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HAMAP rule MF_00649

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General rule information [?]

Accession MF_00649
Dates 4-JUN-2003 (Created)
26-JAN-2023 (Last updated, Version 28)
Name DNA_gyrase_inhibitor_YacG
Scope(s) Bacteria
Template(s) P0A8H8 (YACG_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00649 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier YACG
Protein name RecName: Full=DNA gyrase inhibitor YacG;
Gene name Name=yacG;

Comments [?]

FUNCTIONInhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion.;
end case
SUBUNITInteracts with GyrB.
SIMILARITYBelongs to the DNA gyrase inhibitor YacG family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0008657; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Pfam PF03884; DUF329; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 9 9 /ligand="Zn(2+)"
C 1
BINDING 12 12 /ligand="Zn(2+)"
C 1
BINDING 28 28 /ligand="Zn(2+)"
C 1
BINDING 32 32 /ligand="Zn(2+)"
C 1

Additional information [?]

Size range 48-82 amino acids
Related rules None
Fusion Nter: None Cter: None

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