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HAMAP rule MF_00660

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General rule information [?]

Accession MF_00660
Dates 20-JUN-2003 (Created)
19-NOV-2022 (Last updated, Version 33)
Name PqqE
Templates P71517 (PQQE_METEA); P27507 (PQQE_KLEPN): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=PqqA peptide cyclase;
AltName: Full=Coenzyme PQQ synthesis protein E;
Gene name

Comments [?]

Function Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
Catalytic activity RHEA:56836: [PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine
case <FTGroup:1>
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
end case
Pathway Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
Subunit Interacts with PqqD. The interaction is necessary for activity of PqqE.
Similarity Belongs to the radical SAM superfamily. PqqE family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0009975; Molecular function: cyclase activity.
GO:1904047; Molecular function: S-adenosyl-L-methionine binding.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0018189; Biological process: pyrroloquinoline quinone biosynthetic process.

Cross-references [?]

Pfam PF04055; Radical_SAM; 1;
PIRSF PIRSF037420; PQQ_syn_pqqE; 1;
TIGRFAMs TIGR02109; PQQ_syn_pqqE; 1;
PS51918; RADICAL_SAM; 1; trigger=PRU01266;

Features [?]

From: PQQE_ACICA (P07782)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     19     19       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet     C   1
BINDING     23     23       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet     C   1
BINDING     26     26       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet     C   1

Additional information [?]

Size range 358-399 amino acids
Related rules None
Fusion None