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Annotation rule MF_00688
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General rule information [?]

Accession MF_00688
Dates 24-JUL-2003 (Created)
18-NOV-2019 (Last updated, Version 23)
Name Leu_Phe_trans
Scope
Bacteria
Template P0A8P1 (LFTR_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LFTR
Protein name
RecName: Full=Leucyl/phenylalanyl-tRNA--protein transferase;
EC 2.3.2.6;
AltName: Full=L/F-transferase;
AltName: Full=Leucyltransferase;
AltName: Full=Phenyalanyltransferase;
Gene name
aat

Comments [?]

Function Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
Catalytic activity RHEA:12340: L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)
EC 2.3.2.6
RHEA:50416: L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)
EC 2.3.2.6
RHEA:43632: an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)
EC 2.3.2.6
Subcellular location Cytoplasm.
Similarity Belongs to the L/F-transferase family.

Keywords [?]


Gene Ontology [?]

GO:0008914; Molecular function: leucyltransferase activity.
GO:0030163; Biological process: protein catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF03588; Leu_Phe_trans; 1;
TIGRFAMs TIGR00667; Aat; 1;

Additional information [?]

Size range 191-274 amino acids
Related rules None
Fusion None