HAMAP rule MF_00687
General rule information
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| Accession | MF_00687 |
| Dates | 23-JUL-2003 (Created)
19-NOV-2022 (Last updated, Version 26) |
| Name | KduI |
| Scope(s) |
Bacteria |
| Template(s) | Q46938 (KDUI_ECOLI); Q05529 (KDUI_DICD3); P50843 (KDUI_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00687 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KDUI |
| Protein name | RecName: Full=4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; EC=5.3.1.17; AltName: Full=5-keto-4-deoxyuronate isomerase; AltName: Full=DKI isomerase; |
| Gene name | Name=kduI; |
Comments
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| FUNCTION | Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. |
| CATALYTIC ACTIVITY | Reaction=5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5- hexodiulosonate; Xref=Rhea:RHEA:23896, ChEBI:CHEBI:17117, ChEBI:CHEBI:29071; EC=5.3.1.17; |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| PATHWAY | Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D- gluconate from pectin: step 4/5. |
| case <OC:Escherichia> | |
| SUBUNIT | Homohexamer. |
| end case | |
| SIMILARITY | Belongs to the KduI family. |
Keywords
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| Isomerase | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0008697; Molecular function:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity | |
| GO:0045490; Biological process:pectin catabolic process | |
Cross-references
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| Pfam | PF04962; KduI; 1; |
Features
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| From: KDUI_ECOLI (Q46938) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 196 | 196 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 198 | 198 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 203 | 203 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
E | 1 | |||||||
| BINDING | 245 | 245 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
Additional information
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| Size range | 274-292 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |