HAMAP rule MF_00700
General rule information
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| Accession | MF_00700 |
| Dates | 26-AUG-2003 (Created)
25-APR-2024 (Last updated, Version 21) |
| Name | DNA_primase_sml_arc |
| Scope(s) |
Archaea |
| Template(s) | O57934 (PRIS_PYRHO); Q9P9H1 (PRIS_PYRFU); Q97Z83 (PRIS_SACS2); Q5JJ72 (PRIS_THEKO); Q58249 (PRIS_METJA); Q9V292 (PRIS_PYRAB); [ Recover all ] |
| Triggered by |
HAMAP; MF_00700 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PRIS |
| Protein name | RecName: Full=DNA primase small subunit PriS; EC=2.7.7.-; |
| Gene name | Name=priS; |
Comments
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| FUNCTION | Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| SUBUNIT | Heterodimer of a small subunit (PriS) and a large subunit (PriL). |
| SIMILARITY | Belongs to the eukaryotic-type primase small subunit family. |
Keywords
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| DNA replication |
| DNA-directed RNA polymerase |
| Magnesium |
| Manganese |
| Metal-binding |
| Nucleotidyltransferase |
| Primosome |
| Transcription |
| Transferase |
Gene Ontology
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| GO:0003896; Molecular function:DNA primase activity |
| GO:0006269; Biological process:DNA replication, synthesis of primer |
Cross-references
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Features
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| From: PRIS_PYRHO (O57934) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 95 | 95 | D | |||||||||
| ACT_SITE | 97 | 97 | D | |||||||||
| ACT_SITE | 280 | 280 | D | |||||||||
Additional information
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| Size range | 296-442 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |