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Annotation rule MF_00649
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General rule information [?]

Accession MF_00649
Dates 4-JUN-2003 (Created)
18-NOV-2019 (Last updated, Version 24)
Name DNA_gyrase_inhibitor_YacG
Scope
Bacteria; Proteobacteria
Bacteria; Planctomycetes
Template P0A8H8 (YACG_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
YACG
Protein name
RecName: Full=DNA gyrase inhibitor YacG;
Gene name
yacG

Comments [?]

Function Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion.
end case
Subunit Interacts with GyrB.
Similarity Belongs to the DNA gyrase inhibitor YacG family.

Keywords [?]

case <FTGroup:1>
Zinc
Metal-binding
end case

Gene Ontology [?]

GO:0008657; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF03884; DUF329; 1;

Features [?]

From: YACG_ECOLI (P0A8H8)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     9     9       Zinc     C   1
METAL     12     12       Zinc     C   1
METAL     28     28       Zinc     C   1
METAL     32     32       Zinc     C   1

Additional information [?]

Size range 48-82 amino acids
Related rules None
Fusion None


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