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HAMAP rule MF_00701

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General rule information [?]

Accession MF_00701
Dates 28-AUG-2003 (Created)
19-NOV-2022 (Last updated, Version 21)
Name DNA_primase_lrg_arc
Scope
Archaea
Templates Q9UWW1 (PRIL_SACS2); Q8U4H7 (PRIL_PYRFU); O57935 (PRIL_PYRHO); Q5JJ73 (PRIL_THEKO); Q9V291 (PRIL_PYRAB): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PRIL
Protein name
RecName: Full=DNA primase large subunit PriL;
Gene name
priL

Comments [?]

Function Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
case <FTGroup:1>
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster.
end case
Subunit Heterodimer of a small subunit (PriS) and a large subunit (PriL).
Similarity Belongs to the eukaryotic-type primase large subunit family.

Keywords [?]

DNA replication
Primosome
case <FTGroup:1>
4Fe-4S
Iron
Iron-sulfur
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
end case
GO:0006269; Biological process: DNA replication, synthesis of RNA primer.

Cross-references [?]

Pfam PF04104; DNA_primase_lrg; 1;

Features [?]

From: PRIL_SACS2 (Q9UWW1)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     216     216       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING (Optional)     280     280       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING (Optional)     289     289       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING (Optional)     293     293       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1

Additional information [?]

Size range 295-500 amino acids
Related rules None
Fusion None


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