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HAMAP rule MF_00688

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General rule information [?]

Accession MF_00688
Dates 24-JUL-2003 (Created)
28-JUL-2023 (Last updated, Version 25)
Name Leu_Phe_trans
Scope(s) Bacteria
Template(s) P0A8P1 (LFTR_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00688 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LFTR
Protein name RecName: Full=Leucyl/phenylalanyl-tRNA--protein transferase;
AltName: Full=L/F-transferase;
AltName: Full=Leucyltransferase;
AltName: Full=Phenyalanyltransferase;
Gene name Name=aat;

Comments [?]

FUNCTIONFunctions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
CATALYTIC ACTIVITY Reaction=L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N- terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu); Xref=Rhea:RHEA:12340, Rhea:RHEA-COMP:9613, Rhea:RHEA-COMP:9622, Rhea:RHEA-COMP:12670, Rhea:RHEA-COMP:12671, ChEBI:CHEBI:15378, ChEBI:CHEBI:65249, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:133043; EC=;
CATALYTIC ACTIVITY Reaction=L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu); Xref=Rhea:RHEA:50416, Rhea:RHEA-COMP:9613, Rhea:RHEA-COMP:9622, Rhea:RHEA-COMP:12672, Rhea:RHEA-COMP:12673, ChEBI:CHEBI:15378, ChEBI:CHEBI:64719, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:133044; EC=;
CATALYTIC ACTIVITY Reaction=an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl- tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe); Xref=Rhea:RHEA:43632, Rhea:RHEA-COMP:9668, Rhea:RHEA- COMP:9699, Rhea:RHEA-COMP:10636, Rhea:RHEA-COMP:10637, ChEBI:CHEBI:78442, ChEBI:CHEBI:78531, ChEBI:CHEBI:78597, ChEBI:CHEBI:83561; EC=;
SIMILARITYBelongs to the L/F-transferase family.

Keywords [?]

Gene Ontology [?]

GO:0008914; Molecular function:leucyl-tRNA--protein transferase activity
GO:0030163; Biological process:protein catabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF03588; Leu_Phe_trans; 1;
NCBIfam TIGR00667; Aat; 1;

Features [?]

Additional information [?]

Size range 191-274 amino acids
Related rules None
Fusion Nter: None Cter: None

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