HAMAP rule MF_00660

General rule information [?]

Accession	MF_00660
Dates	20-JUN-2003 (Created) 19-NOV-2022 (Last updated, Version 33)

Name

PqqE

Scope

Bacteria

Templates

P71517 (PQQE_METEA); P27507 (PQQE_KLEPN): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PQQE

Protein name

RecName:		Full=PqqA peptide cyclase;
		EC 1.21.98.4;
AltName:		Full=Coenzyme PQQ synthesis protein E;

Gene name

pqqE

Comments [?]

Function	Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
Catalytic activity	RHEA:56836: [PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine EC 1.21.98.4

case <FTGroup:1>

Cofactor

[4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

end case

Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
Subunit	Interacts with PqqD. The interaction is necessary for activity of PqqE.
Similarity	Belongs to the radical SAM superfamily. PqqE family.

Keywords [?]

case <FTGroup:1>

end case

Gene Ontology [?]

GO:0009975; Molecular function: cyclase activity.
GO:1904047; Molecular function: S-adenosyl-L-methionine binding.

case <FTGroup:1>

GO:0005506; Molecular function: iron ion binding.

end case

GO:0018189; Biological process: pyrroloquinoline quinone biosynthetic process.

Cross-references [?]

Features [?]

From: PQQE_ACICA (P07782)

Key From To Description Tag Condition FTGroup

BINDING 19 19 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet C 1

BINDING 23 23 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet C 1

BINDING 26 26 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet C 1

Additional information [?]