HAMAP rule MF_00673
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_00673 |
| Accession | MF_00673 |
| Dates | 28-FEB-2005 (Created)
27-AUG-2025 (Last updated, Version 13) |
| Name | HcgF |
| Scope(s) |
Archaea |
| Template(s) | None |
| Triggered by |
HAMAP; MF_00673 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HCGF |
| Protein name | RecName: Full=Iron-guanylylpyridinol cofactor biosynthesis protein HcgF; EC=2.3.1.-; |
| Gene name | Name=hcgF; |
Comments
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| FUNCTION | Product of one of the 7 hmd co-occurring genes (hcg), hcgA-G, which cluster with the [Fe]-hydrogenase-encoding gene hmd and are required for the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor used by [Fe]-hydrogenase. HcgF catalyzes the transesterification of guanylylpyridinol-AMP produced by HcgE to afford a Cys(HcgF)-S-guanylylpyridinol thioester. |
| CATALYTIC ACTIVITY | Reaction=guanylylpyridinol-AMP + L-cysteinyl-[protein] = S- guanylylpyridinol-L-cysteinyl-[protein] + AMP + H(+); Xref=Rhea:RHEA:85899, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:20679, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:234400, ChEBI:CHEBI:235321, ChEBI:CHEBI:456215; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:85900; Evidence=; |
| PATHWAY | Cofactor biosynthesis. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the HcgF family. |
Keywords
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Gene Ontology
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| GO:0016746; Molecular function:acyltransferase activity |
Cross-references
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| Pfam | PF06787; HcgF; 1; |
| NCBIfam | NF002122; PRK00962.1; 1; |
| PIRSF | PIRSF018786; UPF0254; 1; |
Features
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| From: HCGF_METJA (Q58649) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 9 | 9 | /note="Nucleophile" | C | ||||||||
| BINDING | 9 | 9 | /ligand="guanylylpyridinol" /ligand_id="ChEBI:CHEBI:234382" /note="covalent" |
C | ||||||||
| BINDING | 10 | 10 | /ligand="guanylylpyridinol" /ligand_id="ChEBI:CHEBI:234382" |
F | ||||||||
| BINDING | 12 | 12 | /ligand="guanylylpyridinol" /ligand_id="ChEBI:CHEBI:234382" |
H | ||||||||
| BINDING | 20 | 20 | /ligand="guanylylpyridinol" /ligand_id="ChEBI:CHEBI:234382" |
H | ||||||||
| BINDING | 26 | 26 | /ligand="guanylylpyridinol" /ligand_id="ChEBI:CHEBI:234382" |
Y | ||||||||
| BINDING | 27 | 27 | /ligand="guanylylpyridinol" /ligand_id="ChEBI:CHEBI:234382" |
E | ||||||||
| BINDING | 110 | 110 | /ligand="guanylylpyridinol" /ligand_id="ChEBI:CHEBI:234382" |
T | ||||||||
| BINDING | 111 | 111 | /ligand="guanylylpyridinol" /ligand_id="ChEBI:CHEBI:234382" |
A | ||||||||
| BINDING | 146 | 146 | /ligand="guanylylpyridinol" /ligand_id="ChEBI:CHEBI:234382" |
R | ||||||||
Additional information
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| Size range | 157-182 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |