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Annotation rule MF_00660 |
General rule information
[?]
Accession |
MF_00660 |
Dates |
20-JUN-2003 (Created) 3-APR-2020 (Last updated, Version 31) |
Propagated annotation
[?]
Identifier, protein and gene names
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Protein name |
RecName:
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Full=PqqA peptide cyclase;
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EC 1.21.98.4;
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AltName:
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Full=Coenzyme PQQ synthesis protein E;
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Function |
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). |
Catalytic activity |
RHEA:56836: [PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine
EC 1.21.98.4
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case <FTGroup:1>
Cofactor |
[4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. |
end case
Pathway |
Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. |
Subunit |
Interacts with PqqD. The interaction is necessary for activity of PqqE. |
Similarity |
Belongs to the radical SAM superfamily. PqqE family. |
case <FTGroup:1>
end case
GO:0009975; Molecular function: cyclase activity.
GO:1904047; Molecular function: S-adenosyl-L-methionine binding.
case <FTGroup:1>
end case
GO:0018189; Biological process: pyrroloquinoline quinone biosynthetic process.
From: PQQE_ACICA (P07782) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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METAL
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19
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19
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Iron-sulfur (4Fe-4S-S-AdoMet)
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C
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1
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METAL
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23
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23
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Iron-sulfur (4Fe-4S-S-AdoMet)
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C
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1
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METAL
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26
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26
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Iron-sulfur (4Fe-4S-S-AdoMet)
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C
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1
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Additional information
[?]
Size range |
358-399 amino acids |
Related rules |
None |
Fusion |
None |