Home  |  Contact
Annotation rule MF_00700
Send feedback

General rule information [?]

Accession MF_00700
Dates 26-AUG-2003 (Created)
18-NOV-2019 (Last updated, Version 19)
Name DNA_primase_sml_arc
Templates O57934 (PRIS_PYRHO); Q9P9H1 (PRIS_PYRFU); Q97Z83 (PRIS_SACS2); Q5JJ72 (PRIS_THEKO); Q58249 (PRIS_METJA); Q9V292 (PRIS_PYRAB): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DNA primase small subunit PriS;
EC 2.7.7.-;
Gene name

Comments [?]

Function Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Cofactor Mg(2+)
Subunit Heterodimer of a small subunit (PriS) and a large subunit (PriL).
Similarity Belongs to the eukaryotic-type primase small subunit family.

Keywords [?]

Gene Ontology [?]

GO:0003896; Molecular function: DNA primase activity.
GO:0006269; Biological process: DNA replication, synthesis of RNA primer.

Cross-references [?]

Pfam PF01896; DNA_primase_S; 1;
TIGRFAMs TIGR00335; Primase_sml; 1;

Features [?]

From: PRIS_PYRHO (O57934)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     95     95             D  
ACT_SITE     97     97             D  
ACT_SITE     280     280             D  

Additional information [?]

Size range 296-442 amino acids
Related rules None
Fusion None