HAMAP logo

HAMAP rule MF_00658

Send feedback

General rule information [?]

Accession MF_00658
Dates 17-JUN-2003 (Created)
1-JUN-2023 (Last updated, Version 35)
Name 23SrRNA_methyltr_H
Scope
Bacteria
Archaea; Euryarchaeota
Templates P0A8I8 (RLMH_ECOLI); P0C1V0 (RLMH_STAAU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RLMH
case <OC:Bacteria>
Protein name
RecName: Full=Ribosomal RNA large subunit methyltransferase H;
EC 2.1.1.177;
AltName: Full=23S rRNA (pseudouridine1915-N3)-methyltransferase;
AltName: Full=23S rRNA m3Psi1915 methyltransferase;
AltName: Full=rRNA (pseudouridine-N3-)-methyltransferase RlmH;
else case <OC:Archaea>
Protein name
RecName: Full=Putative ribosomal RNA large subunit methyltransferase H;
EC 2.1.1.177;
AltName: Full=23S rRNA (pseudouridine1915-N3)-methyltransferase;
AltName: Full=rRNA (pseudouridine-N3-)-methyltransferase RlmH;
end case
Gene name
rlmH

Comments [?]

Function Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
Catalytic activity RHEA:42752: pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine
EC 2.1.1.177
case <OC:Bacteria>
Subunit Homodimer.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the RNA methyltransferase RlmH family.

Keywords [?]

Cytoplasm
Methyltransferase
rRNA processing
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0070038; Molecular function: rRNA (pseudouridine-N3-)-methyltransferase activity.
GO:0031167; Biological process: rRNA methylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF02590; SPOUT_MTase; 1;
PIRSF PIRSF004505; MT_bac; 1;
NCBIfam TIGR00246; tRNA_RlmH_YbeA; 1;

Features [?]

From: RLMH_ECOLI (P0A8I8)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     122     127       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [LIVFM]-[GAST]-x-[LIM]-x-[LMFYW]  
BINDING (Optional)     72     72       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [LI]  
BINDING (Optional)     103     103       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [GA]  

Additional information [?]

Size range 120-210 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)