HAMAP rule MF_00660
General rule information
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Accession | MF_00660 |
Dates | 20-JUN-2003 (Created) 19-NOV-2022 (Last updated, Version 33) |
Name | PqqE |
Scope | Bacteria |
Templates | P71517 (PQQE_METEA); P27507 (PQQE_KLEPN): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). |
Catalytic activity | RHEA:56836: [PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine
EC 1.21.98.4 |
case <FTGroup:1>
Cofactor | [4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. |
end case
Pathway | Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. |
Subunit | Interacts with PqqD. The interaction is necessary for activity of PqqE. |
Similarity | Belongs to the radical SAM superfamily. PqqE family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0009975; Molecular function: cyclase activity.
GO:1904047; Molecular function: S-adenosyl-L-methionine binding.
GO:1904047; Molecular function: S-adenosyl-L-methionine binding.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0018189; Biological process: pyrroloquinoline quinone biosynthetic process.
Cross-references
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Pfam | PF04055; Radical_SAM; 1; |
PIRSF | PIRSF037420; PQQ_syn_pqqE; 1; |
TIGRFAMs | TIGR02109; PQQ_syn_pqqE; 1; |
PROSITE | PS01305; MOAA_NIFB_PQQE; 1; |
PS51918; RADICAL_SAM; 1; trigger=PRU01266; |
Features
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From: PQQE_ACICA (P07782) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 19 | 19 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet | C | 1 | |||||||
BINDING | 23 | 23 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet | C | 1 | |||||||
BINDING | 26 | 26 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet | C | 1 |
Additional information
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Size range | 358-399 amino acids |
Related rules | None |
Fusion | None |