HAMAP rule MF_00687

General rule information [?]

Accession	MF_00687
Dates	23-JUL-2003 (Created) 19-NOV-2022 (Last updated, Version 26)

Name

KduI

Scope

Bacteria

Templates

Q46938 (KDUI_ECOLI); Q05529 (KDUI_DICD3); P50843 (KDUI_BACSU): [Recover all]

Triggered by

HAMAP; MF_00687 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

KDUI

Protein name

RecName:		Full=4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase;
		EC 5.3.1.17;
AltName:		Full=5-keto-4-deoxyuronate isomerase;
AltName:		Full=DKI isomerase;

Gene name

kduI

Comments [?]

Function	Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
Catalytic activity	RHEA:23896: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate EC 5.3.1.17

case <FTGroup:1>

Cofactor

Zn(2+)
Note: Binds 1 zinc ion per subunit.

end case

Pathway

Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5.

case <OC:Escherichia>

Subunit

Homohexamer.

end case

Similarity

Belongs to the KduI family.

Keywords [?]

Isomerase

case <FTGroup:1>

Metal-binding
Zinc

end case

Gene Ontology [?]

case <FTGroup:1>

GO:0008270; Molecular function: zinc ion binding.

end case

GO:0008697; Molecular function: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity.
GO:0045490; Biological process: pectin catabolic process.

Cross-references [?]

Pfam	PF04962; KduI; 1;

Features [?]

From: KDUI_ECOLI (Q46938)

Key From To Description Tag Condition FTGroup

BINDING 196 196 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING 198 198 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING 203 203 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 E 1

BINDING 245 245 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

Additional information [?]

Size range	274-292 amino acids
Related rules	None
Fusion	None

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