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HAMAP rule MF_00705

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General rule information [?]

Accession MF_00705
Dates 1-SEP-2003 (Created)
1-JUN-2023 (Last updated, Version 24)
Name IMP_cyclohydrol
Scope(s) Archaea
Template(s) Q58043 (PURO_METJA); [ Recover all ]
Triggered by HAMAP; MF_00705 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PURO
RecName: Full=IMP cyclohydrolase;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/"></a>;<br /> AltName: Full=IMP synthase;<br /> AltName: Full=Inosinicase;
Gene name Name=purO;

Comments [?]

FUNCTIONCatalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP.
CATALYTIC ACTIVITY Reaction=H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide; Xref=Rhea:RHEA:18445, ChEBI:CHEBI:15377, ChEBI:CHEBI:58053, ChEBI:CHEBI:58467; EC=;
PATHWAYPurine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.
SIMILARITYBelongs to the archaeal IMP cyclohydrolase family.

Keywords [?]

Gene Ontology [?]

GO:0003937; Molecular function:IMP cyclohydrolase activity
GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

Pfam PF07826; IMP_cyclohyd; 1;
PIRSF PIRSF004866; IMP_cclhdr_arch; 1;
NCBIfam TIGR01922; PurO_arch; 1;

Features [?]

Additional information [?]

Size range 190-230 amino acids
Related rules None
Fusion Nter: None Cter: None

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