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HAMAP rule MF_00700

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General rule information [?]

Accession MF_00700
Dates 26-AUG-2003 (Created)
1-JUN-2023 (Last updated, Version 20)
Name DNA_primase_sml_arc
Scope(s) Archaea
Template(s) O57934 (PRIS_PYRHO); Q9P9H1 (PRIS_PYRFU); Q97Z83 (PRIS_SACS2); Q5JJ72 (PRIS_THEKO); Q58249 (PRIS_METJA); Q9V292 (PRIS_PYRAB); [ Recover all ]
Triggered by HAMAP; MF_00700 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PRIS
Protein name RecName: Full=DNA primase small subunit PriS;
Gene name Name=priS;

Comments [?]

FUNCTIONCatalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
SUBUNITHeterodimer of a small subunit (PriS) and a large subunit (PriL).
SIMILARITYBelongs to the eukaryotic-type primase small subunit family.

Keywords [?]

Gene Ontology [?]

GO:0003896; Molecular function:DNA primase activity
GO:0006269; Biological process:DNA replication, synthesis of RNA primer

Cross-references [?]

Pfam PF01896; DNA_primase_S; 1;
NCBIfam TIGR00335; Primase_sml; 1;

Features [?]

From: PRIS_PYRHO (O57934)
Key From To Description Tag Condition FTGroup
ACT_SITE 95 95 D
ACT_SITE 97 97 D
ACT_SITE 280 280 D

Additional information [?]

Size range 296-442 amino acids
Related rules None
Fusion Nter: None Cter: None

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