUN-2003 (Created)
26-JAN-2023 (Last updated, Version 28) |
| Name | DNA_gyrase_inhibitor_YacG |
| Scope(s) |
Bacteria Pseudomonadota Planctomycetota |
| Template(s) | P0A8H8 (YACG_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_00649 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | YACG |
| Protein name | RecName: Full=DNA gyrase inhibitor YacG; |
| Gene name | Name=yacG; |
Comments
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| FUNCTION | Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion.; |
| end case | |
| SUBUNIT | Interacts with GyrB. |
| SIMILARITY | Belongs to the DNA gyrase inhibitor YacG family. |
Keywords
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| case <FTGroup:1> | |
| Zinc | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0008657; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
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| Pfam | PF03884; DUF329; 1; |
Features
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| From: YACG_ECOLI (P0A8H8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 9 | 9 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 12 | 12 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 28 | 28 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 32 | 32 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 48-82 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |