HAMAP rule MF_00705
General rule information
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Accession | MF_00705 |
Dates | 1-SEP-2003 (Created)
1-JUN-2023 (Last updated, Version 24) |
Name | IMP_cyclohydrol |
Scope(s) |
Archaea |
Template(s) | Q58043 (PURO_METJA); [ Recover all ] |
Triggered by |
HAMAP; MF_00705 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PURO |
RecName: Full=IMP cyclohydrolase;<br /> EC=<a href="https://enzyme.expasy.org/EC/3.5.4.10">3.5.4.10</a>;<br /> AltName: Full=IMP synthase;<br /> AltName: Full=Inosinicase; | |
Gene name | Name=purO; |
Comments
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FUNCTION | Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. |
CATALYTIC ACTIVITY | Reaction=H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide; Xref=Rhea:RHEA:18445, ChEBI:CHEBI:15377, ChEBI:CHEBI:58053, ChEBI:CHEBI:58467; EC=3.5.4.10; |
PATHWAY | Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. |
SIMILARITY | Belongs to the archaeal IMP cyclohydrolase family. |
Keywords
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Gene Ontology
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GO:0003937; Molecular function:IMP cyclohydrolase activity |
GO:0006189; Biological process:'de novo' IMP biosynthetic process |
Cross-references
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Pfam | PF07826; IMP_cyclohyd; 1; |
PIRSF | PIRSF004866; IMP_cclhdr_arch; 1; |
NCBIfam | TIGR01922; PurO_arch; 1; |
Features
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Additional information
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Size range | 190-230 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |