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HAMAP rule MF_00658

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General rule information [?]

Accession MF_00658
Dates 17-JUN-2003 (Created)
1-JUN-2023 (Last updated, Version 35)
Name 23SrRNA_methyltr_H
Scope(s) Bacteria
Archaea
Euryarchaeota
Template(s) P0A8I8 (RLMH_ECOLI); P0C1V0 (RLMH_STAAU); [ Recover all ]
Triggered by HAMAP; MF_00658 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RLMH
case <OC:Bacteria>
Protein name RecName: Full=Ribosomal RNA large subunit methyltransferase H;
                 EC=2.1.1.177;
AltName: Full=23S rRNA (pseudouridine1915-N3)-methyltransferase;
AltName: Full=23S rRNA m3Psi1915 methyltransferase;
AltName: Full=rRNA (pseudouridine-N3-)-methyltransferase RlmH;
else case <OC:Archaea>
Protein name RecName: Full=Putative ribosomal RNA large subunit methyltransferase H;
                 EC=2.1.1.177;
AltName: Full=23S rRNA (pseudouridine1915-N3)-methyltransferase;
AltName: Full=rRNA (pseudouridine-N3-)-methyltransferase RlmH;
end case
Gene name Name=rlmH;

Comments [?]

FUNCTIONSpecifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
CATALYTIC ACTIVITY Reaction=pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:42752, Rhea:RHEA-COMP:10221, Rhea:RHEA- COMP:10222, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65314, ChEBI:CHEBI:74486; EC=2.1.1.177;
case <OC:Bacteria>
SUBUNITHomodimer.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the RNA methyltransferase RlmH family.

Keywords [?]


Gene Ontology [?]

GO:0070038; Molecular function:rRNA (pseudouridine-N3-)-methyltransferase activity
GO:0031167; Biological process:rRNA methylation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF02590; SPOUT_MTase; 1;
PIRSF PIRSF004505; MT_bac; 1;
NCBIfam TIGR00246; tRNA_RlmH_YbeA; 1;

Features [?]

From: RLMH_ECOLI (P0A8I8)
Key From To Description Tag Condition FTGroup
BINDING 122 127 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[LIVFM]-[GAST]-x-[LIM]-x-[LMFYW]
BINDING 72 72 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[LI]
BINDING 103 103 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[GA]

Additional information [?]

Size range 120-210 amino acids
Related rules None
Fusion Nter: None Cter: None



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