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HAMAP rule MF_00701

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General rule information [?]

Accession MF_00701
Dates 28-AUG-2003 (Created)
19-NOV-2022 (Last updated, Version 21)
Name DNA_primase_lrg_arc
Scope(s) Archaea
Template(s) Q9UWW1 (PRIL_SACS2); Q8U4H7 (PRIL_PYRFU); O57935 (PRIL_PYRHO); Q5JJ73 (PRIL_THEKO); Q9V291 (PRIL_PYRAB); [ Recover all ]
Triggered by HAMAP; MF_00701 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PRIL
Protein name RecName: Full=DNA primase large subunit PriL;
Gene name Name=priL;

Comments [?]

FUNCTIONRegulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
case <FTGroup:1>
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster.;
end case
SUBUNITHeterodimer of a small subunit (PriS) and a large subunit (PriL).
SIMILARITYBelongs to the eukaryotic-type primase large subunit family.

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding
end case
GO:0006269; Biological process:DNA replication, synthesis of RNA primer

Cross-references [?]

Pfam PF04104; DNA_primase_lrg; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 216 216 /ligand="[4Fe-4S] cluster"
C 1
BINDING 280 280 /ligand="[4Fe-4S] cluster"
C 1
BINDING 289 289 /ligand="[4Fe-4S] cluster"
C 1
BINDING 293 293 /ligand="[4Fe-4S] cluster"
C 1

Additional information [?]

Size range 295-500 amino acids
Related rules None
Fusion Nter: None Cter: None

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