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HAMAP rule MF_00660

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General rule information [?]

Accession MF_00660
Dates 20-JUN-2003 (Created)
1-JUN-2023 (Last updated, Version 34)
Name PqqE
Scope(s) Bacteria
Template(s) P71517 (PQQE_METEA); P27507 (PQQE_KLEPN); [ Recover all ]
Triggered by HAMAP; MF_00660 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PQQE
Protein name RecName: Full=PqqA peptide cyclase;
AltName: Full=Coenzyme PQQ synthesis protein E;
Gene name Name=pqqE;

Comments [?]

FUNCTIONCatalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
CATALYTIC ACTIVITY Reaction=[PQQ precursor protein] + S-adenosyl-L-methionine = 5'- deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L- methionine; Xref=Rhea:RHEA:56836, Rhea:RHEA-COMP:14800, Rhea:RHEA- COMP:14801, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:141026, ChEBI:CHEBI:141027; EC=;
case <FTGroup:1>
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.;
end case
PATHWAYCofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
SUBUNITInteracts with PqqD. The interaction is necessary for activity of PqqE.
SIMILARITYBelongs to the radical SAM superfamily. PqqE family.

Keywords [?]

Gene Ontology [?]

GO:0009975; Molecular function:cyclase activity
GO:1904047; Molecular function:S-adenosyl-L-methionine binding
case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
end case
GO:0018189; Biological process:pyrroloquinoline quinone biosynthetic process

Cross-references [?]

Pfam PF04055; Radical_SAM; 1;
PIRSF PIRSF037420; PQQ_syn_pqqE; 1;
NCBIfam TIGR02109; PQQ_syn_pqqE; 1;

Features [?]

From: PQQE_ACICA (P07782)
Key From To Description Tag Condition FTGroup
BINDING 19 19 /ligand="[4Fe-4S] cluster"
C 1
BINDING 23 23 /ligand="[4Fe-4S] cluster"
C 1
BINDING 26 26 /ligand="[4Fe-4S] cluster"
C 1

Additional information [?]

Size range 358-399 amino acids
Related rules None
Fusion Nter: None Cter: None

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