HAMAP rule MF_00660
General rule information
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| Accession | MF_00660 |
| Dates | 20-JUN-2003 (Created)
2-SEP-2024 (Last updated, Version 35) |
| Name | PqqE |
| Scope(s) |
Bacteria |
| Template(s) | P71517 (PQQE_METEA); P27507 (PQQE_KLEPN); [ Recover all ] |
| Triggered by |
HAMAP; MF_00660 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PQQE |
| Protein name | RecName: Full=PqqA peptide cyclase; EC=1.21.98.4; AltName: Full=Coenzyme PQQ synthesis protein E; |
| Gene name | Name=pqqE; |
Comments
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| FUNCTION | Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). |
| CATALYTIC ACTIVITY | Reaction=[PQQ precursor protein] + S-adenosyl-L-methionine = E-Y cross- linked-[PQQ precursor protein] + 5'-deoxyadenosine + L-methionine + H(+); Xref=Rhea:RHEA:56836, Rhea:RHEA-COMP:14800, Rhea:RHEA- COMP:14801, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:141026, ChEBI:CHEBI:141027; EC=1.21.98.4; |
| case <FTGroup:1> | |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.; |
| end case | |
| PATHWAY | Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. |
| SUBUNIT | Interacts with PqqD. The interaction is necessary for activity of PqqE. |
| SIMILARITY | Belongs to the radical SAM superfamily. PqqE family. |
Keywords
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| Oxidoreductase | |
| PQQ biosynthesis | |
| case <FTGroup:1> | |
| 4Fe-4S | |
| Metal-binding | |
| Iron | |
| Iron-sulfur | |
| S-adenosyl-L-methionine | |
| end case | |
Gene Ontology
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| GO:0009975; Molecular function:cyclase activity | |
| GO:1904047; Molecular function:S-adenosyl-L-methionine binding | |
| case <FTGroup:1> | |
| GO:0005506; Molecular function:iron ion binding | |
| end case | |
| GO:0018189; Biological process:pyrroloquinoline quinone biosynthetic process | |
Cross-references
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| Pfam | PF04055; Radical_SAM; 1; |
| PIRSF | PIRSF037420; PQQ_syn_pqqE; 1; |
| NCBIfam | TIGR02109; PQQ_syn_pqqE; 1; |
| PROSITE | PS01305; MOAA_NIFB_PQQE; 1; |
| PROSITE | PS51918; RADICAL_SAM; 1; |
Features
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| From: PQQE_ACICA (P07782) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 19 | 19 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
| BINDING | 23 | 23 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
| BINDING | 26 | 26 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
Additional information
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| Size range | 358-399 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |